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The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study.
Int J Obes (Lond). 2017 Dec; 41(12):1755-1760.IJ

Abstract

BACKGROUND

Vitamin D insufficiency (defined as <75 nmol l-1) is widespread among pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders, including asthma and eczema, are on the rise among children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood.

SUBJECTS AND METHODS

Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks' gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints cohort study. The offspring of 1208 mothers were followed up at age 5-6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedance) and history of asthma and eczema. Multivariable analysis controlled for maternal body mass index (BMI), age and sex of the child and season of serum sampling.

RESULTS

Complete data were available for 922 mother-child pairs. Each 10 nmol l-1 increase in maternal 25-hydroxyvitamin D concentration at 15 weeks' gestation was associated with a decrease in offspring PBF of 0.2% (95% confidence interval 0.04-0.36%, P=0.01) after adjustment for confounders but was not related to child BMI z-score. Maternal mean (±s.d.) 25-hydroxyvitamin D concentration was similar in children who did and did not have asthma (71.7±26.1 vs 73.3±27.1 nmol l-1, P=0.5), severe asthma (68.6±28.6 vs 73.3±26.8 nmol l-1, P=0.2) and eczema (71.9±27.0 vs 73.2±27.0 nmol l-1, P=0.5).

CONCLUSIONS

The finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials.

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Authors+Show Affiliations

Boyle VT
Gravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
Thorstensen EB
Gravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
Thompson JMD
The Department of Paediatrics, Child & Youth Health, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. The Department of Obstetrics and Gynaecology and South Auckland Clinical School, University of Auckland, Auckland, New Zealand.
McCowan LME
The Department of Obstetrics and Gynaecology and South Auckland Clinical School, University of Auckland, Auckland, New Zealand.
Mitchell EA
The Department of Paediatrics, Child & Youth Health, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Godfrey KM
MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Poston L
Division of Women's Health, King's College London, London, UK.
Wall CR
Department of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Murphy R
The School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Cutfield W
Gravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
Kenealy T
The School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Kenny LC
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland. Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland.
Baker PN
Gravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand. The College of Medicine, Biosciences and Psychology, University of Leicester, Leicester, UK.

MeSH

AdiposityAdultAsthmaChild, PreschoolEczemaFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleMaternal Nutritional Physiological PhenomenaMothersNutrition SurveysPediatric ObesityPregnancyProspective StudiesSurveys and QuestionnairesSwedenVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28775375

Citation

Boyle, V T., et al. "The Relationship Between Maternal 25-hydroxyvitamin D Status in Pregnancy and Childhood Adiposity and Allergy: an Observational Study." International Journal of Obesity (2005), vol. 41, no. 12, 2017, pp. 1755-1760.
Boyle VT, Thorstensen EB, Thompson JMD, et al. The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study. Int J Obes (Lond). 2017;41(12):1755-1760.
Boyle, V. T., Thorstensen, E. B., Thompson, J. M. D., McCowan, L. M. E., Mitchell, E. A., Godfrey, K. M., Poston, L., Wall, C. R., Murphy, R., Cutfield, W., Kenealy, T., Kenny, L. C., & Baker, P. N. (2017). The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study. International Journal of Obesity (2005), 41(12), 1755-1760. https://doi.org/10.1038/ijo.2017.182
Boyle VT, et al. The Relationship Between Maternal 25-hydroxyvitamin D Status in Pregnancy and Childhood Adiposity and Allergy: an Observational Study. Int J Obes (Lond). 2017;41(12):1755-1760. PubMed PMID: 28775375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study. AU - Boyle,V T, AU - Thorstensen,E B, AU - Thompson,J M D, AU - McCowan,L M E, AU - Mitchell,E A, AU - Godfrey,K M, AU - Poston,L, AU - Wall,C R, AU - Murphy,R, AU - Cutfield,W, AU - Kenealy,T, AU - Kenny,L C, AU - Baker,P N, Y1 - 2017/08/04/ PY - 2016/06/14/received PY - 2017/04/11/revised PY - 2017/05/16/accepted PY - 2017/8/5/pubmed PY - 2018/9/20/medline PY - 2017/8/5/entrez SP - 1755 EP - 1760 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 41 IS - 12 N2 - BACKGROUND: Vitamin D insufficiency (defined as <75 nmol l-1) is widespread among pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders, including asthma and eczema, are on the rise among children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood. SUBJECTS AND METHODS: Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks' gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints cohort study. The offspring of 1208 mothers were followed up at age 5-6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedance) and history of asthma and eczema. Multivariable analysis controlled for maternal body mass index (BMI), age and sex of the child and season of serum sampling. RESULTS: Complete data were available for 922 mother-child pairs. Each 10 nmol l-1 increase in maternal 25-hydroxyvitamin D concentration at 15 weeks' gestation was associated with a decrease in offspring PBF of 0.2% (95% confidence interval 0.04-0.36%, P=0.01) after adjustment for confounders but was not related to child BMI z-score. Maternal mean (±s.d.) 25-hydroxyvitamin D concentration was similar in children who did and did not have asthma (71.7±26.1 vs 73.3±27.1 nmol l-1, P=0.5), severe asthma (68.6±28.6 vs 73.3±26.8 nmol l-1, P=0.2) and eczema (71.9±27.0 vs 73.2±27.0 nmol l-1, P=0.5). CONCLUSIONS: The finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/28775375/The_relationship_between_maternal_25_hydroxyvitamin_D_status_in_pregnancy_and_childhood_adiposity_and_allergy:_an_observational_study_ L2 - https://doi.org/10.1038/ijo.2017.182 DB - PRIME DP - Unbound Medicine ER -