TY - JOUR T1 - Medical treatment of acromegaly with SMS 201-995, a somatostatin analog: a comparison with bromocriptine. AU - Chiodini,P G, AU - Cozzi,R, AU - Dallabonzana,D, AU - Oppizzi,G, AU - Verde,G, AU - Petroncini,M, AU - Liuzzi,A, AU - del Pozo,E, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 447 EP - 53 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 64 IS - 3 N2 - We studied the effects of acute and chronic sc administration of SMS 201-995 (SMS), a long-acting somatostatin analog, in acromegalic patients. The results were compared with those obtained in the same patients treated with oral bromocriptine (Brc). A single dose of 50 micrograms SMS administered to 28 patients induced a more rapid, greater, and more prolonged reduction in plasma GH levels than did 2.5 mg Brc. Chronic treatment [60-330 days; mean 208 +/- 23 (+/- SEM)] with SMS (100-300 micrograms/day) induced in 16 patients a significantly greater decrease in mean plasma GH and somatomedin-C levels than did 20 mg Brc. Combined treatment with the 2 agents had an additional effect. The clinical and metabolic parameters of acromegaly dramatically improved in all patients whose plasma GH and somatomedin-C levels decreased even if they were not normalized by SMS. Reduction in tumor size occurred in 3 of the 10 patients examined by computed tomography before and during SMS treatment. We conclude that SMS is more effective than Brc and that the 2 drugs may be complementary in the medical treatment of acromegaly. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2880861/Medical_treatment_of_acromegaly_with_SMS_201_995_a_somatostatin_analog:_a_comparison_with_bromocriptine_ DB - PRIME DP - Unbound Medicine ER -