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A novel technique for the visualization of tablet punch surfaces: Characterization of surface modification, wear and sticking.
Int J Pharm. 2017 Sep 15; 530(1-2):440-454.IJ

Abstract

The surface quality of tablets is strongly related to the surface quality of the tablet punch. Therefore, regular control of the punch surfaces is needed to determine the surface properties, the wear status and sticking tendency of the punches. The aim of the present study was to develop and evaluate a new technique to visualize and evaluate tablet punch surfaces using high-resolution impression molding combined with 3D surface analysis. Standardized 3D surface texture parameters were analyzed by principal component analysis (PCA) to characterized differently surface-modified punches, punches with different wear status and the sticking pattern on the punch surfaces. It could be shown that the presented technique was precise enough to differentiate between differently coated and texturized punches, to evaluate the abrasive wear status of the investigated punches, and to visualize and assess punch tip sticking behavior. In conclusion, this novel technique may serve as a valuable tool for systematic punch surface characterization, wear status check-up and optimization of the punch surface quality e.g. for improvement of the anti-sticking behavior.

Authors+Show Affiliations

Division of Pharmaceutical Technology, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany.Center of Natural History (CeNak), University of Hamburg, Martin-Luther-King-Platz 3, 20146 Hamburg, Germany.Division of Pharmaceutical Technology, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address: claudia.leopold@uni-hamburg.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28779987

Citation

Al-Karawi, Claudia, et al. "A Novel Technique for the Visualization of Tablet Punch Surfaces: Characterization of Surface Modification, Wear and Sticking." International Journal of Pharmaceutics, vol. 530, no. 1-2, 2017, pp. 440-454.
Al-Karawi C, Kaiser T, Leopold CS. A novel technique for the visualization of tablet punch surfaces: Characterization of surface modification, wear and sticking. Int J Pharm. 2017;530(1-2):440-454.
Al-Karawi, C., Kaiser, T., & Leopold, C. S. (2017). A novel technique for the visualization of tablet punch surfaces: Characterization of surface modification, wear and sticking. International Journal of Pharmaceutics, 530(1-2), 440-454. https://doi.org/10.1016/j.ijpharm.2017.08.006
Al-Karawi C, Kaiser T, Leopold CS. A Novel Technique for the Visualization of Tablet Punch Surfaces: Characterization of Surface Modification, Wear and Sticking. Int J Pharm. 2017 Sep 15;530(1-2):440-454. PubMed PMID: 28779987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel technique for the visualization of tablet punch surfaces: Characterization of surface modification, wear and sticking. AU - Al-Karawi,Claudia, AU - Kaiser,Thomas, AU - Leopold,Claudia S, Y1 - 2017/08/03/ PY - 2017/06/13/received PY - 2017/07/26/revised PY - 2017/08/01/accepted PY - 2017/8/7/pubmed PY - 2018/1/10/medline PY - 2017/8/7/entrez KW - Ibuprofen KW - Molding KW - PCA KW - Sticking KW - Surface texture KW - Tableting KW - Visualization SP - 440 EP - 454 JF - International journal of pharmaceutics JO - Int J Pharm VL - 530 IS - 1-2 N2 - The surface quality of tablets is strongly related to the surface quality of the tablet punch. Therefore, regular control of the punch surfaces is needed to determine the surface properties, the wear status and sticking tendency of the punches. The aim of the present study was to develop and evaluate a new technique to visualize and evaluate tablet punch surfaces using high-resolution impression molding combined with 3D surface analysis. Standardized 3D surface texture parameters were analyzed by principal component analysis (PCA) to characterized differently surface-modified punches, punches with different wear status and the sticking pattern on the punch surfaces. It could be shown that the presented technique was precise enough to differentiate between differently coated and texturized punches, to evaluate the abrasive wear status of the investigated punches, and to visualize and assess punch tip sticking behavior. In conclusion, this novel technique may serve as a valuable tool for systematic punch surface characterization, wear status check-up and optimization of the punch surface quality e.g. for improvement of the anti-sticking behavior. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/28779987/A_novel_technique_for_the_visualization_of_tablet_punch_surfaces:_Characterization_of_surface_modification_wear_and_sticking_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(17)30714-7 DB - PRIME DP - Unbound Medicine ER -