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Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes.

Abstract

Proinflammatory dietary patterns have been associated with increased cancer risk and mortality. We present a systematic review and meta-analysis of the current published literature on a dietary inflammatory index (DII) score and its association with cancer risk and mortality outcomes. Published articles from online databases (PubMed, Scopus, and Embase) examining the association between DII and any cancer risk, incidence, or mortality between 1980 and November 2016 were selected for review. Results of studies meeting inclusion criteria were summarized and meta-analyzed using STATA to generate summary measures of association across studies. Sixty-three published articles were identified from the search, and following title, abstract and full-text review, twenty-four studies met inclusion criteria. All articles calculated DII scores based on study-specific food-frequency questionnaires using methodology from the same article. Of the 24 included studies, 13 were case-control, 6 were prospective cohort, 1 was a retrospective cohort, 3 were RCTs, and 1 did not specify study design. The most common cancers examined were colorectal, breast, lung, and prostate. Individuals in the highest versus lowest DII categories had 25% increased risk of overall cancer incidence (RR: 1.25, 95% CI: 1.16-1.35), 75% higher odds of cancer (OR: 1.75, 95% CI: 1.43-2.16) and 67% increased risk of cancer mortality (RR: 1.67, 95% CI: 1.13-2.48). Upon stratification for cancer type, positive associations remained (RRbreast : RR: 1.12, 95% CI: 1.03-1.22) (RRcolorectal : 1.33, 95% CI: 1.22-1.46) (RRlung : 1.30, 95% CI: 1.13-1.50). There were consistent and significant positive associations between higher DII and cancer incidence and mortality across cancer types, study populations, and study design.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.

    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL. Department of Epidemiology, University of Kentucky, Lexington, KY.

    Source

    International journal of cancer 141:11 2017 12 01 pg 2215-2227

    MeSH

    Diet
    Humans
    Inflammation
    Neoplasms

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    28795402

    Citation

    Fowler, Mackenzie E., and Tomi F. Akinyemiju. "Meta-analysis of the Association Between Dietary Inflammatory Index (DII) and Cancer Outcomes." International Journal of Cancer, vol. 141, no. 11, 2017, pp. 2215-2227.
    Fowler ME, Akinyemiju TF. Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes. Int J Cancer. 2017;141(11):2215-2227.
    Fowler, M. E., & Akinyemiju, T. F. (2017). Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes. International Journal of Cancer, 141(11), pp. 2215-2227. doi:10.1002/ijc.30922.
    Fowler ME, Akinyemiju TF. Meta-analysis of the Association Between Dietary Inflammatory Index (DII) and Cancer Outcomes. Int J Cancer. 2017 12 1;141(11):2215-2227. PubMed PMID: 28795402.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes. AU - Fowler,Mackenzie E, AU - Akinyemiju,Tomi F, Y1 - 2017/08/26/ PY - 2017/05/11/received PY - 2017/06/27/revised PY - 2017/07/25/accepted PY - 2017/8/11/pubmed PY - 2017/10/21/medline PY - 2017/8/11/entrez KW - cancer incidence KW - cancer mortality KW - diet KW - dietary inflammatory index KW - pro-inflammatory diet SP - 2215 EP - 2227 JF - International journal of cancer JO - Int. J. Cancer VL - 141 IS - 11 N2 - Proinflammatory dietary patterns have been associated with increased cancer risk and mortality. We present a systematic review and meta-analysis of the current published literature on a dietary inflammatory index (DII) score and its association with cancer risk and mortality outcomes. Published articles from online databases (PubMed, Scopus, and Embase) examining the association between DII and any cancer risk, incidence, or mortality between 1980 and November 2016 were selected for review. Results of studies meeting inclusion criteria were summarized and meta-analyzed using STATA to generate summary measures of association across studies. Sixty-three published articles were identified from the search, and following title, abstract and full-text review, twenty-four studies met inclusion criteria. All articles calculated DII scores based on study-specific food-frequency questionnaires using methodology from the same article. Of the 24 included studies, 13 were case-control, 6 were prospective cohort, 1 was a retrospective cohort, 3 were RCTs, and 1 did not specify study design. The most common cancers examined were colorectal, breast, lung, and prostate. Individuals in the highest versus lowest DII categories had 25% increased risk of overall cancer incidence (RR: 1.25, 95% CI: 1.16-1.35), 75% higher odds of cancer (OR: 1.75, 95% CI: 1.43-2.16) and 67% increased risk of cancer mortality (RR: 1.67, 95% CI: 1.13-2.48). Upon stratification for cancer type, positive associations remained (RRbreast : RR: 1.12, 95% CI: 1.03-1.22) (RRcolorectal : 1.33, 95% CI: 1.22-1.46) (RRlung : 1.30, 95% CI: 1.13-1.50). There were consistent and significant positive associations between higher DII and cancer incidence and mortality across cancer types, study populations, and study design. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/28795402/Meta_analysis_of_the_association_between_dietary_inflammatory_index__DII__and_cancer_outcomes_ L2 - https://doi.org/10.1002/ijc.30922 DB - PRIME DP - Unbound Medicine ER -