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The response of serum growth hormone levels to the long-acting somatostatin analog SMS 201-995 in acromegaly.
J Clin Endocrinol Metab. 1987 Jan; 64(1):37-42.JC

Abstract

SMS 201-995 (SMS) is a long-acting analog of somatostatin. We studied the effect of SMS (50-100 micrograms, sc, every 8 h) on serum GH in five patients with acromegaly. Serum GH decreased significantly in four of the five patients 4 h after SMS treatment. In two of the four patients, this reduction was not sustained for 7 h, but sustained reduction to normal GH concentrations did occur in the two patients who had basal serum GH levels below 15 ng/ml. In the two patients whose responses were not sustained for 7 h, a higher dose of SMS did not cause sustained reduction in GH. SMS was well tolerated, except for one episode of elevated serum aminotransferase levels. These results indicate that SMS-induced reductions in serum GH in patients with acromegaly are often not sustained despite SMS administration every 8 h and indicate that the insufficient duration of effect may limit its therapeutic efficacy.

Authors

Comi RJ
No affiliation info available
Gorden P
No affiliation info available

MeSH

AcromegalyAdultCircadian RhythmDose-Response Relationship, DrugFemaleGrowth HormoneHumansMaleMiddle AgedOctreotideSomatostatinTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2878009

Citation

Comi, R J., and P Gorden. "The Response of Serum Growth Hormone Levels to the Long-acting Somatostatin Analog SMS 201-995 in Acromegaly." The Journal of Clinical Endocrinology and Metabolism, vol. 64, no. 1, 1987, pp. 37-42.
Comi RJ, Gorden P. The response of serum growth hormone levels to the long-acting somatostatin analog SMS 201-995 in acromegaly. J Clin Endocrinol Metab. 1987;64(1):37-42.
Comi, R. J., & Gorden, P. (1987). The response of serum growth hormone levels to the long-acting somatostatin analog SMS 201-995 in acromegaly. The Journal of Clinical Endocrinology and Metabolism, 64(1), 37-42.
Comi RJ, Gorden P. The Response of Serum Growth Hormone Levels to the Long-acting Somatostatin Analog SMS 201-995 in Acromegaly. J Clin Endocrinol Metab. 1987;64(1):37-42. PubMed PMID: 2878009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The response of serum growth hormone levels to the long-acting somatostatin analog SMS 201-995 in acromegaly. AU - Comi,R J, AU - Gorden,P, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 37 EP - 42 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 64 IS - 1 N2 - SMS 201-995 (SMS) is a long-acting analog of somatostatin. We studied the effect of SMS (50-100 micrograms, sc, every 8 h) on serum GH in five patients with acromegaly. Serum GH decreased significantly in four of the five patients 4 h after SMS treatment. In two of the four patients, this reduction was not sustained for 7 h, but sustained reduction to normal GH concentrations did occur in the two patients who had basal serum GH levels below 15 ng/ml. In the two patients whose responses were not sustained for 7 h, a higher dose of SMS did not cause sustained reduction in GH. SMS was well tolerated, except for one episode of elevated serum aminotransferase levels. These results indicate that SMS-induced reductions in serum GH in patients with acromegaly are often not sustained despite SMS administration every 8 h and indicate that the insufficient duration of effect may limit its therapeutic efficacy. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2878009/The_response_of_serum_growth_hormone_levels_to_the_long_acting_somatostatin_analog_SMS_201_995_in_acromegaly_ DB - PRIME DP - Unbound Medicine ER -