Tags

Type your tag names separated by a space and hit enter

Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI.
Exp Anim. 2018 Feb 09; 67(1):23-29.EA

Abstract

To provide clear information on the cerebral regions according to peripheral neuropathy, the functional activation was investigated using manganese-enhanced magnetic resonance imaging (MEMRI). L5-spinal nerve ligation (SNL) was applied to the rats to induce neuropathic pain. Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment. The cerebral regions were investigated using a 4.7T MRI system in the sham, SNL, and GBP-treated SNL rats. Neuropathic pain was severely induced by SNL on the postoperative day 14, excepting the sham group. While MEMRI indicated many activation regions in the brain of SNL rats before GBP treatment, the activities were chronologically attenuated after GBP treatment. The brain regions relating SNL-induced neuropathic pain were as follows: the posterior association area of the parietal region, superior colliculus, inferior colliculus, primary somatosensory area, cingulate cortex, and cingulum bundle. SNL induced- neuropathic pain is transmitted to the primary somatosensory area and parietal region through the cingulum bundle and limbic system. These findings would be helpful for the understanding of neuropathic pain-associated process and be an accurate target for a relief of neuropathic pain.

Authors+Show Affiliations

R&D division, Metimedi Pharmaceuticals, Suite 908, 263 Central-ro Yeonsu-gu, Incheon 22006, Republic of Korea.Department of Biomedical Laboratory Science, College of Health and Medical Science, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28747592

Citation

Jeong, Keun-Yeong, and Ji-Hyuk Kang. "Investigation of Spinal Nerve Ligation-mediated Functional Activation of the Rat Brain Using Manganese-enhanced MRI." Experimental Animals, vol. 67, no. 1, 2018, pp. 23-29.
Jeong KY, Kang JH. Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. Exp Anim. 2018;67(1):23-29.
Jeong, K. Y., & Kang, J. H. (2018). Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. Experimental Animals, 67(1), 23-29. https://doi.org/10.1538/expanim.17-0033
Jeong KY, Kang JH. Investigation of Spinal Nerve Ligation-mediated Functional Activation of the Rat Brain Using Manganese-enhanced MRI. Exp Anim. 2018 Feb 9;67(1):23-29. PubMed PMID: 28747592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. AU - Jeong,Keun-Yeong, AU - Kang,Ji-Hyuk, Y1 - 2017/07/26/ PY - 2017/7/28/pubmed PY - 2018/6/23/medline PY - 2017/7/28/entrez KW - gabapentin KW - maganese-enhanced MRI KW - neuropathic pain KW - rat brain KW - spinal nerve ligation SP - 23 EP - 29 JF - Experimental animals JO - Exp Anim VL - 67 IS - 1 N2 - To provide clear information on the cerebral regions according to peripheral neuropathy, the functional activation was investigated using manganese-enhanced magnetic resonance imaging (MEMRI). L5-spinal nerve ligation (SNL) was applied to the rats to induce neuropathic pain. Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment. The cerebral regions were investigated using a 4.7T MRI system in the sham, SNL, and GBP-treated SNL rats. Neuropathic pain was severely induced by SNL on the postoperative day 14, excepting the sham group. While MEMRI indicated many activation regions in the brain of SNL rats before GBP treatment, the activities were chronologically attenuated after GBP treatment. The brain regions relating SNL-induced neuropathic pain were as follows: the posterior association area of the parietal region, superior colliculus, inferior colliculus, primary somatosensory area, cingulate cortex, and cingulum bundle. SNL induced- neuropathic pain is transmitted to the primary somatosensory area and parietal region through the cingulum bundle and limbic system. These findings would be helpful for the understanding of neuropathic pain-associated process and be an accurate target for a relief of neuropathic pain. SN - 1881-7122 UR - https://www.unboundmedicine.com/medline/citation/28747592/Investigation_of_spinal_nerve_ligation_mediated_functional_activation_of_the_rat_brain_using_manganese_enhanced_MRI_ L2 - https://dx.doi.org/10.1538/expanim.17-0033 DB - PRIME DP - Unbound Medicine ER -