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Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs.
Antioxid Redox Signal 2018; 29(9):864-879AR

Abstract

SIGNIFICANCE

Mesenchymal stem cells (MSCs), adult stem cells with the potential of differentiation into mesodermal lineages, play an important role in tissue homeostasis and regeneration. In different organs, a subpopulation of MSCs is located near the vasculature and possibly represents the original source of lineage-committed mesenchymal progenitors. Recent Advances: The plasticity and immune characteristics of MSCs render them a preferential tool for regenerative cell therapy.

CRITICAL ISSUES

The culture expansion needed before MSC transplantation is associated with cellular senescence. Moreover, accelerated senescence of the total and perivascular MSC pool has been observed in humans and mouse models of premature aging disorders. MSC dysfunction is acknowledged as a culprit for the aging-associated degeneration of mesodermal tissues, but the underlying epigenetic pathways remain elusive. This article reviews current understanding of mechanisms impinging on MSC health, including oxidative stress, Nrf2-antioxidant responsive element activity, sirtuins, noncoding RNAs, and PKCs.

FUTURE DIRECTIONS

We provide evidence that epigenetic profiling of MSCs is utilitarian to the prediction of therapeutic outcomes. In addition, strategies that target oxidative stress-associated mechanisms represent promising approaches to counteract the detrimental effect of age and senescence in MSCs.-Antioxid. Redox Signal. 29, 864-879.

Authors+Show Affiliations

1 Laboratory of Cardiovascular Research , IRCCS MultiMedica, Milan, Italy .2 School of Clinical Sciences, Bristol Heart Institute, University of Bristol , United Kingdom .1 Laboratory of Cardiovascular Research , IRCCS MultiMedica, Milan, Italy .2 School of Clinical Sciences, Bristol Heart Institute, University of Bristol , United Kingdom .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28762752

Citation

Vono, Rosa, et al. "Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation By Coding and Noncoding RNAs." Antioxidants & Redox Signaling, vol. 29, no. 9, 2018, pp. 864-879.
Vono R, Jover Garcia E, Spinetti G, et al. Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs. Antioxid Redox Signal. 2018;29(9):864-879.
Vono, R., Jover Garcia, E., Spinetti, G., & Madeddu, P. (2018). Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs. Antioxidants & Redox Signaling, 29(9), pp. 864-879. doi:10.1089/ars.2017.7294.
Vono R, et al. Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation By Coding and Noncoding RNAs. Antioxid Redox Signal. 2018 09 20;29(9):864-879. PubMed PMID: 28762752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs. AU - Vono,Rosa, AU - Jover Garcia,Eva, AU - Spinetti,Gaia, AU - Madeddu,Paolo, Y1 - 2017/09/11/ PY - 2017/8/2/pubmed PY - 2017/8/2/medline PY - 2017/8/2/entrez KW - cell therapy KW - mesenchymal stem cells KW - pericytes KW - reactive oxygen species KW - senescence SP - 864 EP - 879 JF - Antioxidants & redox signaling JO - Antioxid. Redox Signal. VL - 29 IS - 9 N2 - SIGNIFICANCE: Mesenchymal stem cells (MSCs), adult stem cells with the potential of differentiation into mesodermal lineages, play an important role in tissue homeostasis and regeneration. In different organs, a subpopulation of MSCs is located near the vasculature and possibly represents the original source of lineage-committed mesenchymal progenitors. Recent Advances: The plasticity and immune characteristics of MSCs render them a preferential tool for regenerative cell therapy. CRITICAL ISSUES: The culture expansion needed before MSC transplantation is associated with cellular senescence. Moreover, accelerated senescence of the total and perivascular MSC pool has been observed in humans and mouse models of premature aging disorders. MSC dysfunction is acknowledged as a culprit for the aging-associated degeneration of mesodermal tissues, but the underlying epigenetic pathways remain elusive. This article reviews current understanding of mechanisms impinging on MSC health, including oxidative stress, Nrf2-antioxidant responsive element activity, sirtuins, noncoding RNAs, and PKCs. FUTURE DIRECTIONS: We provide evidence that epigenetic profiling of MSCs is utilitarian to the prediction of therapeutic outcomes. In addition, strategies that target oxidative stress-associated mechanisms represent promising approaches to counteract the detrimental effect of age and senescence in MSCs.-Antioxid. Redox Signal. 29, 864-879. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/28762752/Oxidative_Stress_in_Mesenchymal_Stem_Cell_Senescence:_Regulation_by_Coding_and_Noncoding_RNAs_ L2 - https://www.liebertpub.com/doi/full/10.1089/ars.2017.7294?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -