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Effect of a 12-hour subcutaneous infusion of somatostatin-14 on blood glucose, insulin and glucagon levels in healthy subjects and insulin dependent diabetics.
Biomed Pharmacother. 1986; 40(2):61-4.BP

Abstract

We compared the influence of a 12-hour subcutaneous infusion of somatostatin-14 on glucose homeostasis in two normal subjects and two insulin-dependent diabetics (IDD). In all cases, somatostatin infusion led to a decrease of blood glucose during the first hours. The diabetogenic effect of somatostatin was confirmed in normal subjects. Postprandial blood glucose response was exaggerated in one insulin-dependent diabetic while in the other, glucose tolerance was improved. Unexpected high levels of immunoreactive somatostatin were measured in insulin-dependent diabetic patients. They might be due to a decreased somatostatin catabolism.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2875745

Citation

Villaume, C, et al. "Effect of a 12-hour Subcutaneous Infusion of Somatostatin-14 On Blood Glucose, Insulin and Glucagon Levels in Healthy Subjects and Insulin Dependent Diabetics." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 40, no. 2, 1986, pp. 61-4.
Villaume C, Beck B, Kolopp M, et al. Effect of a 12-hour subcutaneous infusion of somatostatin-14 on blood glucose, insulin and glucagon levels in healthy subjects and insulin dependent diabetics. Biomed Pharmacother. 1986;40(2):61-4.
Villaume, C., Beck, B., Kolopp, M., Toussain, P., & Debry, G. (1986). Effect of a 12-hour subcutaneous infusion of somatostatin-14 on blood glucose, insulin and glucagon levels in healthy subjects and insulin dependent diabetics. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 40(2), 61-4.
Villaume C, et al. Effect of a 12-hour Subcutaneous Infusion of Somatostatin-14 On Blood Glucose, Insulin and Glucagon Levels in Healthy Subjects and Insulin Dependent Diabetics. Biomed Pharmacother. 1986;40(2):61-4. PubMed PMID: 2875745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a 12-hour subcutaneous infusion of somatostatin-14 on blood glucose, insulin and glucagon levels in healthy subjects and insulin dependent diabetics. AU - Villaume,C, AU - Beck,B, AU - Kolopp,M, AU - Toussain,P, AU - Debry,G, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 61 EP - 4 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 40 IS - 2 N2 - We compared the influence of a 12-hour subcutaneous infusion of somatostatin-14 on glucose homeostasis in two normal subjects and two insulin-dependent diabetics (IDD). In all cases, somatostatin infusion led to a decrease of blood glucose during the first hours. The diabetogenic effect of somatostatin was confirmed in normal subjects. Postprandial blood glucose response was exaggerated in one insulin-dependent diabetic while in the other, glucose tolerance was improved. Unexpected high levels of immunoreactive somatostatin were measured in insulin-dependent diabetic patients. They might be due to a decreased somatostatin catabolism. SN - 0753-3322 UR - https://www.unboundmedicine.com/medline/citation/2875745/Effect_of_a_12_hour_subcutaneous_infusion_of_somatostatin_14_on_blood_glucose_insulin_and_glucagon_levels_in_healthy_subjects_and_insulin_dependent_diabetics_ DB - PRIME DP - Unbound Medicine ER -