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Effective long-term treatment of acromegaly with a long-acting somatostatin analogue (SMS 201-995).
Clin Endocrinol (Oxf). 1987 Jan; 26(1):85-95.CE

Abstract

Nine acromegalic patients, six previously untreated, were studied before and after 3-15 months of treatment with a long-acting somatostatin analogue (SMS 201-995; 100 micrograms injected s.c. three times daily). During treatment, the mean (+/- SEM) 24-h GH concentration fell from 82 +/- 22 mIU/l to 33 +/- 7 mIU/l (P less than 0.001), and eight of the 9 patients showed a reduction of at least 50% in GH levels in the fasting state and/or during a glucose tolerance test. There was a significant 30% fall in serum concentrations of insulin-like growth factor (IGF-1) with SMS. All patients showed rapid clinical improvement, with diminished sweating and headaches, and reduction in skinfold thickness, hand volumes and finger size. Computer tomographic scanning of the pituitary in eight patients showed no change in the size of the pituitary tumour during treatment. The only side-effects of SMS noted were transient abdominal discomfort and loose stools in two patients on initiating therapy. Although fasting plasma glucose concentration did not change during treatment (5.4 +/- 0.3 vs 5.5 +/- 0.3 mmol/l), mean 24-h plasma glucose concentration was higher with SMS (6.6 +/- 0.5 mmol/l vs 6.0 +/- 0.4 mmol/l; P less than 0.02). Mean 24-h plasma insulin concentration fell from 87 +/- 11 mIU/l before treatment to 39 +/- 6 mIU/l during treatment (P less than 0.005). No change in other anterior pituitary hormones was observed. SMS appears to be a safe, rapidly effective, long-term treatment for certain patients with acromegaly.

Authors

Sandler LM
No affiliation info available
Burrin JM
No affiliation info available
Williams G
No affiliation info available
Joplin GF
No affiliation info available
Carr DH
No affiliation info available
Bloom SR
No affiliation info available

MeSH

AcromegalyAdultBlood GlucoseFemaleGrowth HormoneHumansInsulinMaleMiddle AgedOctreotideSomatostatinTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2879656

Citation

Sandler, L M., et al. "Effective Long-term Treatment of Acromegaly With a Long-acting Somatostatin Analogue (SMS 201-995)." Clinical Endocrinology, vol. 26, no. 1, 1987, pp. 85-95.
Sandler LM, Burrin JM, Williams G, et al. Effective long-term treatment of acromegaly with a long-acting somatostatin analogue (SMS 201-995). Clin Endocrinol (Oxf). 1987;26(1):85-95.
Sandler, L. M., Burrin, J. M., Williams, G., Joplin, G. F., Carr, D. H., & Bloom, S. R. (1987). Effective long-term treatment of acromegaly with a long-acting somatostatin analogue (SMS 201-995). Clinical Endocrinology, 26(1), 85-95.
Sandler LM, et al. Effective Long-term Treatment of Acromegaly With a Long-acting Somatostatin Analogue (SMS 201-995). Clin Endocrinol (Oxf). 1987;26(1):85-95. PubMed PMID: 2879656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effective long-term treatment of acromegaly with a long-acting somatostatin analogue (SMS 201-995). AU - Sandler,L M, AU - Burrin,J M, AU - Williams,G, AU - Joplin,G F, AU - Carr,D H, AU - Bloom,S R, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 85 EP - 95 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 26 IS - 1 N2 - Nine acromegalic patients, six previously untreated, were studied before and after 3-15 months of treatment with a long-acting somatostatin analogue (SMS 201-995; 100 micrograms injected s.c. three times daily). During treatment, the mean (+/- SEM) 24-h GH concentration fell from 82 +/- 22 mIU/l to 33 +/- 7 mIU/l (P less than 0.001), and eight of the 9 patients showed a reduction of at least 50% in GH levels in the fasting state and/or during a glucose tolerance test. There was a significant 30% fall in serum concentrations of insulin-like growth factor (IGF-1) with SMS. All patients showed rapid clinical improvement, with diminished sweating and headaches, and reduction in skinfold thickness, hand volumes and finger size. Computer tomographic scanning of the pituitary in eight patients showed no change in the size of the pituitary tumour during treatment. The only side-effects of SMS noted were transient abdominal discomfort and loose stools in two patients on initiating therapy. Although fasting plasma glucose concentration did not change during treatment (5.4 +/- 0.3 vs 5.5 +/- 0.3 mmol/l), mean 24-h plasma glucose concentration was higher with SMS (6.6 +/- 0.5 mmol/l vs 6.0 +/- 0.4 mmol/l; P less than 0.02). Mean 24-h plasma insulin concentration fell from 87 +/- 11 mIU/l before treatment to 39 +/- 6 mIU/l during treatment (P less than 0.005). No change in other anterior pituitary hormones was observed. SMS appears to be a safe, rapidly effective, long-term treatment for certain patients with acromegaly. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/2879656/Effective_long_term_treatment_of_acromegaly_with_a_long_acting_somatostatin_analogue__SMS_201_995__ DB - PRIME DP - Unbound Medicine ER -