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Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis.
Mycopathologia. 2018 Apr; 183(2):479-484.M

Abstract

A 6-year-old, spayed female cat was presented with acute respiratory signs and pleural effusion. Computed tomography scan revealed a large, lobulated mass effect in the ventral right hemithorax with concurrent sternal lymphadenopathy. A cytologic sample of the mass contained pyogranulomatous inflammation, necrotic material, and abundant yeast structures that lacked a distinct capsule and demonstrated rare pseudohyphal forms. Fungal culture and biochemical testing identified the yeast as Cryptococcus albidus, with susceptibility to all antifungal agents tested. However, subsequent 18S PCR identified 99% homology with a strain of Cryptococcus neoformans and only 92% homology with C. albidus. The patient responded well to fluconazole therapy unlike the only known previous report of C. albidus in a cat. The unusual cytologic morphology in this case underscores the need for ancillary testing apart from microscopy for fungal identification. Though C. albidus should be considered as a potential feline pathogen, confirmation with PCR is recommended when such rare non-neoformans species are encountered.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Evans SJM
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University, 1644 Campus Delivery, Fort Collins, CO, 80523-1644, USA. samantha.jm.evans@colostate.edu.
Jones K
Virginia Veterinary Specialists, Charlottesville, VA, USA.
Moore AR
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University, 1644 Campus Delivery, Fort Collins, CO, 80523-1644, USA.

MeSH

AnimalsAntifungal AgentsCat DiseasesCatsCluster AnalysisCryptococcosisCryptococcusCytological TechniquesDNA, FungalDNA, RibosomalFemaleFluconazoleMicrobial Sensitivity TestsMicroscopyMycological Typing TechniquesPhylogenyPleural EffusionRNA, Ribosomal, 18SRadiography, ThoracicSequence Analysis, DNATreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28756537

Citation

Evans, S J M., et al. "Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis." Mycopathologia, vol. 183, no. 2, 2018, pp. 479-484.
Evans SJM, Jones K, Moore AR. Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis. Mycopathologia. 2018;183(2):479-484.
Evans, S. J. M., Jones, K., & Moore, A. R. (2018). Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis. Mycopathologia, 183(2), 479-484. https://doi.org/10.1007/s11046-017-0183-z
Evans SJM, Jones K, Moore AR. Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis. Mycopathologia. 2018;183(2):479-484. PubMed PMID: 28756537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis. AU - Evans,S J M, AU - Jones,K, AU - Moore,A R, Y1 - 2017/07/29/ PY - 2017/02/01/received PY - 2017/07/20/accepted PY - 2017/8/2/pubmed PY - 2018/8/25/medline PY - 2017/7/31/entrez KW - Cat KW - Cryptococcus albidus KW - Cryptococcus neoformans KW - Fungal morphology KW - Speciation SP - 479 EP - 484 JF - Mycopathologia JO - Mycopathologia VL - 183 IS - 2 N2 - A 6-year-old, spayed female cat was presented with acute respiratory signs and pleural effusion. Computed tomography scan revealed a large, lobulated mass effect in the ventral right hemithorax with concurrent sternal lymphadenopathy. A cytologic sample of the mass contained pyogranulomatous inflammation, necrotic material, and abundant yeast structures that lacked a distinct capsule and demonstrated rare pseudohyphal forms. Fungal culture and biochemical testing identified the yeast as Cryptococcus albidus, with susceptibility to all antifungal agents tested. However, subsequent 18S PCR identified 99% homology with a strain of Cryptococcus neoformans and only 92% homology with C. albidus. The patient responded well to fluconazole therapy unlike the only known previous report of C. albidus in a cat. The unusual cytologic morphology in this case underscores the need for ancillary testing apart from microscopy for fungal identification. Though C. albidus should be considered as a potential feline pathogen, confirmation with PCR is recommended when such rare non-neoformans species are encountered. SN - 1573-0832 UR - https://www.unboundmedicine.com/medline/citation/28756537/Atypical_Morphology_and_Disparate_Speciation_in_a_Case_of_Feline_Cryptococcosis_ L2 - https://dx.doi.org/10.1007/s11046-017-0183-z DB - PRIME DP - Unbound Medicine ER -