Tags

Type your tag names separated by a space and hit enter

Head trauma and Parkinson's disease: results from an Italian case-control study.
Neurol Sci. 2017 Oct; 38(10):1835-1839.NS

Abstract

We evaluated the possible association between head trauma and Parkinson's disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movement disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Positive history of head trauma was considered only if the head trauma preceded the onset of PD. All cases and controls underwent a standard neurological examination. Adjusted ORs and 95% CI were estimated using multivariate analysis (logistic regression). Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. A positive history for head trauma was reported by 106 (21.5%) PD patients and by 62 (13.5%) healthy controls. Multivariate analysis (OR adjusted by age, sex, family history, coffee smoking, and alcohol consumption) showed a significant positive association between PD and head trauma with an adjusted OR of 1.50 (95%CI 1.04-2.17; p value 0.03). In agreement with literature data, our study supports the positive association between head trauma and PD.

Authors+Show Affiliations

Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università Degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy.Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università Degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy.Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università Degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy.Istituto di Bioimmagini e Fisiologia Molecolare - Consiglio Nazionale delle Ricerche, Catanzaro, Italy.Clinica Neurologica, Università "Magna Græcia" di Catanzaro, Catanzaro, Italy.Dipartimento di Scienze mediche di base, neuroscienze e organi di senso, Università di Bari, Bari, Italy.Dipartimento di Scienze mediche di base, neuroscienze e organi di senso, Università di Bari, Bari, Italy.Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy.Dipartimento di Neuroscienze, Università di Messina, Messina, Italy.Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Salerno, Italy.Istituto di Bioimmagini e Fisiologia Molecolare - Consiglio Nazionale delle Ricerche, Catanzaro, Italy. Clinica Neurologica, Università "Magna Græcia" di Catanzaro, Catanzaro, Italy.Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università Degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy. m.zappia@unict.it.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28748275

Citation

Nicoletti, Alessandra, et al. "Head Trauma and Parkinson's Disease: Results From an Italian Case-control Study." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 38, no. 10, 2017, pp. 1835-1839.
Nicoletti A, Vasta R, Mostile G, et al. Head trauma and Parkinson's disease: results from an Italian case-control study. Neurol Sci. 2017;38(10):1835-1839.
Nicoletti, A., Vasta, R., Mostile, G., Nicoletti, G., Arabia, G., Iliceto, G., Lamberti, P., Marconi, R., Morgante, L., Barone, P., Quattrone, A., & Zappia, M. (2017). Head trauma and Parkinson's disease: results from an Italian case-control study. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 38(10), 1835-1839. https://doi.org/10.1007/s10072-017-3076-5
Nicoletti A, et al. Head Trauma and Parkinson's Disease: Results From an Italian Case-control Study. Neurol Sci. 2017;38(10):1835-1839. PubMed PMID: 28748275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head trauma and Parkinson's disease: results from an Italian case-control study. AU - Nicoletti,Alessandra, AU - Vasta,Rosario, AU - Mostile,Giovanni, AU - Nicoletti,Giuseppe, AU - Arabia,Gennarina, AU - Iliceto,Giovanni, AU - Lamberti,Paolo, AU - Marconi,Roberto, AU - Morgante,Letterio, AU - Barone,Paolo, AU - Quattrone,Aldo, AU - Zappia,Mario, Y1 - 2017/07/26/ PY - 2017/05/05/received PY - 2017/07/16/accepted PY - 2017/7/28/pubmed PY - 2018/7/31/medline PY - 2017/7/28/entrez KW - Case-control study KW - Head trauma KW - Parkinson’s disease SP - 1835 EP - 1839 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 38 IS - 10 N2 - We evaluated the possible association between head trauma and Parkinson's disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movement disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Positive history of head trauma was considered only if the head trauma preceded the onset of PD. All cases and controls underwent a standard neurological examination. Adjusted ORs and 95% CI were estimated using multivariate analysis (logistic regression). Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. A positive history for head trauma was reported by 106 (21.5%) PD patients and by 62 (13.5%) healthy controls. Multivariate analysis (OR adjusted by age, sex, family history, coffee smoking, and alcohol consumption) showed a significant positive association between PD and head trauma with an adjusted OR of 1.50 (95%CI 1.04-2.17; p value 0.03). In agreement with literature data, our study supports the positive association between head trauma and PD. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/28748275/Head_trauma_and_Parkinson's_disease:_results_from_an_Italian_case_control_study_ L2 - https://link.springer.com/10.1007/s10072-017-3076-5 DB - PRIME DP - Unbound Medicine ER -