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[Obesity-related glomerulopathy: Mechanisms of development, clinical course].
Ter Arkh 2017; 89(6):97-101TA

Abstract

Obesity and overweight are recognized as epidemics of non-communicable diseases in the 21st century. The kidneys are a target organ for obesity, damage to which is considered to be an independent risk factor for the development of renal failure. Obesity-related glomerulopathy (OGP) is one of the types of renal injury in obesity, which is characterized by the development of proteinuria in patients with a body mass index (BMI) of >30 kg/m2 in the absence of other causes of kidney damage. The pathogenesis of OGP is multifactorial. It is associated with intrarenal hemodynamic disorders - the development of renal hyperfiltration, the damaging action of adipose tissue hormones (hyperleptinemia, activation of the renin-angiotensin-aldosterone system, decreased production of adiponectin); with ectopic lipid accumulation in the kidney. The morphological pattern of OGP is characterized by a low glomerular density (oligonephronia) that leads to glomerular and tubular hypertrophy; by the development of perihilar focal segmental glomerulosclerosis (FSGS), obvious podocyte damages, and the development of a fatty kidney. The clinical picture of OGP is characterized by the slow and gradual development of albuminuria, not exceeding Stage A3 (300-1999 mg/day). Approximately one-third of patients develop partial nephrotic syndrome with massive proteinuria, but without edema and hypoproteinemia. Complete nephrotic syndrome is observed in not more than 6% of patients with OGP. In the course of the disease, 50% of patients develop hypertension and more than 80% do dyslipidemia. Stages IV-V chronic kidney disease may develop 20-30 years after the disease occurs.

Authors+Show Affiliations

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Pub Type(s)

Journal Article
Review

Language

rus

PubMed ID

28745696

Citation

Kutyrina, I M.. "[Obesity-related Glomerulopathy: Mechanisms of Development, Clinical Course]." Terapevticheskii Arkhiv, vol. 89, no. 6, 2017, pp. 97-101.
Kutyrina IM. [Obesity-related glomerulopathy: Mechanisms of development, clinical course]. Ter Arkh. 2017;89(6):97-101.
Kutyrina, I. M. (2017). [Obesity-related glomerulopathy: Mechanisms of development, clinical course]. Terapevticheskii Arkhiv, 89(6), pp. 97-101. doi:10.17116/terarkh201789697-101.
Kutyrina IM. [Obesity-related Glomerulopathy: Mechanisms of Development, Clinical Course]. Ter Arkh. 2017;89(6):97-101. PubMed PMID: 28745696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Obesity-related glomerulopathy: Mechanisms of development, clinical course]. A1 - Kutyrina,I M, PY - 2017/7/27/entrez PY - 2017/7/27/pubmed PY - 2017/12/1/medline KW - adipose tissue hormones KW - hyperfiltration KW - obesity KW - perihilar focal segmental glomerulosclerosis KW - podocytes SP - 97 EP - 101 JF - Terapevticheskii arkhiv JO - Ter. Arkh. VL - 89 IS - 6 N2 - Obesity and overweight are recognized as epidemics of non-communicable diseases in the 21st century. The kidneys are a target organ for obesity, damage to which is considered to be an independent risk factor for the development of renal failure. Obesity-related glomerulopathy (OGP) is one of the types of renal injury in obesity, which is characterized by the development of proteinuria in patients with a body mass index (BMI) of >30 kg/m2 in the absence of other causes of kidney damage. The pathogenesis of OGP is multifactorial. It is associated with intrarenal hemodynamic disorders - the development of renal hyperfiltration, the damaging action of adipose tissue hormones (hyperleptinemia, activation of the renin-angiotensin-aldosterone system, decreased production of adiponectin); with ectopic lipid accumulation in the kidney. The morphological pattern of OGP is characterized by a low glomerular density (oligonephronia) that leads to glomerular and tubular hypertrophy; by the development of perihilar focal segmental glomerulosclerosis (FSGS), obvious podocyte damages, and the development of a fatty kidney. The clinical picture of OGP is characterized by the slow and gradual development of albuminuria, not exceeding Stage A3 (300-1999 mg/day). Approximately one-third of patients develop partial nephrotic syndrome with massive proteinuria, but without edema and hypoproteinemia. Complete nephrotic syndrome is observed in not more than 6% of patients with OGP. In the course of the disease, 50% of patients develop hypertension and more than 80% do dyslipidemia. Stages IV-V chronic kidney disease may develop 20-30 years after the disease occurs. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/28745696/[Obesity-related_glomerulopathy:_Mechanisms_of_development,_clinical_course] L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -