Tags

Type your tag names separated by a space and hit enter

Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study.
Osteoarthritis Cartilage. 2017 12; 25(12):1962-1968.OC

Abstract

OBJECTIVE

While cross-sectional and retrospective case-control studies suggest that gout is associated with knee osteoarthritis (KOA), no prospective study has evaluated the risk of total knee replacement (TKR) for KOA in association with gout. We prospectively evaluated the association between gout and the risk of TKR due to severe KOA.

DESIGN

We used data from the Singapore Chinese Health Study (SCHS), a prospective cohort with 63,257 Chinese adults aged 45-74 years at recruitment (1993-1998). Self-report of physician-diagnosed gout was enquired at follow-up I interview (1999-2004) from 52,322 subjects. TKR cases for KOA after follow-up I were identified via linkage with nationwide hospital discharge database through 31 December 2011. Multivariable Cox proportional hazards regression model was applied with adjustment for potential risk factors of KOA.

RESULTS

Among 51,858 subjects (22,180 men and 29,678 women) included in this analysis, after average 9.7 follow-up years, there were 1,435 cases of TKR. Gout was associated with 39% higher risk of TKR in women [hazard ratio (HR) 1.39; 95% confidence interval (CI) 1.08-1.79] but not in men (HR 0.78; 95% CI 0.49-1.23). The positive gout-TKR association in women remained after excluding participants with self-reported history of arthritis (HR 1.57; 95% CI 1.04-2.37). This association was stronger in women who were lean (body mass index [BMI] < 23 kg/m2) (HR 2.17; 95% CI 1.30-3.64) compared to their heavier counterparts (Pinteraction = 0.016).

CONCLUSION

Gout is associated with risk of severe KOA, especially in lean women, suggesting the crystal arthritis may play a role in the pathogenesis or progression of OA.

Authors+Show Affiliations

University Medicine Cluster, Division of Rheumatology, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. Electronic address: gim_gee_teng@nuhs.edu.sg.Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School Singapore, Singapore. Electronic address: katy.leung.y.y@singhealth.com.sg.Epidemiology & Disease Control Division, Ministry of Health, Singapore. Electronic address: ANG_Li_Wei@moh.gov.sg.Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: yuanj@upmc.edu.Duke-NUS Medical School Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. Electronic address: woonpuay.koh@duke-nus.edu.sg.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28757187

Citation

Teng, G G., et al. "Gout and Risk of Knee Replacement for Severe Knee Osteoarthritis in the Singapore Chinese Health Study." Osteoarthritis and Cartilage, vol. 25, no. 12, 2017, pp. 1962-1968.
Teng GG, Leung YY, Ang LW, et al. Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study. Osteoarthritis Cartilage. 2017;25(12):1962-1968.
Teng, G. G., Leung, Y. Y., Ang, L. W., Yuan, J. M., & Koh, W. P. (2017). Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study. Osteoarthritis and Cartilage, 25(12), 1962-1968. https://doi.org/10.1016/j.joca.2017.07.017
Teng GG, et al. Gout and Risk of Knee Replacement for Severe Knee Osteoarthritis in the Singapore Chinese Health Study. Osteoarthritis Cartilage. 2017;25(12):1962-1968. PubMed PMID: 28757187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study. AU - Teng,G G, AU - Leung,Y Y, AU - Ang,L-W, AU - Yuan,J-M, AU - Koh,W-P, Y1 - 2017/07/27/ PY - 2017/02/08/received PY - 2017/05/15/revised PY - 2017/07/19/accepted PY - 2017/8/2/pubmed PY - 2018/7/19/medline PY - 2017/8/1/entrez KW - Chinese KW - Gout KW - Knee osteoarthritis KW - Total knee replacement SP - 1962 EP - 1968 JF - Osteoarthritis and cartilage JO - Osteoarthritis Cartilage VL - 25 IS - 12 N2 - OBJECTIVE: While cross-sectional and retrospective case-control studies suggest that gout is associated with knee osteoarthritis (KOA), no prospective study has evaluated the risk of total knee replacement (TKR) for KOA in association with gout. We prospectively evaluated the association between gout and the risk of TKR due to severe KOA. DESIGN: We used data from the Singapore Chinese Health Study (SCHS), a prospective cohort with 63,257 Chinese adults aged 45-74 years at recruitment (1993-1998). Self-report of physician-diagnosed gout was enquired at follow-up I interview (1999-2004) from 52,322 subjects. TKR cases for KOA after follow-up I were identified via linkage with nationwide hospital discharge database through 31 December 2011. Multivariable Cox proportional hazards regression model was applied with adjustment for potential risk factors of KOA. RESULTS: Among 51,858 subjects (22,180 men and 29,678 women) included in this analysis, after average 9.7 follow-up years, there were 1,435 cases of TKR. Gout was associated with 39% higher risk of TKR in women [hazard ratio (HR) 1.39; 95% confidence interval (CI) 1.08-1.79] but not in men (HR 0.78; 95% CI 0.49-1.23). The positive gout-TKR association in women remained after excluding participants with self-reported history of arthritis (HR 1.57; 95% CI 1.04-2.37). This association was stronger in women who were lean (body mass index [BMI] < 23 kg/m2) (HR 2.17; 95% CI 1.30-3.64) compared to their heavier counterparts (Pinteraction = 0.016). CONCLUSION: Gout is associated with risk of severe KOA, especially in lean women, suggesting the crystal arthritis may play a role in the pathogenesis or progression of OA. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/28757187/Gout_and_risk_of_knee_replacement_for_severe_knee_osteoarthritis_in_the_Singapore_Chinese_Health_Study_ DB - PRIME DP - Unbound Medicine ER -