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Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.
Lancet. 1986 Nov 08; 2(8515):1066-7.Lct

Abstract

Lathyrism, a form of motoneuron disease induced by excessive consumption of th legume Lathyrus sativus (chickling pea), presents as signs of pyramidal tract involvement. Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume. BOAA, a potent agonist of the excitatory neurotransmitter glutamate, is likely to be causally associated with lathyrism in man.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2877226

Citation

Spencer, P S., et al. "Lathyrism: Evidence for Role of the Neuroexcitatory Aminoacid BOAA." Lancet (London, England), vol. 2, no. 8515, 1986, pp. 1066-7.
Spencer PS, Roy DN, Ludolph A, et al. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet. 1986;2(8515):1066-7.
Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., & Schaumburg, H. H. (1986). Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet (London, England), 2(8515), 1066-7.
Spencer PS, et al. Lathyrism: Evidence for Role of the Neuroexcitatory Aminoacid BOAA. Lancet. 1986 Nov 8;2(8515):1066-7. PubMed PMID: 2877226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. AU - Spencer,P S, AU - Roy,D N, AU - Ludolph,A, AU - Hugon,J, AU - Dwivedi,M P, AU - Schaumburg,H H, PY - 1986/11/8/pubmed PY - 1986/11/8/medline PY - 1986/11/8/entrez SP - 1066 EP - 7 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8515 N2 - Lathyrism, a form of motoneuron disease induced by excessive consumption of th legume Lathyrus sativus (chickling pea), presents as signs of pyramidal tract involvement. Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume. BOAA, a potent agonist of the excitatory neurotransmitter glutamate, is likely to be causally associated with lathyrism in man. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2877226/Lathyrism:_evidence_for_role_of_the_neuroexcitatory_aminoacid_BOAA_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(86)90468-X DB - PRIME DP - Unbound Medicine ER -