Tags

Type your tag names separated by a space and hit enter

Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway.
Neurochem Res. 2017 Nov; 42(11):3233-3244.NR

Abstract

Preliminary studies conducted in our laboratory have confirmed that Bacopaside I (BS-I), a saponin compound isolated from Bacopa monnieri, displayed antidepressant-like activity in the mouse behavioral despair model. The present investigation aimed to verify the antidepressant-like action of BS-I using a mouse model of behavioral deficits induced by chronic unpredictable mild stress (CUMS) and further probe its underlying mechanism of action. Mice were exposed to CUMS for a period of 5 consecutive weeks to induce depression-like behavior. Then, oral gavage administrations with vehicle (model group), fluoxetine (12 mg/kg, positive group) or BS-I (5, 15, 45 mg/kg, treated group) once daily were started during the last two weeks of CUMS procedure. The results showed that BS-I significantly ameliorated CUMS-induced depression-like behaviors in mice, as characterized by an elevated sucrose consumption in the sucrose preference test and reduced immobility time without affecting spontaneous locomotor activity in the forced swimming test, tail suspension test and open field test. It was also found that BS-I treatment reversed the increased level of plasma corticosterone and decreased mRNA and protein expressions of glucocorticoid receptor induced by CUMS exposure, indicating that hypothalamic-pituitary-adrenal (HPA) axis hyperactivity of CUMS-exposed mice was restored by BS-I treatment. Furthermore, chronic administration of BS-I elevated expression levels of brain-derived neurotrophic factor (BDNF) (mRNA and protein) and activated the phosphorylation of extracellular signal-regulated kinase and cAMP response element-binding protein in the hippocampus and prefrontal cortex in mice subjected to CUMS procedure. Taken together, these results indicated that BS-I exhibited an obvious antidepressant-like effect in mouse model of CUMS-induced depression that was mediated, at least in part, by modulating HPA hyperactivity and activating BDNF signaling pathway.

Authors+Show Affiliations

School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.Institute of Immunology, Second Military Medical University, Shanghai, 200433, China.School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China.School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. liuxinru@hotmail.co.uk.School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. wdzhangy@hotmail.com. Institute of Interdisciplinary Complex Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. wdzhangy@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28758176

Citation

Zu, Xianpeng, et al. "Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress By Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway." Neurochemical Research, vol. 42, no. 11, 2017, pp. 3233-3244.
Zu X, Zhang M, Li W, et al. Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway. Neurochem Res. 2017;42(11):3233-3244.
Zu, X., Zhang, M., Li, W., Xie, H., Lin, Z., Yang, N., Liu, X., & Zhang, W. (2017). Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway. Neurochemical Research, 42(11), 3233-3244. https://doi.org/10.1007/s11064-017-2360-3
Zu X, et al. Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress By Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway. Neurochem Res. 2017;42(11):3233-3244. PubMed PMID: 28758176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway. AU - Zu,Xianpeng, AU - Zhang,Mingjian, AU - Li,Wencai, AU - Xie,Haisheng, AU - Lin,Zhang, AU - Yang,Niao, AU - Liu,Xinru, AU - Zhang,Weidong, Y1 - 2017/07/31/ PY - 2017/04/09/received PY - 2017/07/15/accepted PY - 2017/06/28/revised PY - 2017/8/2/pubmed PY - 2018/6/27/medline PY - 2017/8/1/entrez KW - Antidepressant-like effect KW - Bacopaside I KW - Brain-derived neurotrophic factor KW - Chronic unpredictable mild stress KW - Hypothalamic–pituitary–adrenal axis SP - 3233 EP - 3244 JF - Neurochemical research JO - Neurochem. Res. VL - 42 IS - 11 N2 - Preliminary studies conducted in our laboratory have confirmed that Bacopaside I (BS-I), a saponin compound isolated from Bacopa monnieri, displayed antidepressant-like activity in the mouse behavioral despair model. The present investigation aimed to verify the antidepressant-like action of BS-I using a mouse model of behavioral deficits induced by chronic unpredictable mild stress (CUMS) and further probe its underlying mechanism of action. Mice were exposed to CUMS for a period of 5 consecutive weeks to induce depression-like behavior. Then, oral gavage administrations with vehicle (model group), fluoxetine (12 mg/kg, positive group) or BS-I (5, 15, 45 mg/kg, treated group) once daily were started during the last two weeks of CUMS procedure. The results showed that BS-I significantly ameliorated CUMS-induced depression-like behaviors in mice, as characterized by an elevated sucrose consumption in the sucrose preference test and reduced immobility time without affecting spontaneous locomotor activity in the forced swimming test, tail suspension test and open field test. It was also found that BS-I treatment reversed the increased level of plasma corticosterone and decreased mRNA and protein expressions of glucocorticoid receptor induced by CUMS exposure, indicating that hypothalamic-pituitary-adrenal (HPA) axis hyperactivity of CUMS-exposed mice was restored by BS-I treatment. Furthermore, chronic administration of BS-I elevated expression levels of brain-derived neurotrophic factor (BDNF) (mRNA and protein) and activated the phosphorylation of extracellular signal-regulated kinase and cAMP response element-binding protein in the hippocampus and prefrontal cortex in mice subjected to CUMS procedure. Taken together, these results indicated that BS-I exhibited an obvious antidepressant-like effect in mouse model of CUMS-induced depression that was mediated, at least in part, by modulating HPA hyperactivity and activating BDNF signaling pathway. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/28758176/Antidepressant_like_Effect_of_Bacopaside_I_in_Mice_Exposed_to_Chronic_Unpredictable_Mild_Stress_by_Modulating_the_Hypothalamic_Pituitary_Adrenal_Axis_Function_and_Activating_BDNF_Signaling_Pathway_ L2 - https://doi.org/10.1007/s11064-017-2360-3 DB - PRIME DP - Unbound Medicine ER -