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The strength of the multivariable associations of major risk factors predicting coronary heart disease mortality is homogeneous across different areas of the Seven Countries Study during 50-year follow-up.
Acta Cardiol. 2018 Apr; 73(2):148-154.AC

Abstract

OBJECTIVES

To compare the magnitude of multivariable coefficients and hazard ratios of four cardiovascular risk factors across five worldwide regions of the Seven Countries Study in predicting 50-year coronary deaths.

MATERIAL AND METHODS

A total of 13 cohorts of middle-aged men at entry (40-59 years old) were enrolled in the mid-1900s from five relatively homogeneous groups of cohorts (areas): USA, Finland and Zutphen - the Netherlands, Italy and Greece, Serbia, Japan for a total of 10,368 middle-aged men. The major risk factors measured at baseline were age, number of cigarettes smoked, systolic blood pressure and serum cholesterol. Cox proportional hazards models were solved for 50-year (45 years for Serbia) deaths from coronary heart disease (CHD), and the multivariable coefficients were compared for heterogeneity.

RESULTS

The highest levels of risk factors and CHD death rates were found in Finland and Zutphen - the Netherlands and the lowest in Japan. All four risk factors were predictive for long-term CHD mortality in all regions, except serum cholesterol in Japan where the mean levels and CHD events were lowest. Tests of heterogeneity of coefficients for single risk factors in predicting CHD mortality were non-significant across the five areas. The same analyses for the first 25 years of follow-up produced similar findings.

CONCLUSIONS

The strength of the multivariable associations of four major traditional CHD risk factors with long-term CHD mortality appears to be relatively homogeneous across areas, pending needed further evidence.

Authors+Show Affiliations

a Association for Cardiac Research , Rome , Italy.b Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences , Sapienza University of Rome , Rome , Italy.c Department of Internal Medicine, Division of Cardio-Vascular Medicine , Kurume University School of Medicine , Kurume , Japan.d School of Public Health, Department of Social Medicine and Nutrition , University of Crete , Heraklion , Greece.e National Institute for Health and Welfare (THL), Department of Health , Helsinki , Finland.f Department of Epidemiology, University Medical Center Groningen , University of Groningen and Division of Human Nutrition, Wageningen University , The Netherlands.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28786758

Citation

Menotti, Alessandro, et al. "The Strength of the Multivariable Associations of Major Risk Factors Predicting Coronary Heart Disease Mortality Is Homogeneous Across Different Areas of the Seven Countries Study During 50-year Follow-up." Acta Cardiologica, vol. 73, no. 2, 2018, pp. 148-154.
Menotti A, Puddu PE, Adachi H, et al. The strength of the multivariable associations of major risk factors predicting coronary heart disease mortality is homogeneous across different areas of the Seven Countries Study during 50-year follow-up. Acta Cardiol. 2018;73(2):148-154.
Menotti, A., Puddu, P. E., Adachi, H., Kafatos, A., Tolonen, H., & Kromhout, D. (2018). The strength of the multivariable associations of major risk factors predicting coronary heart disease mortality is homogeneous across different areas of the Seven Countries Study during 50-year follow-up. Acta Cardiologica, 73(2), 148-154. https://doi.org/10.1080/00015385.2017.1351249
Menotti A, et al. The Strength of the Multivariable Associations of Major Risk Factors Predicting Coronary Heart Disease Mortality Is Homogeneous Across Different Areas of the Seven Countries Study During 50-year Follow-up. Acta Cardiol. 2018;73(2):148-154. PubMed PMID: 28786758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The strength of the multivariable associations of major risk factors predicting coronary heart disease mortality is homogeneous across different areas of the Seven Countries Study during 50-year follow-up. AU - Menotti,Alessandro, AU - Puddu,Paolo Emilio, AU - Adachi,Hisashi, AU - Kafatos,Anthony, AU - Tolonen,Hanna, AU - Kromhout,Daan, Y1 - 2017/08/08/ PY - 2017/8/9/pubmed PY - 2019/9/4/medline PY - 2017/8/9/entrez KW - Coronary heart disease KW - coefficients KW - hazard ratios KW - homogeneity KW - mortality KW - prediction KW - risk factors SP - 148 EP - 154 JF - Acta cardiologica JO - Acta Cardiol VL - 73 IS - 2 N2 - OBJECTIVES: To compare the magnitude of multivariable coefficients and hazard ratios of four cardiovascular risk factors across five worldwide regions of the Seven Countries Study in predicting 50-year coronary deaths. MATERIAL AND METHODS: A total of 13 cohorts of middle-aged men at entry (40-59 years old) were enrolled in the mid-1900s from five relatively homogeneous groups of cohorts (areas): USA, Finland and Zutphen - the Netherlands, Italy and Greece, Serbia, Japan for a total of 10,368 middle-aged men. The major risk factors measured at baseline were age, number of cigarettes smoked, systolic blood pressure and serum cholesterol. Cox proportional hazards models were solved for 50-year (45 years for Serbia) deaths from coronary heart disease (CHD), and the multivariable coefficients were compared for heterogeneity. RESULTS: The highest levels of risk factors and CHD death rates were found in Finland and Zutphen - the Netherlands and the lowest in Japan. All four risk factors were predictive for long-term CHD mortality in all regions, except serum cholesterol in Japan where the mean levels and CHD events were lowest. Tests of heterogeneity of coefficients for single risk factors in predicting CHD mortality were non-significant across the five areas. The same analyses for the first 25 years of follow-up produced similar findings. CONCLUSIONS: The strength of the multivariable associations of four major traditional CHD risk factors with long-term CHD mortality appears to be relatively homogeneous across areas, pending needed further evidence. SN - 0001-5385 UR - https://www.unboundmedicine.com/medline/citation/28786758/The_strength_of_the_multivariable_associations_of_major_risk_factors_predicting_coronary_heart_disease_mortality_is_homogeneous_across_different_areas_of_the_Seven_Countries_Study_during_50_year_follow_up_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -