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Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: Dendritic degeneration of retinal ganglion cell.
PLoS One. 2017; 12(8):e0182404.Plos

Abstract

PURPOSE

To evaluate the changes of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and ganglion cell-inner plexiform layer (GCIPL) thicknesses and compare structure-function relationships of 4 retinal layers using spectral-domain optical coherence tomography (SD-OCT) in macular region of glaucoma patients.

METHODS

In cross-sectional study, a total of 85 eyes with pre-perimetric to advanced glaucoma and 26 normal controls were enrolled. The glaucomatous eyes were subdivided into three groups according to the severity of visual field defect: a preperimetric glaucoma group, an early glaucoma group, and a moderate to advanced glaucoma group. RNFL, GCL, IPL, and GCIPL thicknesses were measured at the level of the macula by the Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT with automated segmentation software. For functional evaluation, corresponding mean sensitivity (MS) values were measured using 24-2 standard automated perimetry (SAP).

RESULTS

RNFL, GCL, IPL, and GCIPL thicknesses were significantly different among 4 groups (P < .001). Macular structure losses were positively correlated with the MS values of the 24-2 SAP for RNFL, GCL, IPL, and GCIPL (R = 0.553, 0.636, 0.648 and 0.646, respectively, P < .001). In regression analysis, IPL and GCIPL thicknesses showed stronger association with the corresponding MS values of 24-2 SAP compared with RNFL and GCL thicknesses (R2 = 0.420, P < .001 for IPL; R2 = 0.417, P< .001 for GCIPL thickness).

CONCLUSIONS

Segmented IPL thickness was significantly associated with the degree of glaucoma. Segmental analysis of the inner retinal layer including the IPL in macular region may provide valuable information for evaluating glaucoma.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Seoul St. Mary's Hospital, Seoul, South Korea.Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Seoul St. Mary's Hospital, Seoul, South Korea.Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Seoul St. Mary's Hospital, Seoul, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28771565

Citation

Kim, Eun Kyoung, et al. "Segmented Inner Plexiform Layer Thickness as a Potential Biomarker to Evaluate Open-angle Glaucoma: Dendritic Degeneration of Retinal Ganglion Cell." PloS One, vol. 12, no. 8, 2017, pp. e0182404.
Kim EK, Park HL, Park CK. Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: Dendritic degeneration of retinal ganglion cell. PLoS One. 2017;12(8):e0182404.
Kim, E. K., Park, H. L., & Park, C. K. (2017). Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: Dendritic degeneration of retinal ganglion cell. PloS One, 12(8), e0182404. https://doi.org/10.1371/journal.pone.0182404
Kim EK, Park HL, Park CK. Segmented Inner Plexiform Layer Thickness as a Potential Biomarker to Evaluate Open-angle Glaucoma: Dendritic Degeneration of Retinal Ganglion Cell. PLoS One. 2017;12(8):e0182404. PubMed PMID: 28771565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: Dendritic degeneration of retinal ganglion cell. AU - Kim,Eun Kyoung, AU - Park,Hae-Young Lopilly, AU - Park,Chan Kee, Y1 - 2017/08/03/ PY - 2017/03/21/received PY - 2017/07/16/accepted PY - 2017/8/4/entrez PY - 2017/8/5/pubmed PY - 2017/10/7/medline SP - e0182404 EP - e0182404 JF - PloS one JO - PLoS One VL - 12 IS - 8 N2 - PURPOSE: To evaluate the changes of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and ganglion cell-inner plexiform layer (GCIPL) thicknesses and compare structure-function relationships of 4 retinal layers using spectral-domain optical coherence tomography (SD-OCT) in macular region of glaucoma patients. METHODS: In cross-sectional study, a total of 85 eyes with pre-perimetric to advanced glaucoma and 26 normal controls were enrolled. The glaucomatous eyes were subdivided into three groups according to the severity of visual field defect: a preperimetric glaucoma group, an early glaucoma group, and a moderate to advanced glaucoma group. RNFL, GCL, IPL, and GCIPL thicknesses were measured at the level of the macula by the Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT with automated segmentation software. For functional evaluation, corresponding mean sensitivity (MS) values were measured using 24-2 standard automated perimetry (SAP). RESULTS: RNFL, GCL, IPL, and GCIPL thicknesses were significantly different among 4 groups (P < .001). Macular structure losses were positively correlated with the MS values of the 24-2 SAP for RNFL, GCL, IPL, and GCIPL (R = 0.553, 0.636, 0.648 and 0.646, respectively, P < .001). In regression analysis, IPL and GCIPL thicknesses showed stronger association with the corresponding MS values of 24-2 SAP compared with RNFL and GCL thicknesses (R2 = 0.420, P < .001 for IPL; R2 = 0.417, P< .001 for GCIPL thickness). CONCLUSIONS: Segmented IPL thickness was significantly associated with the degree of glaucoma. Segmental analysis of the inner retinal layer including the IPL in macular region may provide valuable information for evaluating glaucoma. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28771565/Segmented_inner_plexiform_layer_thickness_as_a_potential_biomarker_to_evaluate_open_angle_glaucoma:_Dendritic_degeneration_of_retinal_ganglion_cell_ L2 - https://dx.plos.org/10.1371/journal.pone.0182404 DB - PRIME DP - Unbound Medicine ER -