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Vitamin D levels and other biochemical parameters of mineral bone disorders and their association with diastolic dysfunction and left ventricular mass in young nondiabetic adult patients with chronic kidney disease.
Saudi J Kidney Dis Transpl. 2017 Jul-Aug; 28(4):758-763.SJ

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with end-stage renal disease. Chronic kidney disease (CKD)-associated cardiovascular mortality is more prevalent in those with diastolic heart failure and is an early predictor, while increased left ventricular mass (LVM) is a strong independent risk factor. Hypovitaminosis D is extensively being studied as a nontraditional risk factor for CVD. The aim of the present study is to look at the association of Vitamin D and other parameters of mineral bone disorder (MBD) with diastolic dysfunction and LVM in nondiabetic young adult patients with CKD. This was a hospital-based, cross-sectional observational study. Groups I and II comprised nondiabetic predialysis CKD patients (stage 4 and 5) and healthy controls, respectively. Groups IA and IB comprised cases with and without diastolic dysfunction, respectively. Vitamin D level was measured by enhanced chemiluminescence method and intact parathyroid hormone (iPTH) by electrochemiluminescence method. Parameters for diastolic function and LVM were assessed by Doppler echocardiography, tissue Doppler imaging, and M-mode echocardiography. Vitamin D level was significantly lower in Group I as compared to Group II. Diastolic dysfunction was present in 48.8% of the cases and was significantly associated with serum phosphorus and calcium-phosphorous product, but not with Vitamin D level. A statistically significant positive correlation between LVM and iPTH was found in our study. Hyperphosphatemia and high calcium-phosphorous product can be a better early predictor of diastolic dysfunction than Vitamin D while secondary hyperpara-thyroidism with increased LVM may be a bad prognostic marker.

Authors+Show Affiliations

Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India.Department of Nephrology, King George's Medical University, Lucknow, Uttar Pradesh, India.Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India.Division of Clinical and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28748877

Citation

Sonkar, Satyendra Kumar, et al. "Vitamin D Levels and Other Biochemical Parameters of Mineral Bone Disorders and Their Association With Diastolic Dysfunction and Left Ventricular Mass in Young Nondiabetic Adult Patients With Chronic Kidney Disease." Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 28, no. 4, 2017, pp. 758-763.
Sonkar SK, Bhutani M, Sonkar GK, et al. Vitamin D levels and other biochemical parameters of mineral bone disorders and their association with diastolic dysfunction and left ventricular mass in young nondiabetic adult patients with chronic kidney disease. Saudi J Kidney Dis Transpl. 2017;28(4):758-763.
Sonkar, S. K., Bhutani, M., Sonkar, G. K., Pandey, S. K., Chandra, S., & Bhosale, V. (2017). Vitamin D levels and other biochemical parameters of mineral bone disorders and their association with diastolic dysfunction and left ventricular mass in young nondiabetic adult patients with chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 28(4), 758-763.
Sonkar SK, et al. Vitamin D Levels and Other Biochemical Parameters of Mineral Bone Disorders and Their Association With Diastolic Dysfunction and Left Ventricular Mass in Young Nondiabetic Adult Patients With Chronic Kidney Disease. Saudi J Kidney Dis Transpl. 2017 Jul-Aug;28(4):758-763. PubMed PMID: 28748877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D levels and other biochemical parameters of mineral bone disorders and their association with diastolic dysfunction and left ventricular mass in young nondiabetic adult patients with chronic kidney disease. AU - Sonkar,Satyendra Kumar, AU - Bhutani,Mohit, AU - Sonkar,Gyanendra Kumar, AU - Pandey,Sant Kumar, AU - Chandra,Sharad, AU - Bhosale,Vivek, PY - 2017/7/28/entrez PY - 2017/7/28/pubmed PY - 2019/7/2/medline SP - 758 EP - 763 JF - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia JO - Saudi J Kidney Dis Transpl VL - 28 IS - 4 N2 - Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with end-stage renal disease. Chronic kidney disease (CKD)-associated cardiovascular mortality is more prevalent in those with diastolic heart failure and is an early predictor, while increased left ventricular mass (LVM) is a strong independent risk factor. Hypovitaminosis D is extensively being studied as a nontraditional risk factor for CVD. The aim of the present study is to look at the association of Vitamin D and other parameters of mineral bone disorder (MBD) with diastolic dysfunction and LVM in nondiabetic young adult patients with CKD. This was a hospital-based, cross-sectional observational study. Groups I and II comprised nondiabetic predialysis CKD patients (stage 4 and 5) and healthy controls, respectively. Groups IA and IB comprised cases with and without diastolic dysfunction, respectively. Vitamin D level was measured by enhanced chemiluminescence method and intact parathyroid hormone (iPTH) by electrochemiluminescence method. Parameters for diastolic function and LVM were assessed by Doppler echocardiography, tissue Doppler imaging, and M-mode echocardiography. Vitamin D level was significantly lower in Group I as compared to Group II. Diastolic dysfunction was present in 48.8% of the cases and was significantly associated with serum phosphorus and calcium-phosphorous product, but not with Vitamin D level. A statistically significant positive correlation between LVM and iPTH was found in our study. Hyperphosphatemia and high calcium-phosphorous product can be a better early predictor of diastolic dysfunction than Vitamin D while secondary hyperpara-thyroidism with increased LVM may be a bad prognostic marker. SN - 1319-2442 UR - https://www.unboundmedicine.com/medline/citation/28748877/Vitamin_D_levels_and_other_biochemical_parameters_of_mineral_bone_disorders_and_their_association_with_diastolic_dysfunction_and_left_ventricular_mass_in_young_nondiabetic_adult_patients_with_chronic_kidney_disease_ L2 - http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=4;spage=758;epage=763;aulast=Sonkar DB - PRIME DP - Unbound Medicine ER -