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Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts.
Phytother Res. 2017 Sep; 31(9):1384-1391.PR

Abstract

Litchi (Litchi chinensis Sonn.) is a famous fruit in south China, and it is also effective for chest tightness or chest pain, irritability, flatulence, epigastric pain and neuralgic pain, hernia pain and testicular swelling, cough, etc. It is valued because a great amount of polyphenol was found in litchi pericarp. In this paper, we got litchi pericarp pure extract by a simple purification method, then evaluated its activity to clear oxygen free radicals in vitro, and evaluated its myocardial protection effect in vivo through acute myocardial ischemia rat model. The results showed that the pure extract had protective effect on myocardial ischemia injury in a certain dose-effect relationship, which reflected in the electrocardiogram, myocardial pathological morphology and other indicators such as cardiac function enzymes, serum and myocardial antioxidant capacity, and eNOS, Bcl-2 and Bax gene expression. Furthermore, we analyzed the components of pure extract by UPLC-MS, ESI-MS and NMR. The main components of PLPE were procyanidin which were identified as procyanidin B2(1), (-)-epicatechin(2), epicatechin-(4β → 8,2β → O → 7)-epicatechin-(4β → 8)-epicatechin(3), A-type procyanidin trimer(4), B-type procyanidin dimer(5) and procyanidin A2(6).This study proved that litchi pericarp extract may have antioxidant activity and cardioprotection effect. It suggested that litchi pericarp may be good for cardiovascular disease. Copyright © 2017 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Guangdong Pharmaceutical University, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China. Key Laboratory for Advanced Drug Delivery Systems of Guangdong Province, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China. Key Laboratory for Advanced Drug Delivery Systems of Guangdong Province, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China. Key Laboratory for Advanced Drug Delivery Systems of Guangdong Province, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China.Guangdong Pharmaceutical University, Guangzhou, 510006, China. Key Laboratory for Advanced Drug Delivery Systems of Guangdong Province, Guangzhou, 510006, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28744920

Citation

Chen, Yanfen, et al. "Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts." Phytotherapy Research : PTR, vol. 31, no. 9, 2017, pp. 1384-1391.
Chen Y, Li H, Zhang S, et al. Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts. Phytother Res. 2017;31(9):1384-1391.
Chen, Y., Li, H., Zhang, S., Yang, C., Mai, Z., Hu, X., Gao, Z., & Deng, H. (2017). Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts. Phytotherapy Research : PTR, 31(9), 1384-1391. https://doi.org/10.1002/ptr.5865
Chen Y, et al. Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts. Phytother Res. 2017;31(9):1384-1391. PubMed PMID: 28744920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts. AU - Chen,Yanfen, AU - Li,Huanqing, AU - Zhang,Shu, AU - Yang,Chaoyan, AU - Mai,Ziying, AU - Hu,Xueyan, AU - Gao,Zhenhu, AU - Deng,Hong, Y1 - 2017/07/26/ PY - 2017/02/15/received PY - 2017/06/13/revised PY - 2017/06/14/accepted PY - 2017/7/27/pubmed PY - 2017/10/11/medline PY - 2017/7/27/entrez KW - anti-myocardial ischemia KW - antioxidation KW - components KW - litchi pericarp KW - pharmacological effect SP - 1384 EP - 1391 JF - Phytotherapy research : PTR JO - Phytother Res VL - 31 IS - 9 N2 - Litchi (Litchi chinensis Sonn.) is a famous fruit in south China, and it is also effective for chest tightness or chest pain, irritability, flatulence, epigastric pain and neuralgic pain, hernia pain and testicular swelling, cough, etc. It is valued because a great amount of polyphenol was found in litchi pericarp. In this paper, we got litchi pericarp pure extract by a simple purification method, then evaluated its activity to clear oxygen free radicals in vitro, and evaluated its myocardial protection effect in vivo through acute myocardial ischemia rat model. The results showed that the pure extract had protective effect on myocardial ischemia injury in a certain dose-effect relationship, which reflected in the electrocardiogram, myocardial pathological morphology and other indicators such as cardiac function enzymes, serum and myocardial antioxidant capacity, and eNOS, Bcl-2 and Bax gene expression. Furthermore, we analyzed the components of pure extract by UPLC-MS, ESI-MS and NMR. The main components of PLPE were procyanidin which were identified as procyanidin B2(1), (-)-epicatechin(2), epicatechin-(4β → 8,2β → O → 7)-epicatechin-(4β → 8)-epicatechin(3), A-type procyanidin trimer(4), B-type procyanidin dimer(5) and procyanidin A2(6).This study proved that litchi pericarp extract may have antioxidant activity and cardioprotection effect. It suggested that litchi pericarp may be good for cardiovascular disease. Copyright © 2017 John Wiley & Sons, Ltd. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/28744920/Anti_myocardial_Ischemia_Effect_and_Components_of_Litchi_Pericarp_Extracts_ DB - PRIME DP - Unbound Medicine ER -