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Different changes of n-6 and n-3 fatty acids in adipose tissue from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with linolenic or eicosapentaenoic acids.
Prostaglandins Leukot Med. 1986 Oct; 24(2-3):163-72.PL

Abstract

In spontaneously hypertensive (SHR) and normotensive rats of the Wistar-Kyoto (WKY) and Wistar-Schönwalde (WSCHOE) strain, diets supplemented with n-3 fatty acids of different chain length (alpha-linolenic acid, LNA--C 18:3, n-3 with linseed oil and eicosapentaenoic acid, EPA--C 20:5, n-3 with cod liver oil) were fed over a period of 22 weeks. After the LNA-rich diet, among the long-chain n-3 fatty acids EPA in epididymal adipose tissue remained unchanged, whereas docosapentaenoic (DPA) and docosahexaenoic acids (DHA) fell. The n-6 fatty acids linoleic (LA) and arachidonic acid (AA) both appeared decreased. After the EPA-rich diet, all n-3 fatty acids, i.e. not only EPA, DPA and DHA, but also LNA were augmented when compared with controls fed commercially available pellets. Among the n-6 fatty acids LA was extremely depressed, whereas AA appeared increased. The p/s-ratio was elevated after the LNA-rich diet, but decreased after the EPA-rich diet. The data indicate a differential effect of dietary n-3 fatty acids of different chain length on the supply of other n-3 fatty acids, of LA and AA as well as on the p/s-ratio in adipose tissue of rats. Blood pressure was not influenced by either diet in either SHR or in both normotensive strains of rats.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2879291

Citation

Singer, P, et al. "Different Changes of N-6 and N-3 Fatty Acids in Adipose Tissue From Spontaneously Hypertensive (SHR) and Normotensive Rats After Diets Supplemented With Linolenic or Eicosapentaenoic Acids." Prostaglandins, Leukotrienes, and Medicine, vol. 24, no. 2-3, 1986, pp. 163-72.
Singer P, Gerhard U, Moritz V, et al. Different changes of n-6 and n-3 fatty acids in adipose tissue from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with linolenic or eicosapentaenoic acids. Prostaglandins Leukot Med. 1986;24(2-3):163-72.
Singer, P., Gerhard, U., Moritz, V., Förster, D., Berger, I., & Heine, H. (1986). Different changes of n-6 and n-3 fatty acids in adipose tissue from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with linolenic or eicosapentaenoic acids. Prostaglandins, Leukotrienes, and Medicine, 24(2-3), 163-72.
Singer P, et al. Different Changes of N-6 and N-3 Fatty Acids in Adipose Tissue From Spontaneously Hypertensive (SHR) and Normotensive Rats After Diets Supplemented With Linolenic or Eicosapentaenoic Acids. Prostaglandins Leukot Med. 1986;24(2-3):163-72. PubMed PMID: 2879291.
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TY - JOUR T1 - Different changes of n-6 and n-3 fatty acids in adipose tissue from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with linolenic or eicosapentaenoic acids. AU - Singer,P, AU - Gerhard,U, AU - Moritz,V, AU - Förster,D, AU - Berger,I, AU - Heine,H, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 163 EP - 72 JF - Prostaglandins, leukotrienes, and medicine JO - Prostaglandins Leukot Med VL - 24 IS - 2-3 N2 - In spontaneously hypertensive (SHR) and normotensive rats of the Wistar-Kyoto (WKY) and Wistar-Schönwalde (WSCHOE) strain, diets supplemented with n-3 fatty acids of different chain length (alpha-linolenic acid, LNA--C 18:3, n-3 with linseed oil and eicosapentaenoic acid, EPA--C 20:5, n-3 with cod liver oil) were fed over a period of 22 weeks. After the LNA-rich diet, among the long-chain n-3 fatty acids EPA in epididymal adipose tissue remained unchanged, whereas docosapentaenoic (DPA) and docosahexaenoic acids (DHA) fell. The n-6 fatty acids linoleic (LA) and arachidonic acid (AA) both appeared decreased. After the EPA-rich diet, all n-3 fatty acids, i.e. not only EPA, DPA and DHA, but also LNA were augmented when compared with controls fed commercially available pellets. Among the n-6 fatty acids LA was extremely depressed, whereas AA appeared increased. The p/s-ratio was elevated after the LNA-rich diet, but decreased after the EPA-rich diet. The data indicate a differential effect of dietary n-3 fatty acids of different chain length on the supply of other n-3 fatty acids, of LA and AA as well as on the p/s-ratio in adipose tissue of rats. Blood pressure was not influenced by either diet in either SHR or in both normotensive strains of rats. SN - 0262-1746 UR - https://www.unboundmedicine.com/medline/citation/2879291/Different_changes_of_n_6_and_n_3_fatty_acids_in_adipose_tissue_from_spontaneously_hypertensive__SHR__and_normotensive_rats_after_diets_supplemented_with_linolenic_or_eicosapentaenoic_acids_ DB - PRIME DP - Unbound Medicine ER -