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Dietary Modulation of Oxidative Stress in Alzheimer's Disease.
Int J Mol Sci. 2017 Jul 21; 18(7)IJ

Abstract

Cells generate unpaired electrons, typically via oxygen- or nitrogen-based by-products during normal cellular respiration and under stressed situations. These pro-oxidant molecules are highly unstable and may oxidize surrounding cellular macromolecules. Under normal conditions, the reactive oxygen or nitrogen species can be beneficial to cell survival and function by destroying and degrading pathogens or antigens. However, excessive generation and accumulation of the reactive pro-oxidant species over time can damage proteins, lipids, carbohydrates, and nucleic acids. Over time, this oxidative stress can contribute to a range of aging-related degenerative diseases such as cancer, diabetes, macular degeneration, and Alzheimer's, and Parkinson's diseases. It is well accepted that natural compounds, including vitamins A, C, and E, β-carotene, and minerals found in fruits and vegetables are powerful anti-oxidants that offer health benefits against several different oxidative stress induced degenerative diseases, including Alzheimer's disease (AD). There is increasing interest in developing anti-oxidative therapeutics to prevent AD. There are contradictory and inconsistent reports on the possible benefits of anti-oxidative supplements; however, fruits and vegetables enriched with multiple anti-oxidants (e.g., flavonoids and polyphenols) and minerals may be highly effective in attenuating the harmful effects of oxidative stress. As the physiological activation of either protective or destructive pro-oxidant behavior remains relatively unclear, it is not straightforward to relate the efficacy of dietary anti-oxidants in disease prevention. Here, we review oxidative stress mediated toxicity associated with AD and highlight the modulatory roles of natural dietary anti-oxidants in preventing AD.

Authors+Show Affiliations

Department of Chemical and Biological Engineering and the Center for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA. athapa@unm.edu.Department of Chemical and Biological Engineering and the Center for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA. ncarroll@unm.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28753984

Citation

Thapa, Arjun, and Nick J. Carroll. "Dietary Modulation of Oxidative Stress in Alzheimer's Disease." International Journal of Molecular Sciences, vol. 18, no. 7, 2017.
Thapa A, Carroll NJ. Dietary Modulation of Oxidative Stress in Alzheimer's Disease. Int J Mol Sci. 2017;18(7).
Thapa, A., & Carroll, N. J. (2017). Dietary Modulation of Oxidative Stress in Alzheimer's Disease. International Journal of Molecular Sciences, 18(7). https://doi.org/10.3390/ijms18071583
Thapa A, Carroll NJ. Dietary Modulation of Oxidative Stress in Alzheimer's Disease. Int J Mol Sci. 2017 Jul 21;18(7) PubMed PMID: 28753984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Modulation of Oxidative Stress in Alzheimer's Disease. AU - Thapa,Arjun, AU - Carroll,Nick J, Y1 - 2017/07/21/ PY - 2017/06/16/received PY - 2017/07/03/revised PY - 2017/07/12/accepted PY - 2017/7/30/entrez PY - 2017/7/30/pubmed PY - 2018/4/27/medline KW - Alzheimer’s disease KW - anti-oxidant KW - degenerative disease KW - diet KW - flavonoid KW - oxidative stress KW - polyphenol KW - pro-oxidant KW - protective function JF - International journal of molecular sciences JO - Int J Mol Sci VL - 18 IS - 7 N2 - Cells generate unpaired electrons, typically via oxygen- or nitrogen-based by-products during normal cellular respiration and under stressed situations. These pro-oxidant molecules are highly unstable and may oxidize surrounding cellular macromolecules. Under normal conditions, the reactive oxygen or nitrogen species can be beneficial to cell survival and function by destroying and degrading pathogens or antigens. However, excessive generation and accumulation of the reactive pro-oxidant species over time can damage proteins, lipids, carbohydrates, and nucleic acids. Over time, this oxidative stress can contribute to a range of aging-related degenerative diseases such as cancer, diabetes, macular degeneration, and Alzheimer's, and Parkinson's diseases. It is well accepted that natural compounds, including vitamins A, C, and E, β-carotene, and minerals found in fruits and vegetables are powerful anti-oxidants that offer health benefits against several different oxidative stress induced degenerative diseases, including Alzheimer's disease (AD). There is increasing interest in developing anti-oxidative therapeutics to prevent AD. There are contradictory and inconsistent reports on the possible benefits of anti-oxidative supplements; however, fruits and vegetables enriched with multiple anti-oxidants (e.g., flavonoids and polyphenols) and minerals may be highly effective in attenuating the harmful effects of oxidative stress. As the physiological activation of either protective or destructive pro-oxidant behavior remains relatively unclear, it is not straightforward to relate the efficacy of dietary anti-oxidants in disease prevention. Here, we review oxidative stress mediated toxicity associated with AD and highlight the modulatory roles of natural dietary anti-oxidants in preventing AD. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/28753984/Dietary_Modulation_of_Oxidative_Stress_in_Alzheimer's_Disease_ L2 - https://www.mdpi.com/resolver?pii=ijms18071583 DB - PRIME DP - Unbound Medicine ER -