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Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population.
Adv Exp Med Biol. 2018; 1039:35-44.AE

Abstract

Histamine intolerance (pseudoallergy) is a poorly investigated type of food hypersensitivity. The main enzyme responsible for histamine degradation in the extracellular matrix is diamine oxidase (DAO). Disturbances in the concentration or activity of DAO may lead to the development of clinical signs of allergy. The aim of the present work was to assess the DAO concentration, peripheral blood morphology, lymphocytes phenotyping (CD3+, CD4+, CD8+, CD19+, NK cells, NKT cells, and activated T-cells), and natural regulatory Treg (nTregs) cell population (CD4+, CD25+, CD127low, and FoxP3) in 34 pediatric patients with histamine-dependent syndromes. Patients were divided into two groups: classical allergy and pseudoallergy on the basis of IgE concentration. The investigation was based on the analysis of peripheral blood samples. A significantly lower serum DAO, both total and specific IgE, concentration was found in the pseudoallergy group compared with the allergy group. There were no significant differences in blood morphology or lymphocyte populations. A similar level of nTreg lymphocytes was also found in both groups, although it was lower than that present in healthy individuals. The findings suggest that the serum DAO is responsible for the symptoms of histamine intolerance. Moreover, a general decrease in nTreg cells in comparison with healthy individuals may lead to symptom aggravation.

Authors+Show Affiliations

Department of Pediatrics, Pediatric Nephrology and Allergology, Military Institute of Medicine, 128 Szaserów, 04-141, Warsaw, Poland. jkacik@wim.mil.pl.Department of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.Department of Pediatrics, Pediatric Nephrology and Allergology, Military Institute of Medicine, 128 Szaserów, 04-141, Warsaw, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28804811

Citation

Kacik, Joanna, et al. "Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population." Advances in Experimental Medicine and Biology, vol. 1039, 2018, pp. 35-44.
Kacik J, Wróblewska B, Lewicki S, et al. Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population. Adv Exp Med Biol. 2018;1039:35-44.
Kacik, J., Wróblewska, B., Lewicki, S., Zdanowski, R., & Kalicki, B. (2018). Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population. Advances in Experimental Medicine and Biology, 1039, 35-44. https://doi.org/10.1007/5584_2017_81
Kacik J, et al. Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population. Adv Exp Med Biol. 2018;1039:35-44. PubMed PMID: 28804811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population. AU - Kacik,Joanna, AU - Wróblewska,Barbara, AU - Lewicki,Sławomir, AU - Zdanowski,Robert, AU - Kalicki,Bolesław, PY - 2017/8/15/pubmed PY - 2018/5/4/medline PY - 2017/8/15/entrez KW - Allergy KW - Angioedema KW - Dermal lesions KW - Headache KW - Immunological disorders KW - Stomachache SP - 35 EP - 44 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 1039 N2 - Histamine intolerance (pseudoallergy) is a poorly investigated type of food hypersensitivity. The main enzyme responsible for histamine degradation in the extracellular matrix is diamine oxidase (DAO). Disturbances in the concentration or activity of DAO may lead to the development of clinical signs of allergy. The aim of the present work was to assess the DAO concentration, peripheral blood morphology, lymphocytes phenotyping (CD3+, CD4+, CD8+, CD19+, NK cells, NKT cells, and activated T-cells), and natural regulatory Treg (nTregs) cell population (CD4+, CD25+, CD127low, and FoxP3) in 34 pediatric patients with histamine-dependent syndromes. Patients were divided into two groups: classical allergy and pseudoallergy on the basis of IgE concentration. The investigation was based on the analysis of peripheral blood samples. A significantly lower serum DAO, both total and specific IgE, concentration was found in the pseudoallergy group compared with the allergy group. There were no significant differences in blood morphology or lymphocyte populations. A similar level of nTreg lymphocytes was also found in both groups, although it was lower than that present in healthy individuals. The findings suggest that the serum DAO is responsible for the symptoms of histamine intolerance. Moreover, a general decrease in nTreg cells in comparison with healthy individuals may lead to symptom aggravation. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/28804811/Serum_Diamine_Oxidase_in_Pseudoallergy_in_the_Pediatric_Population_ L2 - https://dx.doi.org/10.1007/5584_2017_81 DB - PRIME DP - Unbound Medicine ER -