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B lymphocyte population and immunoglobulins in Indian kala-azar in response to chemotherapy.
Acta Trop. 1986 Sep; 43(3):237-44.AT

Abstract

The levels of immunoglobulin classes (IgG, IgM and IgA) along with B lymphocyte population size were estimated in 24 kala-azar (KA) patients and results were compared with those obtained from 30 controls. A marked increase in the level of IgG and to a lesser extent in that of IgM was noted in the sera of KA patients. But, no such difference could be noted in serum IgA level. Along with the increased levels of immunoglobulins the elevation of B lymphocyte population size was also observed. Follow-up studies during and after chemotherapy for the period of 8 months showed that clinical improvement in KA patients resulting from treatment had a positive correlation with the progressive decline in the B lymphocyte population and in the level of immunoglobulin though the latter, particularly IgG, took a longer time to return to normal.

Authors

Neogy AB
No affiliation info available
Nandy A
No affiliation info available
Dastidar BG
No affiliation info available
Chowdhury AB
No affiliation info available

MeSH

AdolescentAdultAntimony Sodium GluconateB-LymphocytesChildChild, PreschoolGluconatesHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunoglobulinsInfantLeishmaniasis, VisceralLeukocyte Count

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2877550

Citation

Neogy, A B., et al. "B Lymphocyte Population and Immunoglobulins in Indian Kala-azar in Response to Chemotherapy." Acta Tropica, vol. 43, no. 3, 1986, pp. 237-44.
Neogy AB, Nandy A, Dastidar BG, et al. B lymphocyte population and immunoglobulins in Indian kala-azar in response to chemotherapy. Acta Trop. 1986;43(3):237-44.
Neogy, A. B., Nandy, A., Dastidar, B. G., & Chowdhury, A. B. (1986). B lymphocyte population and immunoglobulins in Indian kala-azar in response to chemotherapy. Acta Tropica, 43(3), 237-44.
Neogy AB, et al. B Lymphocyte Population and Immunoglobulins in Indian Kala-azar in Response to Chemotherapy. Acta Trop. 1986;43(3):237-44. PubMed PMID: 2877550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B lymphocyte population and immunoglobulins in Indian kala-azar in response to chemotherapy. AU - Neogy,A B, AU - Nandy,A, AU - Dastidar,B G, AU - Chowdhury,A B, PY - 1986/9/1/pubmed PY - 1986/9/1/medline PY - 1986/9/1/entrez SP - 237 EP - 44 JF - Acta tropica JO - Acta Trop VL - 43 IS - 3 N2 - The levels of immunoglobulin classes (IgG, IgM and IgA) along with B lymphocyte population size were estimated in 24 kala-azar (KA) patients and results were compared with those obtained from 30 controls. A marked increase in the level of IgG and to a lesser extent in that of IgM was noted in the sera of KA patients. But, no such difference could be noted in serum IgA level. Along with the increased levels of immunoglobulins the elevation of B lymphocyte population size was also observed. Follow-up studies during and after chemotherapy for the period of 8 months showed that clinical improvement in KA patients resulting from treatment had a positive correlation with the progressive decline in the B lymphocyte population and in the level of immunoglobulin though the latter, particularly IgG, took a longer time to return to normal. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/2877550/B_lymphocyte_population_and_immunoglobulins_in_Indian_kala_azar_in_response_to_chemotherapy_ DB - PRIME DP - Unbound Medicine ER -