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[Severe Yellow fever vaccine-associated disease: a case report and current overview].
Dtsch Med Wochenschr. 2017 Aug; 142(16):1219-1222.DM

Abstract

History and physical examination A 56-year-old man developed high fever with severe headaches, fatigue, impaired concentration skills, and an exanthema 5 days after a yellow fever (YF) vaccination. Laboratory tests Liver enzymes and YF antibody titers were remarkably elevated. YF vaccine virus was detected in urine by PCR. Diagnosis and therapy Initially, severe YF vaccine-associated visceral disease was suspected and treated symptomatically. Clinical Course His fever ceased after 10 days in total, no organ failure developed. However, postencephalitic symptoms persisted with fatigue and impaired concentration, memory, and reading skills and partly incapability to work for over 3 months. A diagnosis was made of suspected YF vaccine-associated neurotropic disease. Conclusion Severe vaccine-derived adverse effects need to be considered in the indication process for YF vaccination.

Authors+Show Affiliations

Tropenklinik Paul-Lechler-Krankenhaus, Tübingen.Bernhard-Nocht-Institut, Hamburg.Robert Koch Institut, Berlin.Tropenklinik Paul-Lechler-Krankenhaus, Tübingen.

Pub Type(s)

Case Reports
Journal Article

Language

ger

PubMed ID

28810279

Citation

Slesak, Günther, et al. "[Severe Yellow Fever Vaccine-associated Disease: a Case Report and Current Overview]." Deutsche Medizinische Wochenschrift (1946), vol. 142, no. 16, 2017, pp. 1219-1222.
Slesak G, Gabriel M, Domingo C, et al. [Severe Yellow fever vaccine-associated disease: a case report and current overview]. Dtsch Med Wochenschr. 2017;142(16):1219-1222.
Slesak, G., Gabriel, M., Domingo, C., & Schäfer, J. (2017). [Severe Yellow fever vaccine-associated disease: a case report and current overview]. Deutsche Medizinische Wochenschrift (1946), 142(16), 1219-1222. https://doi.org/10.1055/s-0043-114729
Slesak G, et al. [Severe Yellow Fever Vaccine-associated Disease: a Case Report and Current Overview]. Dtsch Med Wochenschr. 2017;142(16):1219-1222. PubMed PMID: 28810279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Severe Yellow fever vaccine-associated disease: a case report and current overview]. AU - Slesak,Günther, AU - Gabriel,Martin, AU - Domingo,Cristina, AU - Schäfer,Johannes, Y1 - 2017/08/15/ PY - 2017/8/16/entrez PY - 2017/8/16/pubmed PY - 2017/8/26/medline SP - 1219 EP - 1222 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 142 IS - 16 N2 - History and physical examination A 56-year-old man developed high fever with severe headaches, fatigue, impaired concentration skills, and an exanthema 5 days after a yellow fever (YF) vaccination. Laboratory tests Liver enzymes and YF antibody titers were remarkably elevated. YF vaccine virus was detected in urine by PCR. Diagnosis and therapy Initially, severe YF vaccine-associated visceral disease was suspected and treated symptomatically. Clinical Course His fever ceased after 10 days in total, no organ failure developed. However, postencephalitic symptoms persisted with fatigue and impaired concentration, memory, and reading skills and partly incapability to work for over 3 months. A diagnosis was made of suspected YF vaccine-associated neurotropic disease. Conclusion Severe vaccine-derived adverse effects need to be considered in the indication process for YF vaccination. SN - 1439-4413 UR - https://www.unboundmedicine.com/medline/citation/28810279/[Severe_Yellow_fever_vaccine_associated_disease:_a_case_report_and_current_overview]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0043-114729 DB - PRIME DP - Unbound Medicine ER -