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Discriminative stimulus properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in pigeons.
Drug Alcohol Depend. 1986 Oct; 18(2):159-64.DA

Abstract

Pigeons trained to discriminate (+)-amphetamine (AMPH) from saline in a two-key food-maintained drug discrimination paradigm, were used to investigate the discriminative stimulus (DS) effects of two structural analogues of amphetamine, namely (+/-)-3,4-methylenedioxymethamphetamine (MDMA) and (+/-)-3,4-methylenedioxyamphetamine (MDA). After discrimination performance was stable (90% injection-appropriate responding), test sessions with various doses of AMPH were conducted and a dose-dependent relationship for AMPH-appropriate responding was obtained. Both MDMA (3.0 mg/kg) and MDA (3.0 or 5.6 mg/kg) substituted for AMPH; however, at these doses MDA produced a greater decrease in response rate compared to AMPH and MDMA. Furthermore, while MDMA and MDA were similar in potency in producing drug-appropriate responding, both were less potent than AMPH. These results indicate that MDMA and MDA have DS effects similar to AMPH in pigeons.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2877843

Citation

Evans, S M., and C E. Johanson. "Discriminative Stimulus Properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in Pigeons." Drug and Alcohol Dependence, vol. 18, no. 2, 1986, pp. 159-64.
Evans SM, Johanson CE. Discriminative stimulus properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in pigeons. Drug Alcohol Depend. 1986;18(2):159-64.
Evans, S. M., & Johanson, C. E. (1986). Discriminative stimulus properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in pigeons. Drug and Alcohol Dependence, 18(2), 159-64.
Evans SM, Johanson CE. Discriminative Stimulus Properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in Pigeons. Drug Alcohol Depend. 1986;18(2):159-64. PubMed PMID: 2877843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in pigeons. AU - Evans,S M, AU - Johanson,C E, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 159 EP - 64 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 18 IS - 2 N2 - Pigeons trained to discriminate (+)-amphetamine (AMPH) from saline in a two-key food-maintained drug discrimination paradigm, were used to investigate the discriminative stimulus (DS) effects of two structural analogues of amphetamine, namely (+/-)-3,4-methylenedioxymethamphetamine (MDMA) and (+/-)-3,4-methylenedioxyamphetamine (MDA). After discrimination performance was stable (90% injection-appropriate responding), test sessions with various doses of AMPH were conducted and a dose-dependent relationship for AMPH-appropriate responding was obtained. Both MDMA (3.0 mg/kg) and MDA (3.0 or 5.6 mg/kg) substituted for AMPH; however, at these doses MDA produced a greater decrease in response rate compared to AMPH and MDMA. Furthermore, while MDMA and MDA were similar in potency in producing drug-appropriate responding, both were less potent than AMPH. These results indicate that MDMA and MDA have DS effects similar to AMPH in pigeons. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/2877843/Discriminative_stimulus_properties_of__+/___34_methylenedioxymethamphetamine_and__+/___34_methylenedioxyamphetamine_in_pigeons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0376-8716(86)90048-7 DB - PRIME DP - Unbound Medicine ER -