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Hypopigmented Mycosis Fungoides with Large Cell Transformation in a Child.
Pediatr Dermatol. 2017 Sep; 34(5):e260-e264.PD

Abstract

Hypopigmented mycosis fungoides (HMF) is the most common variant of mycosis fungoides (MF) in children. Large-cell transformation in HMF has never been reported. Herein we report a case of HMF in an 8-year-old boy who presented with a 6-year history of hypopigmented patches on the bilateral arms, lower back, buttocks, posterior thighs, and lower legs. Biopsy revealed an abnormal CD8[+] epidermotropic T-cell infiltrate consistent with the diagnosis of MF. The T-cell clonality study was positive. The patient was started on narrowband ultraviolet B (NBUVB) phototherapy and topical steroids. He had a 50% reduction in his patches after 10 months of treatment, after which he developed a single annular plaque on his left thigh. The biopsy specimen demonstrated large cells that were diffusely CD8[+] and CD30[-] . Clobetasol propionate ointment was prescribed, which led to complete resolution of the plaque within 2 weeks. NBUVB phototherapy was continued and the patient had a complete response within the following 5 months. The case is an example of exceptionally rare large-cell transformation in pediatric MF and stresses the importance of regular follow-up of these patients.

Authors+Show Affiliations

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.Dermatopathology Unit, University of Pittsburgh, Pittsburgh, Pennsylvania.Dermatopathology Unit, University of Pittsburgh, Pittsburgh, Pennsylvania.Cutaneous Lymphoma Program, Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28804923

Citation

Pradhan, Dinesh, et al. "Hypopigmented Mycosis Fungoides With Large Cell Transformation in a Child." Pediatric Dermatology, vol. 34, no. 5, 2017, pp. e260-e264.
Pradhan D, Jedrych JJ, Ho J, et al. Hypopigmented Mycosis Fungoides with Large Cell Transformation in a Child. Pediatr Dermatol. 2017;34(5):e260-e264.
Pradhan, D., Jedrych, J. J., Ho, J., & Akilov, O. E. (2017). Hypopigmented Mycosis Fungoides with Large Cell Transformation in a Child. Pediatric Dermatology, 34(5), e260-e264. https://doi.org/10.1111/pde.13233
Pradhan D, et al. Hypopigmented Mycosis Fungoides With Large Cell Transformation in a Child. Pediatr Dermatol. 2017;34(5):e260-e264. PubMed PMID: 28804923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypopigmented Mycosis Fungoides with Large Cell Transformation in a Child. AU - Pradhan,Dinesh, AU - Jedrych,Jaroslaw J, AU - Ho,Jonhan, AU - Akilov,Oleg E, Y1 - 2017/08/14/ PY - 2017/8/15/pubmed PY - 2018/5/22/medline PY - 2017/8/15/entrez SP - e260 EP - e264 JF - Pediatric dermatology JO - Pediatr Dermatol VL - 34 IS - 5 N2 - Hypopigmented mycosis fungoides (HMF) is the most common variant of mycosis fungoides (MF) in children. Large-cell transformation in HMF has never been reported. Herein we report a case of HMF in an 8-year-old boy who presented with a 6-year history of hypopigmented patches on the bilateral arms, lower back, buttocks, posterior thighs, and lower legs. Biopsy revealed an abnormal CD8[+] epidermotropic T-cell infiltrate consistent with the diagnosis of MF. The T-cell clonality study was positive. The patient was started on narrowband ultraviolet B (NBUVB) phototherapy and topical steroids. He had a 50% reduction in his patches after 10 months of treatment, after which he developed a single annular plaque on his left thigh. The biopsy specimen demonstrated large cells that were diffusely CD8[+] and CD30[-] . Clobetasol propionate ointment was prescribed, which led to complete resolution of the plaque within 2 weeks. NBUVB phototherapy was continued and the patient had a complete response within the following 5 months. The case is an example of exceptionally rare large-cell transformation in pediatric MF and stresses the importance of regular follow-up of these patients. SN - 1525-1470 UR - https://www.unboundmedicine.com/medline/citation/28804923/Hypopigmented_Mycosis_Fungoides_with_Large_Cell_Transformation_in_a_Child_ DB - PRIME DP - Unbound Medicine ER -