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Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases.
Endocr J 2017; 64(10):955-961EJ

Abstract

It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's thyroiditis. However, limited data are available on the comparison of TgAb and TPOAb prevalence as a diagnostic measurement for Hashimoto's thyroiditis using sensitive immunoassays. We herein used five different current immunoassay kits (A-E) to compare the prevalence of TgAb and TPOAb in Hashimoto's thyroiditis (n = 70), Graves' disease (n = 70), painless thyroiditis (n = 50), and healthy control subjects (n = 100). In patients with Hashimoto's thyroiditis, positive TgAb was significantly more frequent than positive TPOAb in kits A-D (mean ± SD of the four kits: 98.6 ± 1.7 vs 81.4 ± 2.0%). In patients with Graves' disease, TgAb prevalence was almost equivalent to that of TPOAb in five kits. Patients with painless thyroiditis exhibited positive TgAb significantly more frequently than positive TPOAb in kits A-D (73.5 ± 4.1 vs 33.0 ± 3.4%). The prevalence of TgAb alone was significantly higher than that of TPOAb alone in both Hashimoto's thyroiditis and painless thyroiditis in kits A-D. In kit E, TgAb and TPOAb prevalence did not differ significantly for any disease, and TgAb distribution was different from other kits. In conclusion, the prevalence of TgAb was higher than that of TPOAb in patients with Hashimoto's thyroiditis and painless thyroiditis using commercially available kits. We suggest that TgAb immunoassay is the first choice of screening test for thyroid autoimmune abnormalities in Japan.

Authors+Show Affiliations

Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28768936

Citation

Nishihara, Eijun, et al. "Comparison of Thyroglobulin and Thyroid Peroxidase Antibodies Measured By Five Different Kits in Autoimmune Thyroid Diseases." Endocrine Journal, vol. 64, no. 10, 2017, pp. 955-961.
Nishihara E, Amino N, Kudo T, et al. Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases. Endocr J. 2017;64(10):955-961.
Nishihara, E., Amino, N., Kudo, T., Ito, M., Fukata, S., Nishikawa, M., ... Miyauchi, A. (2017). Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases. Endocrine Journal, 64(10), pp. 955-961. doi:10.1507/endocrj.EJ17-0164.
Nishihara E, et al. Comparison of Thyroglobulin and Thyroid Peroxidase Antibodies Measured By Five Different Kits in Autoimmune Thyroid Diseases. Endocr J. 2017 Oct 28;64(10):955-961. PubMed PMID: 28768936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases. AU - Nishihara,Eijun, AU - Amino,Nobuyuki, AU - Kudo,Takumi, AU - Ito,Mitsuru, AU - Fukata,Shuji, AU - Nishikawa,Mitsushige, AU - Nakamura,Hirotoshi, AU - Miyauchi,Akira, Y1 - 2017/08/02/ PY - 2017/8/5/pubmed PY - 2018/7/11/medline PY - 2017/8/4/entrez KW - Hashimoto’s thyroiditis KW - Thyroglobulin antibodies KW - Thyroid peroxidase antibodies SP - 955 EP - 961 JF - Endocrine journal JO - Endocr. J. VL - 64 IS - 10 N2 - It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's thyroiditis. However, limited data are available on the comparison of TgAb and TPOAb prevalence as a diagnostic measurement for Hashimoto's thyroiditis using sensitive immunoassays. We herein used five different current immunoassay kits (A-E) to compare the prevalence of TgAb and TPOAb in Hashimoto's thyroiditis (n = 70), Graves' disease (n = 70), painless thyroiditis (n = 50), and healthy control subjects (n = 100). In patients with Hashimoto's thyroiditis, positive TgAb was significantly more frequent than positive TPOAb in kits A-D (mean ± SD of the four kits: 98.6 ± 1.7 vs 81.4 ± 2.0%). In patients with Graves' disease, TgAb prevalence was almost equivalent to that of TPOAb in five kits. Patients with painless thyroiditis exhibited positive TgAb significantly more frequently than positive TPOAb in kits A-D (73.5 ± 4.1 vs 33.0 ± 3.4%). The prevalence of TgAb alone was significantly higher than that of TPOAb alone in both Hashimoto's thyroiditis and painless thyroiditis in kits A-D. In kit E, TgAb and TPOAb prevalence did not differ significantly for any disease, and TgAb distribution was different from other kits. In conclusion, the prevalence of TgAb was higher than that of TPOAb in patients with Hashimoto's thyroiditis and painless thyroiditis using commercially available kits. We suggest that TgAb immunoassay is the first choice of screening test for thyroid autoimmune abnormalities in Japan. SN - 1348-4540 UR - https://www.unboundmedicine.com/medline/citation/28768936/Comparison_of_thyroglobulin_and_thyroid_peroxidase_antibodies_measured_by_five_different_kits_in_autoimmune_thyroid_diseases_ L2 - https://dx.doi.org/10.1507/endocrj.EJ17-0164 DB - PRIME DP - Unbound Medicine ER -