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Highlights of drug - and herb- induced liver injury in the literature from 2016: how best to translate new information into clinical practice?
Expert Opin Drug Metab Toxicol 2017; 13(9):935-951EO

Abstract

INTRODUCTION

Over 1500 papers on drug-induced liver injury (DILI) and herb-induced liver injury (HILI) were published in 2016, many of which have the potential to impact clinical practice. Areas covered: Clinical studies and case series that lent themselves to new concepts in diagnosing, and treating DILI were selected for inclusion. Epidemiology of DILI in large prospective registries was highlighted. Causality assessment of drug hepatotoxicity remains challenging, as seen with cases of OxyELITE Pro (OEP). In 2016 updates to the Roussel Uclaf Causality Assessment Method (RUCAM) were published to aid in the accuracy of diagnosing DILI/HILI. New reports of established hepatotoxins were again discussed in 2016, including genetic risk factors for DILI with respect to antituberculous agents. Expert opinion: 2016 marked a turning point in how much credence should be placed in the current causality assessment for DILI/HILI cases. Many recognized hepatotoxins are backed by a relatively few number of literature reports. Danan and Teschke make a strong case that an updated RUCAM should remain the gold standard for diagnosing DILI/HILI going forward, although the role of expert opinion is often still needed in cases where RUCAM falls short. The field of chemoinformatics continues to evolve while we await a truly predictive and diagnostic DILI biomarker.

Authors+Show Affiliations

a Department of Medicine, Division of Gastroenterology, Hepatology Section , Georgetown University Hospital , Washington , DC , USA.a Department of Medicine, Division of Gastroenterology, Hepatology Section , Georgetown University Hospital , Washington , DC , USA.a Department of Medicine, Division of Gastroenterology, Hepatology Section , Georgetown University Hospital , Washington , DC , USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28772086

Citation

Shahbaz, Omar, et al. "Highlights of Drug - and Herb- Induced Liver Injury in the Literature From 2016: How Best to Translate New Information Into Clinical Practice?" Expert Opinion On Drug Metabolism & Toxicology, vol. 13, no. 9, 2017, pp. 935-951.
Shahbaz O, Mahajan S, Lewis JH. Highlights of drug - and herb- induced liver injury in the literature from 2016: how best to translate new information into clinical practice? Expert Opin Drug Metab Toxicol. 2017;13(9):935-951.
Shahbaz, O., Mahajan, S., & Lewis, J. H. (2017). Highlights of drug - and herb- induced liver injury in the literature from 2016: how best to translate new information into clinical practice? Expert Opinion On Drug Metabolism & Toxicology, 13(9), pp. 935-951. doi:10.1080/17425255.2017.1362391.
Shahbaz O, Mahajan S, Lewis JH. Highlights of Drug - and Herb- Induced Liver Injury in the Literature From 2016: How Best to Translate New Information Into Clinical Practice. Expert Opin Drug Metab Toxicol. 2017;13(9):935-951. PubMed PMID: 28772086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highlights of drug - and herb- induced liver injury in the literature from 2016: how best to translate new information into clinical practice? AU - Shahbaz,Omar, AU - Mahajan,Sandeep, AU - Lewis,James H, PY - 2017/8/5/pubmed PY - 2017/9/25/medline PY - 2017/8/4/entrez KW - DILI KW - drug-induced liver injury KW - hepatotoxicity KW - hepatotoxins SP - 935 EP - 951 JF - Expert opinion on drug metabolism & toxicology JO - Expert Opin Drug Metab Toxicol VL - 13 IS - 9 N2 - INTRODUCTION: Over 1500 papers on drug-induced liver injury (DILI) and herb-induced liver injury (HILI) were published in 2016, many of which have the potential to impact clinical practice. Areas covered: Clinical studies and case series that lent themselves to new concepts in diagnosing, and treating DILI were selected for inclusion. Epidemiology of DILI in large prospective registries was highlighted. Causality assessment of drug hepatotoxicity remains challenging, as seen with cases of OxyELITE Pro (OEP). In 2016 updates to the Roussel Uclaf Causality Assessment Method (RUCAM) were published to aid in the accuracy of diagnosing DILI/HILI. New reports of established hepatotoxins were again discussed in 2016, including genetic risk factors for DILI with respect to antituberculous agents. Expert opinion: 2016 marked a turning point in how much credence should be placed in the current causality assessment for DILI/HILI cases. Many recognized hepatotoxins are backed by a relatively few number of literature reports. Danan and Teschke make a strong case that an updated RUCAM should remain the gold standard for diagnosing DILI/HILI going forward, although the role of expert opinion is often still needed in cases where RUCAM falls short. The field of chemoinformatics continues to evolve while we await a truly predictive and diagnostic DILI biomarker. SN - 1744-7607 UR - https://www.unboundmedicine.com/medline/citation/28772086/Highlights_of_drug___and_herb__induced_liver_injury_in_the_literature_from_2016:_how_best_to_translate_new_information_into_clinical_practice L2 - http://www.tandfonline.com/doi/full/10.1080/17425255.2017.1362391 DB - PRIME DP - Unbound Medicine ER -