Tags

Type your tag names separated by a space and hit enter

Impact of anxiety, apathy and reduced functional autonomy on perceived quality of life in Parkinson's disease.
Parkinsonism Relat Disord. 2017 Oct; 43:114-117.PR

Abstract

INTRODUCTION

Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD.

METHODS

Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment. The perceived QoL was assessed by Parkinson's Disease Questionnaire (PDQ-8). The PD sample was divided into patients with high and low HRQoL around the median of PDQ-8 and compared on clinical features, cognitive and neuropsychiatric variables. A linear regression analysis, in which the global functioning, apathy, depression, anxiety, anhedonia, ICD and the functional autonomy scores were entered as independent variables and PDQ-8 score as dependent variable, was applied.

RESULTS

Patients with lower HRQoL were more depressed, apathetic, anxious and showed more severe reduction of functional autonomy and global functioning than patients with high HRQoL. The regression analysis revealed that higher level of anxiety, executive apathy and more reduced functional autonomy were significantly associated with higher score on PDQ-8.

CONCLUSIONS

The finding indicated that anxiety, apathy associated with impaired planning, attention and organization (i.e., executive apathy evaluated by the Dimensional Apathy Scale) and reduced functional autonomy contribute significantly to reduce the HRQoL in PD. Therefore, early identification and management of these neuropsychiatric symptoms should be relevant to preserve HRQoL in PD.

Authors+Show Affiliations

Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy.Department of Motor Sciences and Wellness, University "Parthenope", Naples, Italy; Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy.Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy.Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy.Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy.Department of Motor Sciences and Wellness, University "Parthenope", Naples, Italy; Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy.Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy; Department of Medicine, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Italy.Department of Medicine, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Italy.Neuropsychology and Memory Clinic, Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy; Institute of Diagnosis and Care (IDC), Hermitage-Capodimonte, Naples, Italy. Electronic address: gabriella.santangelo@unicampania.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28797564

Citation

D'Iorio, Alfonsina, et al. "Impact of Anxiety, Apathy and Reduced Functional Autonomy On Perceived Quality of Life in Parkinson's Disease." Parkinsonism & Related Disorders, vol. 43, 2017, pp. 114-117.
D'Iorio A, Vitale C, Piscopo F, et al. Impact of anxiety, apathy and reduced functional autonomy on perceived quality of life in Parkinson's disease. Parkinsonism Relat Disord. 2017;43:114-117.
D'Iorio, A., Vitale, C., Piscopo, F., Baiano, C., Falanga, A. P., Longo, K., Amboni, M., Barone, P., & Santangelo, G. (2017). Impact of anxiety, apathy and reduced functional autonomy on perceived quality of life in Parkinson's disease. Parkinsonism & Related Disorders, 43, 114-117. https://doi.org/10.1016/j.parkreldis.2017.08.003
D'Iorio A, et al. Impact of Anxiety, Apathy and Reduced Functional Autonomy On Perceived Quality of Life in Parkinson's Disease. Parkinsonism Relat Disord. 2017;43:114-117. PubMed PMID: 28797564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of anxiety, apathy and reduced functional autonomy on perceived quality of life in Parkinson's disease. AU - D'Iorio,Alfonsina, AU - Vitale,Carmine, AU - Piscopo,Fausta, AU - Baiano,Chiara, AU - Falanga,Anna Paola, AU - Longo,Katia, AU - Amboni,Marianna, AU - Barone,Paolo, AU - Santangelo,Gabriella, Y1 - 2017/08/05/ PY - 2017/04/27/received PY - 2017/07/31/revised PY - 2017/08/02/accepted PY - 2017/8/12/pubmed PY - 2018/6/13/medline PY - 2017/8/12/entrez KW - Anxiety KW - Apathy KW - Neuropsychiatric disorders KW - Parkinson's disease KW - Quality of life SP - 114 EP - 117 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 43 N2 - INTRODUCTION: Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment. The perceived QoL was assessed by Parkinson's Disease Questionnaire (PDQ-8). The PD sample was divided into patients with high and low HRQoL around the median of PDQ-8 and compared on clinical features, cognitive and neuropsychiatric variables. A linear regression analysis, in which the global functioning, apathy, depression, anxiety, anhedonia, ICD and the functional autonomy scores were entered as independent variables and PDQ-8 score as dependent variable, was applied. RESULTS: Patients with lower HRQoL were more depressed, apathetic, anxious and showed more severe reduction of functional autonomy and global functioning than patients with high HRQoL. The regression analysis revealed that higher level of anxiety, executive apathy and more reduced functional autonomy were significantly associated with higher score on PDQ-8. CONCLUSIONS: The finding indicated that anxiety, apathy associated with impaired planning, attention and organization (i.e., executive apathy evaluated by the Dimensional Apathy Scale) and reduced functional autonomy contribute significantly to reduce the HRQoL in PD. Therefore, early identification and management of these neuropsychiatric symptoms should be relevant to preserve HRQoL in PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/28797564/Impact_of_anxiety_apathy_and_reduced_functional_autonomy_on_perceived_quality_of_life_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(17)30284-5 DB - PRIME DP - Unbound Medicine ER -