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Prolactinoma in a Dog.
Vet Pathol. 2017 11; 54(6):972-976.VP

Abstract

A 12-year-old male Yorkshire Terrier was presented because of decreased appetite. Physical examination revealed mammary gland swelling and galactorrhea. Contrast-enhanced computed tomographic scanning of the skull indicated an enlarged pituitary gland, compatible with a pituitary tumor. The serum prolactin concentration was markedly elevated. One week after the start of treatment with the dopamine agonist cabergoline, the serum prolactin concentration normalized and the galactorrhea resolved. Cabergoline was administered for approximately 4 months and then discontinued. Subsequently, serum prolactin concentration increased again, and mammary gland swelling and galactorrhea reappeared. The dog was euthanized 10 months after the first detection of the galactorrhea because of problems not directly related to pituitary disease. Postmortem examination revealed an infiltrative adenoma of the pituitary gland with immunolabeling for prolactin. The clinical and histopathologic findings indicated the diagnosis of a functional prolactinoma in a male dog.

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Authors+Show Affiliations

Cosio C
1 Veterinary Clinic Croce di Gussago, Brescia, Italy. Contributed equally to this work.
Sartori E
2 Veterinary Clinic Dr Luccardini Lorenzo, Pavia, Italy. Contributed equally to this work.
Garatti M
3 Veterinary Clinic S. Antonio, Salò, Italy.
Luccardini L
2 Veterinary Clinic Dr Luccardini Lorenzo, Pavia, Italy.
Grinwis GCM
4 Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Kooistra HS
5 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Fracassi F
6 Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

MeSH

AdenomaAnimalsCabergolineDogsDopamine AgonistsErgolinesFatal OutcomeMalePituitary NeoplasmsProlactinProlactinomaTomography Scanners, X-Ray Computed

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28812531

Citation

Cosio, Cristina, et al. "Prolactinoma in a Dog." Veterinary Pathology, vol. 54, no. 6, 2017, pp. 972-976.
Cosio C, Sartori E, Garatti M, et al. Prolactinoma in a Dog. Vet Pathol. 2017;54(6):972-976.
Cosio, C., Sartori, E., Garatti, M., Luccardini, L., Grinwis, G. C. M., Kooistra, H. S., & Fracassi, F. (2017). Prolactinoma in a Dog. Veterinary Pathology, 54(6), 972-976. https://doi.org/10.1177/0300985817726118
Cosio C, et al. Prolactinoma in a Dog. Vet Pathol. 2017;54(6):972-976. PubMed PMID: 28812531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolactinoma in a Dog. AU - Cosio,Cristina, AU - Sartori,Elena, AU - Garatti,Marcello, AU - Luccardini,Lorenzo, AU - Grinwis,G C M, AU - Kooistra,Hans S, AU - Fracassi,Federico, Y1 - 2017/08/16/ PY - 2017/8/16/pubmed PY - 2018/5/4/medline PY - 2017/8/17/entrez KW - cabergoline KW - dogs KW - endocrine diseases KW - galactorrhea KW - gynecomastia KW - neoplasia KW - paraneoplastic syndrome KW - prolactin KW - prolactinoma SP - 972 EP - 976 JF - Veterinary pathology JO - Vet Pathol VL - 54 IS - 6 N2 - A 12-year-old male Yorkshire Terrier was presented because of decreased appetite. Physical examination revealed mammary gland swelling and galactorrhea. Contrast-enhanced computed tomographic scanning of the skull indicated an enlarged pituitary gland, compatible with a pituitary tumor. The serum prolactin concentration was markedly elevated. One week after the start of treatment with the dopamine agonist cabergoline, the serum prolactin concentration normalized and the galactorrhea resolved. Cabergoline was administered for approximately 4 months and then discontinued. Subsequently, serum prolactin concentration increased again, and mammary gland swelling and galactorrhea reappeared. The dog was euthanized 10 months after the first detection of the galactorrhea because of problems not directly related to pituitary disease. Postmortem examination revealed an infiltrative adenoma of the pituitary gland with immunolabeling for prolactin. The clinical and histopathologic findings indicated the diagnosis of a functional prolactinoma in a male dog. SN - 1544-2217 UR - https://www.unboundmedicine.com/medline/citation/28812531/Prolactinoma_in_a_Dog_ L2 - https://journals.sagepub.com/doi/10.1177/0300985817726118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -