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The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.
Endocr Res. 2018 Feb; 43(1):1-10.ER

Abstract

PURPOSE OF THE STUDY

There was inconsistent evidence about the benefit of vitamin D plus evening primrose oil (EPO) supplement intake on lipid profiles and reduced oxidative stress among women with polycystic ovary syndrome (PCOS). The current study was performed to evaluate the effects of vitamin D plus EPO supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with PCOS.

MATERIALS AND METHODS

This randomized, double-blind, placebo-controlled trial was performed among 60 vitamin D-deficient women with PCOS. Participants were randomly assigned into two groups to receive either 1000 IU vitamin D3 plus 1000 mg EPO (n = 30) or placebo (n = 30) for 12 weeks. Metabolic profiles were quantified at baseline and after the 12-week intervention.

RESULTS

Compared with the placebo group, women in vitamin D and EPO co-supplementation group had significant increases in serum 25-hydroxyvitamin D (25(OH)D) (+10.7 ± 8.4 vs. -0.5 ± 1.6 ng/mL, p < 0.001) and plasma total glutathione (GSH) (+62.7 ± 58.0 vs. -0.7 ± 122.7 µmol/L, p = 0.01), while there were significant decreases in triglycerides (-7.3 ± 23.8 vs. +6.9 ± 26.3 mg/dL, p = 0.03), very low-density lipoprotein (VLDL) cholesterol levels (-1.5 ± 4.7 vs. +1.4 ± 5.3 mg/dL, p = 0.03), total/high-density lipoprotein cholesterol ratio (-0.3 ± 0.4 vs. -0.02 ± 0.4, p = 0.02), and malondialdehyde (MDA) concentration (-0.4 ± 0.4 vs. +0.5 ± 1.8 µmol/L, p = 0.008).

CONCLUSION

Overall, vitamin D and EPO co-supplementation for 12 weeks among vitamin D-deficient women with PCOS significantly improved triglycerides, VLDL cholesterol, GSH, and MDA levels.

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Publisher Full Text (DOI)

Authors+Show Affiliations

a Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics , School of Medicine, Arak University of Medical Sciences , Arak , Iran.

a Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics , School of Medicine, Arak University of Medical Sciences , Arak , Iran.

b Department of Gynecology and Obstetrics, School of Medicine , Iran University of Medical Sciences , Tehran , Iran.

c Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R . Iran.

c Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R . Iran.

Mazandaranian MR

c Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R . Iran.

c Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R . Iran.

d Barij Medicinal Plants Research Center , Kashan , I.R . Iran.

c Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R . Iran.

Pub Type(s)

Journal Article

Randomized Controlled Trial

Language

eng

PubMed ID

28742409

Citation

Nasri, Khadijeh, et al. "The Effects of Vitamin D and Evening Primrose Oil Co-supplementation On Lipid Profiles and Biomarkers of Oxidative Stress in Vitamin D-deficient Women With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial." Endocrine Research, vol. 43, no. 1, 2018, pp. 1-10.

Nasri K, Akrami S, Rahimi M, et al. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Endocr Res. 2018;43(1):1-10.

Nasri, K., Akrami, S., Rahimi, M., Taghizadeh, M., Behfar, M., Mazandaranian, M. R., Kheiry, A., Memarzadeh, M. R., & Asemi, Z. (2018). The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Endocrine Research, 43(1), 1-10. https://doi.org/10.1080/07435800.2017.1346661

Nasri K, et al. The Effects of Vitamin D and Evening Primrose Oil Co-supplementation On Lipid Profiles and Biomarkers of Oxidative Stress in Vitamin D-deficient Women With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial. Endocr Res. 2018;43(1):1-10. PubMed PMID: 28742409.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. AU - Nasri,Khadijeh, AU - Akrami,Sedighe, AU - Rahimi,Maryam, AU - Taghizadeh,Mohsen, AU - Behfar,Masoud, AU - Mazandaranian,Mohammad Reza, AU - Kheiry,Abbas, AU - Memarzadeh,Mohammad Reza, AU - Asemi,Zatollah, Y1 - 2017/07/25/ PY - 2017/7/26/pubmed PY - 2018/8/25/medline PY - 2017/7/26/entrez KW - Lipid profiles KW - oxidative stress KW - polycystic ovary syndrome KW - supplementation SP - 1 EP - 10 JF - Endocrine research JO - Endocr Res VL - 43 IS - 1 N2 - PURPOSE OF THE STUDY: There was inconsistent evidence about the benefit of vitamin D plus evening primrose oil (EPO) supplement intake on lipid profiles and reduced oxidative stress among women with polycystic ovary syndrome (PCOS). The current study was performed to evaluate the effects of vitamin D plus EPO supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with PCOS. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was performed among 60 vitamin D-deficient women with PCOS. Participants were randomly assigned into two groups to receive either 1000 IU vitamin D3 plus 1000 mg EPO (n = 30) or placebo (n = 30) for 12 weeks. Metabolic profiles were quantified at baseline and after the 12-week intervention. RESULTS: Compared with the placebo group, women in vitamin D and EPO co-supplementation group had significant increases in serum 25-hydroxyvitamin D (25(OH)D) (+10.7 ± 8.4 vs. -0.5 ± 1.6 ng/mL, p < 0.001) and plasma total glutathione (GSH) (+62.7 ± 58.0 vs. -0.7 ± 122.7 µmol/L, p = 0.01), while there were significant decreases in triglycerides (-7.3 ± 23.8 vs. +6.9 ± 26.3 mg/dL, p = 0.03), very low-density lipoprotein (VLDL) cholesterol levels (-1.5 ± 4.7 vs. +1.4 ± 5.3 mg/dL, p = 0.03), total/high-density lipoprotein cholesterol ratio (-0.3 ± 0.4 vs. -0.02 ± 0.4, p = 0.02), and malondialdehyde (MDA) concentration (-0.4 ± 0.4 vs. +0.5 ± 1.8 µmol/L, p = 0.008). CONCLUSION: Overall, vitamin D and EPO co-supplementation for 12 weeks among vitamin D-deficient women with PCOS significantly improved triglycerides, VLDL cholesterol, GSH, and MDA levels. SN - 1532-4206 UR - https://www.unboundmedicine.com/medline/citation/28742409/The_effects_of_vitamin_D_and_evening_primrose_oil_co_supplementation_on_lipid_profiles_and_biomarkers_of_oxidative_stress_in_vitamin_D_deficient_women_with_polycystic_ovary_syndrome:_A_randomized_double_blind_placebo_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -