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Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.
J Polym Sci A Polym Chem 2016; 54(20):3267-3278JP

Abstract

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with fatty acid chain length of C4, C8, and C18 (PGAB, PGAO, and PGAS, respectively) at different degrees of substitution were prepared. These modifications yield comb-like polymers that modulate the amphiphilic characteristics of PGA. This novel class of biocompatible polymers has been characterized through various techniques such as FT-IR, 1H NMR, surface, thermal analysis, and their ability to self-assemble into colloidal structures was evaluated by using DLS. The highly tunable properties of PGA reported herein demonstrate a biodegradable polymer platform, ideal for engineering solid dispersions, nanoemulsions, or nanoparticles for healthcare applications. © 2016 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3267-3278.

Authors+Show Affiliations

School of Pharmacy, University of Nottingham, University ParkNottinghamNG7 2RDUnited Kingdom.Department of Pharmacy, Faculty of PharmacyMahidol UniversityBangkok10400Thailand.School of Chemical EngineeringUniversity of QueenslandSt LuciaQLD4067Australia.School of Pharmacy, University of Nottingham, University ParkNottinghamNG7 2RDUnited Kingdom.School of Pharmacy, University of Nottingham, University ParkNottinghamNG7 2RDUnited Kingdom.School of Pharmacy, University of Nottingham, University ParkNottinghamNG7 2RDUnited Kingdom.AstraZeneca, MacclesfieldSK102NAUnited Kingdom.AstraZeneca, MacclesfieldSK102NAUnited Kingdom.School of Pharmacy, University of Nottingham, University ParkNottinghamNG7 2RDUnited Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28781423

Citation

Taresco, Vincenzo, et al. "Properties of Acyl Modified Poly(glycerol-adipate) Comb-like Polymers and Their Self-assembly Into Nanoparticles." Journal of Polymer Science. Part A, Polymer Chemistry, vol. 54, no. 20, 2016, pp. 3267-3278.
Taresco V, Suksiriworapong J, Creasey R, et al. Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles. J Polym Sci A Polym Chem. 2016;54(20):3267-3278.
Taresco, V., Suksiriworapong, J., Creasey, R., Burley, J. C., Mantovani, G., Alexander, C., ... Garnett, M. C. (2016). Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles. Journal of Polymer Science. Part A, Polymer Chemistry, 54(20), pp. 3267-3278. doi:10.1002/pola.28215.
Taresco V, et al. Properties of Acyl Modified Poly(glycerol-adipate) Comb-like Polymers and Their Self-assembly Into Nanoparticles. J Polym Sci A Polym Chem. 2016 Oct 15;54(20):3267-3278. PubMed PMID: 28781423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles. AU - Taresco,Vincenzo, AU - Suksiriworapong,Jiraphong, AU - Creasey,Rhiannon, AU - Burley,Jonathan C, AU - Mantovani,Giuseppe, AU - Alexander,Cameron, AU - Treacher,Kevin, AU - Booth,Jonathan, AU - Garnett,Martin C, Y1 - 2016/07/08/ PY - 2016/04/20/received PY - 2016/06/15/accepted PY - 2017/8/8/entrez PY - 2017/8/7/pubmed PY - 2017/8/7/medline KW - biodegradable polymers KW - comb‐like polyesters KW - enzymatic polymerization KW - grafted polymers KW - poly(glycerol‐adipate) KW - polyester physical–chemical characterizations SP - 3267 EP - 3278 JF - Journal of polymer science. Part A, Polymer chemistry JO - J Polym Sci A Polym Chem VL - 54 IS - 20 N2 - There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with fatty acid chain length of C4, C8, and C18 (PGAB, PGAO, and PGAS, respectively) at different degrees of substitution were prepared. These modifications yield comb-like polymers that modulate the amphiphilic characteristics of PGA. This novel class of biocompatible polymers has been characterized through various techniques such as FT-IR, 1H NMR, surface, thermal analysis, and their ability to self-assemble into colloidal structures was evaluated by using DLS. The highly tunable properties of PGA reported herein demonstrate a biodegradable polymer platform, ideal for engineering solid dispersions, nanoemulsions, or nanoparticles for healthcare applications. © 2016 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3267-3278. SN - 0887-624X UR - https://www.unboundmedicine.com/medline/citation/28781423/Properties_of_acyl_modified_poly_glycerol_adipate__comb_like_polymers_and_their_self_assembly_into_nanoparticles_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28781423/ DB - PRIME DP - Unbound Medicine ER -