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The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly.
Clin Endocrinol (Oxf). 1986 Aug; 25(2):201-12.CE

Abstract

The somatostatin analogue SMS 201-995 has recently been shown to be effective in suppressing GH secretion in most acromegalic patients. In the present study it was investigated whether PRL release in prolactinoma and acromegalic patients might also be sensitive to SMS 201-995 and whether co-secretion of PRL in acromegaly plays a role in determining the sensitivity of GH secretion to SMS 201-995. The s.c. administration of 50 micrograms SMS 201-995 did not affect high plasma PRL levels in four microprolactinoma patients. Therapy of one of these patients for 3 d with 50 micrograms three times a day also did not affect PRL levels. The single administration of 50 micrograms SMS 201-995 in 22 acromegalic patients lowered plasma GH levels for 2-6 h to less than 5 micrograms/l in 14 patients and to less than 50% of control values in 16 patients. In 18 of these 22 patients the immunohistochemical picture of the pituitary tumour was known. Eleven patients had pure GH-containing tumours and in seven patients there were mixed GH/PRL-containing tumours. In two of these latter patients there was evidence for GH and PRL being secreted by the same tumour cells. The sensitivity of GH secretion to SMS 201-995 did not differ between the patients with pure GH or mixed GH/PRL-containing adenomas. Plasma PRL levels were not affected by SMS 201-995 in the patients with pure GH-secreting tumours, but were significantly suppressed in four of the seven patients with mixed GH/PRL containing tumours. Chronic treatment for 16 weeks of one patient with a mixed GH/PRL-containing tumour with SMS 201-995 (100 micrograms three times a day) resulted in normalization of both the increased GH and PRL levels. It is concluded that SMS 201-995 does not affect tumorous PRL secretion in patients with pure prolactinomas. In acromegalic patients with mixed GH/PRL-containing tumours PRL secretion in some patients is sensitive to SMS 201-995, making these patients good candidates for chronic treatment with the analogue. The simultaneous presence of PRL in the GH-secreting pituitary tumour or the presence of hyperprolactinaemia in acromegalics does not play a role in the sensitivity of GH secretion to the somatostatin analogue.

Authors

Lamberts SW
No affiliation info available
Zweens M
No affiliation info available
Klijn JG
No affiliation info available
van Vroonhoven CC
No affiliation info available
Stefanko SZ
No affiliation info available
Del Pozo E
No affiliation info available

MeSH

AcromegalyAdultAgedFemaleGrowth HormoneHumansMaleMiddle AgedOctreotidePituitary NeoplasmsProlactinSecretory RateSomatostatin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2878748

Citation

Lamberts, S W., et al. "The Sensitivity of Growth Hormone and Prolactin Secretion to the Somatostatin Analogue SMS 201-995 in Patients With Prolactinomas and Acromegaly." Clinical Endocrinology, vol. 25, no. 2, 1986, pp. 201-12.
Lamberts SW, Zweens M, Klijn JG, et al. The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly. Clin Endocrinol (Oxf). 1986;25(2):201-12.
Lamberts, S. W., Zweens, M., Klijn, J. G., van Vroonhoven, C. C., Stefanko, S. Z., & Del Pozo, E. (1986). The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly. Clinical Endocrinology, 25(2), 201-12.
Lamberts SW, et al. The Sensitivity of Growth Hormone and Prolactin Secretion to the Somatostatin Analogue SMS 201-995 in Patients With Prolactinomas and Acromegaly. Clin Endocrinol (Oxf). 1986;25(2):201-12. PubMed PMID: 2878748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly. AU - Lamberts,S W, AU - Zweens,M, AU - Klijn,J G, AU - van Vroonhoven,C C, AU - Stefanko,S Z, AU - Del Pozo,E, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 201 EP - 12 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 25 IS - 2 N2 - The somatostatin analogue SMS 201-995 has recently been shown to be effective in suppressing GH secretion in most acromegalic patients. In the present study it was investigated whether PRL release in prolactinoma and acromegalic patients might also be sensitive to SMS 201-995 and whether co-secretion of PRL in acromegaly plays a role in determining the sensitivity of GH secretion to SMS 201-995. The s.c. administration of 50 micrograms SMS 201-995 did not affect high plasma PRL levels in four microprolactinoma patients. Therapy of one of these patients for 3 d with 50 micrograms three times a day also did not affect PRL levels. The single administration of 50 micrograms SMS 201-995 in 22 acromegalic patients lowered plasma GH levels for 2-6 h to less than 5 micrograms/l in 14 patients and to less than 50% of control values in 16 patients. In 18 of these 22 patients the immunohistochemical picture of the pituitary tumour was known. Eleven patients had pure GH-containing tumours and in seven patients there were mixed GH/PRL-containing tumours. In two of these latter patients there was evidence for GH and PRL being secreted by the same tumour cells. The sensitivity of GH secretion to SMS 201-995 did not differ between the patients with pure GH or mixed GH/PRL-containing adenomas. Plasma PRL levels were not affected by SMS 201-995 in the patients with pure GH-secreting tumours, but were significantly suppressed in four of the seven patients with mixed GH/PRL containing tumours. Chronic treatment for 16 weeks of one patient with a mixed GH/PRL-containing tumour with SMS 201-995 (100 micrograms three times a day) resulted in normalization of both the increased GH and PRL levels. It is concluded that SMS 201-995 does not affect tumorous PRL secretion in patients with pure prolactinomas. In acromegalic patients with mixed GH/PRL-containing tumours PRL secretion in some patients is sensitive to SMS 201-995, making these patients good candidates for chronic treatment with the analogue. The simultaneous presence of PRL in the GH-secreting pituitary tumour or the presence of hyperprolactinaemia in acromegalics does not play a role in the sensitivity of GH secretion to the somatostatin analogue. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/2878748/The_sensitivity_of_growth_hormone_and_prolactin_secretion_to_the_somatostatin_analogue_SMS_201_995_in_patients_with_prolactinomas_and_acromegaly_ DB - PRIME DP - Unbound Medicine ER -