TY - JOUR T1 - Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study. AU - Qin,Bo, AU - Xun,Pengcheng, AU - Jacobs,David R,Jr AU - Zhu,Na, AU - Daviglus,Martha L, AU - Reis,Jared P, AU - Steffen,Lyn M, AU - Van Horn,Linda, AU - Sidney,Stephen, AU - He,Ka, Y1 - 2017/08/02/ PY - 2017/03/28/received PY - 2017/07/10/accepted PY - 2017/8/5/pubmed PY - 2017/10/14/medline PY - 2017/8/4/entrez KW - cognitive function KW - epidemiology KW - folate KW - middle age KW - niacin KW - vitamin B-12 KW - vitamin B-6 SP - 1032 EP - 1040 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 106 IS - 4 N2 - Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.Objective: We hypothesize that higher intake of these B vitamins in young adulthood is associated with better cognition later in life.Design: This study comprised a community-based multicenter cohort of black and white men and women aged 18-30 y in 1985-1986 (year 0, i.e., baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3136). We examined participants' CARDIA diet history at years 0, 7, and 20 to assess nutrient intake, including dietary and supplemental B vitamins. We measured cognitive function at year 25 (mean ± SD age: 50 ± 4 y) through the use of the Rey Auditory Verbal Learning Test (RAVLT) for verbal memory, the Digit Symbol Substitution Test (DSST) for psychomotor speed, and a modified Stroop interference test for executive function. Higher RAVLT and DSST scores and a lower Stroop score indicated better cognitive function. We used multivariable-adjusted linear regressions to estimate mean differences in cognitive scores and 95% CIs.Results: Comparing the highest quintile with the lowest (quintile 5 compared with quintile 1), cumulative total intake of niacin was significantly associated with 3.92 more digits on the DSST (95% CI: 2.28, 5.55; P-trend < 0.01) and 1.89 points lower interference score on the Stroop test (95% CI: -3.10, -0.68; P-trend = 0.05). Total folate was associated with 2.56 more digits on the DSST (95% CI: 0.82, 4.31; P-trend = 0.01). We also found that higher intakes of vitamin B-6 (quartile 5 compared with quartile 1: 2.62; 95% CI: 0.97, 4.28; P-trend = 0.02) and vitamin B-12 (quartile 5 compared with quartile 1: 2.08; 95% CI: 0.52, 3.65; P-trend = 0.02) resulted in better psychomotor speed measured by DSST scores.Conclusion: Higher intake of B vitamins throughout young adulthood was associated with better cognitive function in midlife. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28768650/Intake_of_niacin_folate_vitamin_B_6_and_vitamin_B_12_through_young_adulthood_and_cognitive_function_in_midlife:_the_Coronary_Artery_Risk_Development_in_Young_Adults__CARDIA__study_ DB - PRIME DP - Unbound Medicine ER -