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Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes.

Abstract

Background:

Nut consumption has been associated with decreased risk of colorectal, endometrial, lung, and pancreatic cancers. Polyphenols, fiber, vitamins, and minerals in nuts may confer this observed protective effect. To our knowledge, no prospective study has evaluated the effect of nut consumption on esophageal and gastric cancers.

Objective:

The objective was to evaluate the associations between nut and peanut butter consumption and the risk of esophageal and gastric cancers and their different subtypes.

Design:

In this study we used data from the NIH-AARP Diet and Health Study, which enrolled 566,407 persons who were 50-71 y old at baseline (1995-1996). The median follow-up time was 15.5 y. Intakes of nuts and peanut butter were assessed through the use of a validated food-frequency questionnaire. We used Cox proportional hazard models to estimate HRs and 95% CIs for esophageal and gastric cancers and their subtypes.

Results:

We identified 966 incident cases of esophageal adenocarcinomas, 323 cases of esophageal squamous cell carcinoma, 698 cases of gastric cardia adenocarcinoma, and 732 cases of gastric noncardia adenocarcinoma. Compared with those who did not consume nuts or peanut butter [lowest category of consumption (C0)], participants in the highest category of nut consumption (C3) had a lower risk of developing gastric noncardia adenocarcinoma [C3 compared with C0, HR: 0.73 (95% CI: 0.57, 0.94)]. This inverse association was also seen for peanut butter consumption [C3 compared with C0, HR: 0.75 (95% CI: 0.60, 0.94)]. We observed no significant associations between the highest and lowest intakes of nuts or peanut butter and the risk of gastric cardia adenocarcinoma, esophageal adenocarcinoma, or esophageal squamous cell carcinoma.

Conclusions:

Among older American adults, both nut and peanut butter consumption were inversely associated with the risk of gastric noncardia adenocarcinoma. This trial was registered at clinicaltrials.gov as NCT00340015.

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  • Authors+Show Affiliations

    ,

    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD. Departments of Nutrition and Biochemistry, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran; and. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

    ,

    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

    ,

    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

    ,

    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

    ,

    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

    Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; abnetc@mail.nih.gov.

    Source

    MeSH

    Adenocarcinoma
    Aged
    Arachis
    Carcinoma, Squamous Cell
    Diet
    Diet Surveys
    Esophageal Neoplasms
    Esophageal Squamous Cell Carcinoma
    Feeding Behavior
    Female
    Humans
    Male
    Middle Aged
    Nuts
    Proportional Hazards Models
    Prospective Studies
    Stomach Neoplasms

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28768652

    Citation

    Hashemian, Maryam, et al. "Nut and Peanut Butter Consumption and the Risk of Esophageal and Gastric Cancer Subtypes." The American Journal of Clinical Nutrition, vol. 106, no. 3, 2017, pp. 858-864.
    Hashemian M, Murphy G, Etemadi A, et al. Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes. Am J Clin Nutr. 2017;106(3):858-864.
    Hashemian, M., Murphy, G., Etemadi, A., Dawsey, S. M., Liao, L. M., & Abnet, C. C. (2017). Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes. The American Journal of Clinical Nutrition, 106(3), pp. 858-864. doi:10.3945/ajcn.117.159467.
    Hashemian M, et al. Nut and Peanut Butter Consumption and the Risk of Esophageal and Gastric Cancer Subtypes. Am J Clin Nutr. 2017;106(3):858-864. PubMed PMID: 28768652.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes. AU - Hashemian,Maryam, AU - Murphy,Gwen, AU - Etemadi,Arash, AU - Dawsey,Sanford M, AU - Liao,Linda M, AU - Abnet,Christian C, Y1 - 2017/08/02/ PY - 2017/04/28/received PY - 2017/06/29/accepted PY - 2017/8/5/pubmed PY - 2017/9/14/medline PY - 2017/8/4/entrez KW - Mediterranean diet KW - adenocarcinoma KW - esophageal cancer KW - gastric cancer KW - nut KW - peanut butter KW - prevention KW - squamous cell carcinoma SP - 858 EP - 864 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 106 IS - 3 N2 - Background: Nut consumption has been associated with decreased risk of colorectal, endometrial, lung, and pancreatic cancers. Polyphenols, fiber, vitamins, and minerals in nuts may confer this observed protective effect. To our knowledge, no prospective study has evaluated the effect of nut consumption on esophageal and gastric cancers.Objective: The objective was to evaluate the associations between nut and peanut butter consumption and the risk of esophageal and gastric cancers and their different subtypes.Design: In this study we used data from the NIH-AARP Diet and Health Study, which enrolled 566,407 persons who were 50-71 y old at baseline (1995-1996). The median follow-up time was 15.5 y. Intakes of nuts and peanut butter were assessed through the use of a validated food-frequency questionnaire. We used Cox proportional hazard models to estimate HRs and 95% CIs for esophageal and gastric cancers and their subtypes.Results: We identified 966 incident cases of esophageal adenocarcinomas, 323 cases of esophageal squamous cell carcinoma, 698 cases of gastric cardia adenocarcinoma, and 732 cases of gastric noncardia adenocarcinoma. Compared with those who did not consume nuts or peanut butter [lowest category of consumption (C0)], participants in the highest category of nut consumption (C3) had a lower risk of developing gastric noncardia adenocarcinoma [C3 compared with C0, HR: 0.73 (95% CI: 0.57, 0.94)]. This inverse association was also seen for peanut butter consumption [C3 compared with C0, HR: 0.75 (95% CI: 0.60, 0.94)]. We observed no significant associations between the highest and lowest intakes of nuts or peanut butter and the risk of gastric cardia adenocarcinoma, esophageal adenocarcinoma, or esophageal squamous cell carcinoma.Conclusions: Among older American adults, both nut and peanut butter consumption were inversely associated with the risk of gastric noncardia adenocarcinoma. This trial was registered at clinicaltrials.gov as NCT00340015. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28768652/Nut_and_peanut_butter_consumption_and_the_risk_of_esophageal_and_gastric_cancer_subtypes_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.117.159467 DB - PRIME DP - Unbound Medicine ER -