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Outcome comparison in dogs with a presumptive diagnosis of thoracolumbar fibrocartilaginous embolic myelopathy and acute non-compressive nucleus pulposus extrusion.
Vet Rec. 2017 Sep 16; 181(11):293.VR

Abstract

Dogs with fibrocartilaginous embolic myelopathy (FCEM) or acute non-compressive nucleus pulposus extrusion (ANNPE) are reported to have a fair prognosis; however, persistent motor/autonomic deficits are possible. Specific MRI patterns have been suggested to differentiate these diseases although never been validated with histopathology in large studies. The aim of this retrospective study was to evaluate if these MRI patterns are associated with different clinical outcomes in dogs with peracute non-progressive T3-L3 myelopathy. Two hundred and one dogs were included. Outcome data were obtained via medical records and telephone questionnaires. MRIs were blindly reviewed by three board-certified observers, obtaining substantial to almost perfect interobserver agreement on diagnoses (κ=0.635-0.828). Presumptive ANNPE and FCEM were diagnosed in 157 and 44 dogs , respectively. Ambulatory function was regained in 99 per cent of cases, with persistent motor deficits in 83.6 per cent and 92.5 per cent of dogs with presumptive ANNPE and FCEM, respectively. The presumptive diagnosis was not associated with motor function recovery, recovery times or urinary continence. Faecal incontinence was five times more likely in dogs with presumptive ANNPE (23 per cent) compared with presumptive FCEM (7.5 per cent).Distinguishing between MRI patterns of presumptive ANNPE or FCEM in dogs with peracute non-progressive T3-L3 myelopathy may help predict the risk of developing faecal incontinence.

Authors+Show Affiliations

Department of Neurology/Neurosurgery, Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk, UK.Neurology/Neurosurgery Service, Willows Veterinary Centre and Referral Services, Solihull, UK.Department of Neurology/Neurosurgery, Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk, UK.Diagnostic Imaging Service, Centre for Small Animal Studies, Animal Health Trust, Newmarket, UK.Diagnostic Imaging Section, College of Veterinary Medicine, Cornell University, Ithaca, USA.One Health Institute, School of Veterinary Medicine, University of California, Davis, USA.Department of Neurology/Neurosurgery, Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28784693

Citation

Mari, Lorenzo, et al. "Outcome Comparison in Dogs With a Presumptive Diagnosis of Thoracolumbar Fibrocartilaginous Embolic Myelopathy and Acute Non-compressive Nucleus Pulposus Extrusion." The Veterinary Record, vol. 181, no. 11, 2017, p. 293.
Mari L, Behr S, Shea A, et al. Outcome comparison in dogs with a presumptive diagnosis of thoracolumbar fibrocartilaginous embolic myelopathy and acute non-compressive nucleus pulposus extrusion. Vet Rec. 2017;181(11):293.
Mari, L., Behr, S., Shea, A., Dominguez, E., Johnson, P. J., Ekiri, A., & De Risio, L. (2017). Outcome comparison in dogs with a presumptive diagnosis of thoracolumbar fibrocartilaginous embolic myelopathy and acute non-compressive nucleus pulposus extrusion. The Veterinary Record, 181(11), 293. https://doi.org/10.1136/vr.104090
Mari L, et al. Outcome Comparison in Dogs With a Presumptive Diagnosis of Thoracolumbar Fibrocartilaginous Embolic Myelopathy and Acute Non-compressive Nucleus Pulposus Extrusion. Vet Rec. 2017 Sep 16;181(11):293. PubMed PMID: 28784693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome comparison in dogs with a presumptive diagnosis of thoracolumbar fibrocartilaginous embolic myelopathy and acute non-compressive nucleus pulposus extrusion. AU - Mari,Lorenzo, AU - Behr,Sebastien, AU - Shea,Anita, AU - Dominguez,Elisabet, AU - Johnson,Philippa J, AU - Ekiri,Abel, AU - De Risio,Luisa, Y1 - 2017/08/07/ PY - 2016/09/01/received PY - 2017/06/06/revised PY - 2017/06/19/accepted PY - 2017/8/9/pubmed PY - 2017/9/26/medline PY - 2017/8/9/entrez KW - incontinence KW - ischaemic myelopathy KW - neurogenic bowel dysfunction KW - spinal cord injury SP - 293 EP - 293 JF - The Veterinary record JO - Vet Rec VL - 181 IS - 11 N2 - Dogs with fibrocartilaginous embolic myelopathy (FCEM) or acute non-compressive nucleus pulposus extrusion (ANNPE) are reported to have a fair prognosis; however, persistent motor/autonomic deficits are possible. Specific MRI patterns have been suggested to differentiate these diseases although never been validated with histopathology in large studies. The aim of this retrospective study was to evaluate if these MRI patterns are associated with different clinical outcomes in dogs with peracute non-progressive T3-L3 myelopathy. Two hundred and one dogs were included. Outcome data were obtained via medical records and telephone questionnaires. MRIs were blindly reviewed by three board-certified observers, obtaining substantial to almost perfect interobserver agreement on diagnoses (κ=0.635-0.828). Presumptive ANNPE and FCEM were diagnosed in 157 and 44 dogs , respectively. Ambulatory function was regained in 99 per cent of cases, with persistent motor deficits in 83.6 per cent and 92.5 per cent of dogs with presumptive ANNPE and FCEM, respectively. The presumptive diagnosis was not associated with motor function recovery, recovery times or urinary continence. Faecal incontinence was five times more likely in dogs with presumptive ANNPE (23 per cent) compared with presumptive FCEM (7.5 per cent).Distinguishing between MRI patterns of presumptive ANNPE or FCEM in dogs with peracute non-progressive T3-L3 myelopathy may help predict the risk of developing faecal incontinence. SN - 2042-7670 UR - https://www.unboundmedicine.com/medline/citation/28784693/Outcome_comparison_in_dogs_with_a_presumptive_diagnosis_of_thoracolumbar_fibrocartilaginous_embolic_myelopathy_and_acute_non_compressive_nucleus_pulposus_extrusion_ L2 - https://veterinaryrecord.bmj.com/lookup/pmidlookup?view=long&pmid=28784693 DB - PRIME DP - Unbound Medicine ER -