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Prevention of graft failure by an anti-HLFA-1 monoclonal antibody in HLA-mismatched bone-marrow transplantation.
Lancet. 1986 Nov 08; 2(8515):1058-61.Lct

Abstract

Seven patients with immunodeficiencies (Wiskott-Aldrich syndrome, combined immunodeficiency, and osteopetrosis) were given a mouse monoclonal antibody against the alpha subunit of human leucocyte functional antigen (HLFA-1; CD18) to facilitate the engraftment of mismatched haploidentical related-donor bone marrow. Other conditioning included busulphan, cyclophosphamide, and antilymphocyte globulin. To prevent graft-versus-host disease the bone-marrow T cells were depleted with sheep erythrocyte rosetting and cyclosporin therapy was given. HLFA-1 antibody injections were well tolerated without side-effects except slight, transient fever (38-40 degrees) after the first injection. Engraftment was rapid in all seven patients. The regenerating leucocytes were of donor origin in all cases, and two patients have a mixed chimera. Two patients died from infections. The others are alive and well 60-395 days after transplantation. In a historical control group given the same treatment without anti-HLFA-1 infusion, only one of seven transplants partially engrafted; only two patients remain alive with autologous reconstitution but with uncorrected immunodeficiency.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2877223

Citation

Fischer, A, et al. "Prevention of Graft Failure By an anti-HLFA-1 Monoclonal Antibody in HLA-mismatched Bone-marrow Transplantation." Lancet (London, England), vol. 2, no. 8515, 1986, pp. 1058-61.
Fischer A, Griscelli C, Blanche S, et al. Prevention of graft failure by an anti-HLFA-1 monoclonal antibody in HLA-mismatched bone-marrow transplantation. Lancet. 1986;2(8515):1058-61.
Fischer, A., Griscelli, C., Blanche, S., Le Deist, F., Veber, F., Lopez, M., Delaage, M., Olive, D., Mawas, C., & Janossy, G. (1986). Prevention of graft failure by an anti-HLFA-1 monoclonal antibody in HLA-mismatched bone-marrow transplantation. Lancet (London, England), 2(8515), 1058-61.
Fischer A, et al. Prevention of Graft Failure By an anti-HLFA-1 Monoclonal Antibody in HLA-mismatched Bone-marrow Transplantation. Lancet. 1986 Nov 8;2(8515):1058-61. PubMed PMID: 2877223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of graft failure by an anti-HLFA-1 monoclonal antibody in HLA-mismatched bone-marrow transplantation. AU - Fischer,A, AU - Griscelli,C, AU - Blanche,S, AU - Le Deist,F, AU - Veber,F, AU - Lopez,M, AU - Delaage,M, AU - Olive,D, AU - Mawas,C, AU - Janossy,G, PY - 1986/11/8/pubmed PY - 1986/11/8/medline PY - 1986/11/8/entrez SP - 1058 EP - 61 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8515 N2 - Seven patients with immunodeficiencies (Wiskott-Aldrich syndrome, combined immunodeficiency, and osteopetrosis) were given a mouse monoclonal antibody against the alpha subunit of human leucocyte functional antigen (HLFA-1; CD18) to facilitate the engraftment of mismatched haploidentical related-donor bone marrow. Other conditioning included busulphan, cyclophosphamide, and antilymphocyte globulin. To prevent graft-versus-host disease the bone-marrow T cells were depleted with sheep erythrocyte rosetting and cyclosporin therapy was given. HLFA-1 antibody injections were well tolerated without side-effects except slight, transient fever (38-40 degrees) after the first injection. Engraftment was rapid in all seven patients. The regenerating leucocytes were of donor origin in all cases, and two patients have a mixed chimera. Two patients died from infections. The others are alive and well 60-395 days after transplantation. In a historical control group given the same treatment without anti-HLFA-1 infusion, only one of seven transplants partially engrafted; only two patients remain alive with autologous reconstitution but with uncorrected immunodeficiency. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2877223/Prevention_of_graft_failure_by_an_anti_HLFA_1_monoclonal_antibody_in_HLA_mismatched_bone_marrow_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(86)90465-4 DB - PRIME DP - Unbound Medicine ER -