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Oral contraceptive use and breast cancer in young women. A joint national case-control study in Sweden and Norway.
Lancet. 1986 Sep 20; 2(8508):650-4.Lct

Abstract

The possible association between oral contraceptive (OC) use and the risk of breast cancer developing before the age of 45 was investigated by means of a population based case-control study in Sweden and Norway. Information was obtained by personal interview from 422 (89.2%) of all eligible patients with a newly diagnosed breast cancer from May, 1984, to May, 1985, and from 722 (80.6%) of all contacted age-matched controls. A multivariate analysis, which accounted for several possible confounding factors, revealed a significant (p = 0.03) association between total duration of OC use and breast cancer risk. The relative risk (RR) of breast cancer after 12 or more years of OC use was 2.2 (1.2-4.0). OC use for more than 7 years before first full-term pregnancy entailed an increased breast cancer risk (RR = 2.0 [1.0-4.2]) which was of borderline significance. When total duration of use was considered, the risk of breast cancer was virtually unrelated to age at first OC use and latency from first use. The results suggest that long-term use of OCs may increase the risk of breast cancer in young women.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2876135

Citation

Meirik, O, et al. "Oral Contraceptive Use and Breast Cancer in Young Women. a Joint National Case-control Study in Sweden and Norway." Lancet (London, England), vol. 2, no. 8508, 1986, pp. 650-4.
Meirik O, Lund E, Adami HO, et al. Oral contraceptive use and breast cancer in young women. A joint national case-control study in Sweden and Norway. Lancet. 1986;2(8508):650-4.
Meirik, O., Lund, E., Adami, H. O., Bergström, R., Christoffersen, T., & Bergsjö, P. (1986). Oral contraceptive use and breast cancer in young women. A joint national case-control study in Sweden and Norway. Lancet (London, England), 2(8508), 650-4.
Meirik O, et al. Oral Contraceptive Use and Breast Cancer in Young Women. a Joint National Case-control Study in Sweden and Norway. Lancet. 1986 Sep 20;2(8508):650-4. PubMed PMID: 2876135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptive use and breast cancer in young women. A joint national case-control study in Sweden and Norway. AU - Meirik,O, AU - Lund,E, AU - Adami,H O, AU - Bergström,R, AU - Christoffersen,T, AU - Bergsjö,P, PY - 1986/9/20/pubmed PY - 1986/9/20/medline PY - 1986/9/20/entrez KW - Breast Cancer KW - Cancer KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Neoplasms KW - Northern Europe KW - Norway KW - Oral Contraceptives--side effects KW - Population At Risk KW - Research Methodology KW - Scandinavia KW - Studies KW - Sweden SP - 650 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8508 N2 - The possible association between oral contraceptive (OC) use and the risk of breast cancer developing before the age of 45 was investigated by means of a population based case-control study in Sweden and Norway. Information was obtained by personal interview from 422 (89.2%) of all eligible patients with a newly diagnosed breast cancer from May, 1984, to May, 1985, and from 722 (80.6%) of all contacted age-matched controls. A multivariate analysis, which accounted for several possible confounding factors, revealed a significant (p = 0.03) association between total duration of OC use and breast cancer risk. The relative risk (RR) of breast cancer after 12 or more years of OC use was 2.2 (1.2-4.0). OC use for more than 7 years before first full-term pregnancy entailed an increased breast cancer risk (RR = 2.0 [1.0-4.2]) which was of borderline significance. When total duration of use was considered, the risk of breast cancer was virtually unrelated to age at first OC use and latency from first use. The results suggest that long-term use of OCs may increase the risk of breast cancer in young women. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2876135/Oral_contraceptive_use_and_breast_cancer_in_young_women__A_joint_national_case_control_study_in_Sweden_and_Norway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(86)90166-2 DB - PRIME DP - Unbound Medicine ER -