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Giant Viruses of Amoebae: A Journey Through Innovative Research and Paradigm Changes.
Annu Rev Virol. 2017 09 29; 4(1):61-85.AR

Abstract

Giant viruses of amoebae were discovered serendipitously in 2003; they are visible via optical microscopy, making them bona fide microbes. Their lifestyle, structure, and genomes break the mold of classical viruses. Giant viruses of amoebae are complex microorganisms. Their genomes harbor between 444 and 2,544 genes, including many that are unique to viruses, and encode translation components; their virions contain >100 proteins as well as mRNAs. Mimiviruses have a specific mobilome, including virophages, provirophages, and transpovirons, and can resist virophages through a system known as MIMIVIRE (mimivirus virophage resistance element). Giant viruses of amoebae bring upheaval to the definition of viruses and tend to separate the current virosphere into two categories: very simple viruses and viruses with complexity similar to that of other microbes. This new paradigm is propitious for enhanced detection and characterization of giant viruses of amoebae, and a particular focus on their role in humans is warranted.

Authors+Show Affiliations

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille (AP-HM), 13005 Marseille, France; email: didier.raoult@gmail.com.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille (AP-HM), 13005 Marseille, France; email: didier.raoult@gmail.com.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille (AP-HM), 13005 Marseille, France; email: didier.raoult@gmail.com.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28759330

Citation

Colson, Philippe, et al. "Giant Viruses of Amoebae: a Journey Through Innovative Research and Paradigm Changes." Annual Review of Virology, vol. 4, no. 1, 2017, pp. 61-85.
Colson P, La Scola B, Raoult D. Giant Viruses of Amoebae: A Journey Through Innovative Research and Paradigm Changes. Annu Rev Virol. 2017;4(1):61-85.
Colson, P., La Scola, B., & Raoult, D. (2017). Giant Viruses of Amoebae: A Journey Through Innovative Research and Paradigm Changes. Annual Review of Virology, 4(1), 61-85. https://doi.org/10.1146/annurev-virology-101416-041816
Colson P, La Scola B, Raoult D. Giant Viruses of Amoebae: a Journey Through Innovative Research and Paradigm Changes. Annu Rev Virol. 2017 09 29;4(1):61-85. PubMed PMID: 28759330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Giant Viruses of Amoebae: A Journey Through Innovative Research and Paradigm Changes. AU - Colson,Philippe, AU - La Scola,Bernard, AU - Raoult,Didier, Y1 - 2017/07/31/ PY - 2017/8/2/pubmed PY - 2017/10/28/medline PY - 2017/8/1/entrez KW - Megavirales KW - amoeba KW - giant virus KW - mimivirus KW - virophage SP - 61 EP - 85 JF - Annual review of virology JO - Annu Rev Virol VL - 4 IS - 1 N2 - Giant viruses of amoebae were discovered serendipitously in 2003; they are visible via optical microscopy, making them bona fide microbes. Their lifestyle, structure, and genomes break the mold of classical viruses. Giant viruses of amoebae are complex microorganisms. Their genomes harbor between 444 and 2,544 genes, including many that are unique to viruses, and encode translation components; their virions contain >100 proteins as well as mRNAs. Mimiviruses have a specific mobilome, including virophages, provirophages, and transpovirons, and can resist virophages through a system known as MIMIVIRE (mimivirus virophage resistance element). Giant viruses of amoebae bring upheaval to the definition of viruses and tend to separate the current virosphere into two categories: very simple viruses and viruses with complexity similar to that of other microbes. This new paradigm is propitious for enhanced detection and characterization of giant viruses of amoebae, and a particular focus on their role in humans is warranted. SN - 2327-0578 UR - https://www.unboundmedicine.com/medline/citation/28759330/Giant_Viruses_of_Amoebae:_A_Journey_Through_Innovative_Research_and_Paradigm_Changes_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev-virology-101416-041816?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -