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Differences between somatostatin-28 and somatostatin-14 with respect to their biological effects in healthy humans and acromegalics.
Clin Physiol Biochem. 1986; 4(6):372-83.CP

Abstract

In order to compare the effects of somatostatin-28 (SS-28) with those of somatostatin-14 (SS-14) in humans, we administered both compounds randomly in 5 healthy persons and 3 patients with active acromegaly. Blood glucose, growth hormone, insulin, glucagon, TSH, FSH, LH and prolactin were estimated after arginine, TRH and LHRH stimulation in the normals and without stimulation in the acromegalics. Both substances were administered in doses of 25, 50, 200 and 250 micrograms. Our results indicate that SS-28 is at least 5 times more potent in man than SS-14 as far as inhibition of growth hormone, insulin, glucagon and prolactin secretion is concerned. On the other hand SS-28 is at least 2 times more potent than SS-14 in the inhibition of TSH, FSH and LH. If this difference in potency is calculated on the basis of equimolarity, the action of SS-28 becomes even much greater. According to these findings, SS-28 appears to be either the main hormone and SS-14 a fragment of it with a lesser degree of biologic activity, or the prohormone with special properties.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2880690

Citation

Hadjidakis, D J., et al. "Differences Between Somatostatin-28 and Somatostatin-14 With Respect to Their Biological Effects in Healthy Humans and Acromegalics." Clinical Physiology and Biochemistry, vol. 4, no. 6, 1986, pp. 372-83.
Hadjidakis DJ, Raptis SA, Souvatzoglou A, et al. Differences between somatostatin-28 and somatostatin-14 with respect to their biological effects in healthy humans and acromegalics. Clin Physiol Biochem. 1986;4(6):372-83.
Hadjidakis, D. J., Raptis, S. A., Souvatzoglou, A., Karaiskos, C., Diamantopoulos, E. J., & Moulopoulos, S. D. (1986). Differences between somatostatin-28 and somatostatin-14 with respect to their biological effects in healthy humans and acromegalics. Clinical Physiology and Biochemistry, 4(6), 372-83.
Hadjidakis DJ, et al. Differences Between Somatostatin-28 and Somatostatin-14 With Respect to Their Biological Effects in Healthy Humans and Acromegalics. Clin Physiol Biochem. 1986;4(6):372-83. PubMed PMID: 2880690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences between somatostatin-28 and somatostatin-14 with respect to their biological effects in healthy humans and acromegalics. AU - Hadjidakis,D J, AU - Raptis,S A, AU - Souvatzoglou,A, AU - Karaiskos,C, AU - Diamantopoulos,E J, AU - Moulopoulos,S D, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 372 EP - 83 JF - Clinical physiology and biochemistry JO - Clin Physiol Biochem VL - 4 IS - 6 N2 - In order to compare the effects of somatostatin-28 (SS-28) with those of somatostatin-14 (SS-14) in humans, we administered both compounds randomly in 5 healthy persons and 3 patients with active acromegaly. Blood glucose, growth hormone, insulin, glucagon, TSH, FSH, LH and prolactin were estimated after arginine, TRH and LHRH stimulation in the normals and without stimulation in the acromegalics. Both substances were administered in doses of 25, 50, 200 and 250 micrograms. Our results indicate that SS-28 is at least 5 times more potent in man than SS-14 as far as inhibition of growth hormone, insulin, glucagon and prolactin secretion is concerned. On the other hand SS-28 is at least 2 times more potent than SS-14 in the inhibition of TSH, FSH and LH. If this difference in potency is calculated on the basis of equimolarity, the action of SS-28 becomes even much greater. According to these findings, SS-28 appears to be either the main hormone and SS-14 a fragment of it with a lesser degree of biologic activity, or the prohormone with special properties. SN - 0252-1164 UR - https://www.unboundmedicine.com/medline/citation/2880690/Differences_between_somatostatin_28_and_somatostatin_14_with_respect_to_their_biological_effects_in_healthy_humans_and_acromegalics_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:2880690 DB - PRIME DP - Unbound Medicine ER -