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Reproductive factors and risk of Parkinson's disease in women: A meta-analysis of observational studies.
Behav Brain Res. 2017 09 29; 335:103-110.BB

Abstract

Evidence on the relationship between reproductive factors, use of oral contraceptives (OCs) and the incidence of Parkinson's disease (PD) remain inconclusive. The aim of this meta-analysis is to evaluate whether relevant reproductive factors including age at menarche, age at menopause, fertile lifespan, parity, type of menopause (surgical versus natural), and use of OCs are associated with risk of PD in women via random-effects model. PubMed and EMBASE database were used to search for case-control or cohort studies published before February17, 2017. 6 case-control and 5 cohort studies were included in the meta-analysis. The pooled relative risks (RRs) of PD risk were 1.00 (95% CI: 0.79-1.28) for use of OCs (ever versus never), 1.03 (95% CI: 0.84-1.26) for age at menarche, 0.98 (95% CI: 0.75-1.29) for age at menopause, 0.98(95% CI: 0.77-1.25) for fertile lifespan, 0.99(95% CI:0.0.79-1.25) for parity, 0.93 (95% CI:0.68-1.29) for type of menopause (surgical versus natural). In the subgroup analysis stratified by study design, age, caffeine intake and smoking, an inverse association was found between surgical menopause and risk of PD for those adjusting for caffeine intake (RR: 0.67, 95% CI: 0.45-0.99) and smoking (RR: 0.77, 95% CI: 0.63-0.94); while a positive association was found between surgical menopause and PD risk for those not adjusting for smoking (RR: 1.91, 95% CI: 1.29-2.83). In conclusion, our meta-analysis provided little epidemiological support for the role of reproductive factors in the incidence of PD. Whether surgical menopause is inversely associated with the risk of PD requires further explorations.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, PR China.Xiangchen District Center for Disease Control and Prevention, Suzhou, PR China.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, PR China.Department of Health Research Methods, Evidence, and Impact, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, PR China.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, PR China.Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, PR China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, 199 Ren'ai Road, Suzhou, 215123, PR China. Electronic address: zhxwan@suda.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

28743601

Citation

Lv, Menglian, et al. "Reproductive Factors and Risk of Parkinson's Disease in Women: a Meta-analysis of Observational Studies." Behavioural Brain Research, vol. 335, 2017, pp. 103-110.
Lv M, Zhang Y, Chen GC, et al. Reproductive factors and risk of Parkinson's disease in women: A meta-analysis of observational studies. Behav Brain Res. 2017;335:103-110.
Lv, M., Zhang, Y., Chen, G. C., Li, G., Rui, Y., Qin, L., & Wan, Z. (2017). Reproductive factors and risk of Parkinson's disease in women: A meta-analysis of observational studies. Behavioural Brain Research, 335, 103-110. https://doi.org/10.1016/j.bbr.2017.07.025
Lv M, et al. Reproductive Factors and Risk of Parkinson's Disease in Women: a Meta-analysis of Observational Studies. Behav Brain Res. 2017 09 29;335:103-110. PubMed PMID: 28743601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproductive factors and risk of Parkinson's disease in women: A meta-analysis of observational studies. AU - Lv,Menglian, AU - Zhang,Ying, AU - Chen,Guo-Chong, AU - Li,Guowei, AU - Rui,Yehua, AU - Qin,Liqiang, AU - Wan,Zhongxiao, Y1 - 2017/07/22/ PY - 2017/06/01/received PY - 2017/07/15/revised PY - 2017/07/18/accepted PY - 2017/7/27/pubmed PY - 2018/5/23/medline PY - 2017/7/27/entrez KW - Menopause KW - Meta-analysis KW - Oral contraceptives KW - Parity KW - Parkinson’s disease KW - Reproductive factors SP - 103 EP - 110 JF - Behavioural brain research JO - Behav Brain Res VL - 335 N2 - Evidence on the relationship between reproductive factors, use of oral contraceptives (OCs) and the incidence of Parkinson's disease (PD) remain inconclusive. The aim of this meta-analysis is to evaluate whether relevant reproductive factors including age at menarche, age at menopause, fertile lifespan, parity, type of menopause (surgical versus natural), and use of OCs are associated with risk of PD in women via random-effects model. PubMed and EMBASE database were used to search for case-control or cohort studies published before February17, 2017. 6 case-control and 5 cohort studies were included in the meta-analysis. The pooled relative risks (RRs) of PD risk were 1.00 (95% CI: 0.79-1.28) for use of OCs (ever versus never), 1.03 (95% CI: 0.84-1.26) for age at menarche, 0.98 (95% CI: 0.75-1.29) for age at menopause, 0.98(95% CI: 0.77-1.25) for fertile lifespan, 0.99(95% CI:0.0.79-1.25) for parity, 0.93 (95% CI:0.68-1.29) for type of menopause (surgical versus natural). In the subgroup analysis stratified by study design, age, caffeine intake and smoking, an inverse association was found between surgical menopause and risk of PD for those adjusting for caffeine intake (RR: 0.67, 95% CI: 0.45-0.99) and smoking (RR: 0.77, 95% CI: 0.63-0.94); while a positive association was found between surgical menopause and PD risk for those not adjusting for smoking (RR: 1.91, 95% CI: 1.29-2.83). In conclusion, our meta-analysis provided little epidemiological support for the role of reproductive factors in the incidence of PD. Whether surgical menopause is inversely associated with the risk of PD requires further explorations. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/28743601/Reproductive_factors_and_risk_of_Parkinson's_disease_in_women:_A_meta_analysis_of_observational_studies_ DB - PRIME DP - Unbound Medicine ER -