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Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infants.
Am J Clin Nutr. 2017 Oct; 106(4):1020-1031.AJ

Abstract

Background:

Whether consumption of prebiotics increases iron absorption in infants is unclear.

Objective:

We set out to determine whether prebiotic consumption affects iron absorption from a micronutrient powder (MNP) containing a mixture of ferrous fumarate and sodium iron EDTA (FeFum+NaFeEDTA) in Kenyan infants.

Design:

Infants (n = 50; aged 6-14 mo) consumed maize porridge that was fortified with an MNP containing FeFum+NaFeEDTA and 7.5 g galacto-oligosaccharides (GOSs) (Fe+GOS group, n = 22) or the same MNP without GOSs (Fe group, n = 28) each day for 3 wk. Then, on 2 consecutive days, we fed all infants isotopically labeled maize porridge and MNP test meals containing 5 mg Fe as 57FeFum+Na58FeEDTA or ferrous sulfate (54FeSO4). Iron absorption was measured as the erythrocyte incorporation of stable isotopes. Iron markers, fecal pH, and bacterial groups were assessed at baseline and 3 wk. Comparisons within and between groups were done with the use of mixed-effects models.

Results:

There was a significant group-by-compound interaction on iron absorption (P = 0.011). The median percentages of fractional iron absorption from FeFum+NaFeEDTA and from FeSO4 in the Fe group were 11.6% (IQR: 6.9-19.9%) and 20.3% (IQR: 14.2-25.7%), respectively, (P < 0.001) and, in the Fe+GOS group, were 18.8% (IQR: 8.3-37.5%) and 25.5% (IQR: 15.1-37.8%), respectively (P = 0.124). Between groups, iron absorption was greater from the FeFum+NaFeEDTA (P = 0.047) in the Fe+GOS group but not from the FeSO4 (P = 0.653). The relative iron bioavailability from FeFum+NaFeEDTA compared with FeSO4 was higher in the Fe+GOS group than in the Fe group (88% compared with 63%; P = 0.006). There was a significant time-by-group interaction on Bifidobacterium spp. (P = 0.008) and Lactobacillus/Pediococcus/Leuconostoc spp. (P = 0.018); Lactobacillus/Pediococcus/Leuconostoc spp. decreased in the Fe group (P = 0.013), and there was a nonsignificant trend toward higher Bifidobacterium spp. in the Fe+GOS group (P = 0.099). At 3 wk, iron absorption was negatively correlated with fecal pH (P < 0.001) and positively correlated with Lactobacillus/Pediococcus/Leuconostoc spp. (P = 0.001).

Conclusion:

GOS consumption by infants increased iron absorption by 62% from an MNP containing FeFum+NaFeEDTA, thereby possibly reflecting greater colonic iron absorption. This trial was registered at clinicaltrials.gov as NCT02666417.

Authors+Show Affiliations

Laboratories of Human Nutrition and.College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.Laboratories of Human Nutrition and.Laboratories of Human Nutrition and.Department of Pediatrics, Msambweni County Referral Hospital, Msambweni, Kenya; and.Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.Laboratories of Human Nutrition and.Technical University of Mombasa, Mombasa, Kenya.Laboratories of Human Nutrition and.Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.Laboratories of Human Nutrition and michael.zimmermann@hest.ethz.ch.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28814396

Citation

Paganini, Daniela, et al. "Consumption of Galacto-oligosaccharides Increases Iron Absorption From a Micronutrient Powder Containing Ferrous Fumarate and Sodium Iron EDTA: a Stable-isotope Study in Kenyan Infants." The American Journal of Clinical Nutrition, vol. 106, no. 4, 2017, pp. 1020-1031.
Paganini D, Uyoga MA, Cercamondi CI, et al. Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infants. Am J Clin Nutr. 2017;106(4):1020-1031.
Paganini, D., Uyoga, M. A., Cercamondi, C. I., Moretti, D., Mwasi, E., Schwab, C., Bechtler, S., Mutuku, F. M., Galetti, V., Lacroix, C., Karanja, S., & Zimmermann, M. B. (2017). Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infants. The American Journal of Clinical Nutrition, 106(4), 1020-1031. https://doi.org/10.3945/ajcn.116.145060
Paganini D, et al. Consumption of Galacto-oligosaccharides Increases Iron Absorption From a Micronutrient Powder Containing Ferrous Fumarate and Sodium Iron EDTA: a Stable-isotope Study in Kenyan Infants. Am J Clin Nutr. 2017;106(4):1020-1031. PubMed PMID: 28814396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infants. AU - Paganini,Daniela, AU - Uyoga,Mary A, AU - Cercamondi,Colin I, AU - Moretti,Diego, AU - Mwasi,Edith, AU - Schwab,Clarissa, AU - Bechtler,Salome, AU - Mutuku,Francis M, AU - Galetti,Valeria, AU - Lacroix,Christophe, AU - Karanja,Simon, AU - Zimmermann,Michael B, Y1 - 2017/08/16/ PY - 2016/09/08/received PY - 2017/07/06/accepted PY - 2017/8/18/pubmed PY - 2017/10/14/medline PY - 2017/8/18/entrez KW - GOS KW - Kenya KW - anemia KW - galacto-oligosaccharides KW - infants KW - iron absorption KW - iron deficiency KW - micronutrient powder KW - prebiotics KW - stable isotopes SP - 1020 EP - 1031 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 106 IS - 4 N2 - Background: Whether consumption of prebiotics increases iron absorption in infants is unclear.Objective: We set out to determine whether prebiotic consumption affects iron absorption from a micronutrient powder (MNP) containing a mixture of ferrous fumarate and sodium iron EDTA (FeFum+NaFeEDTA) in Kenyan infants.Design: Infants (n = 50; aged 6-14 mo) consumed maize porridge that was fortified with an MNP containing FeFum+NaFeEDTA and 7.5 g galacto-oligosaccharides (GOSs) (Fe+GOS group, n = 22) or the same MNP without GOSs (Fe group, n = 28) each day for 3 wk. Then, on 2 consecutive days, we fed all infants isotopically labeled maize porridge and MNP test meals containing 5 mg Fe as 57FeFum+Na58FeEDTA or ferrous sulfate (54FeSO4). Iron absorption was measured as the erythrocyte incorporation of stable isotopes. Iron markers, fecal pH, and bacterial groups were assessed at baseline and 3 wk. Comparisons within and between groups were done with the use of mixed-effects models.Results: There was a significant group-by-compound interaction on iron absorption (P = 0.011). The median percentages of fractional iron absorption from FeFum+NaFeEDTA and from FeSO4 in the Fe group were 11.6% (IQR: 6.9-19.9%) and 20.3% (IQR: 14.2-25.7%), respectively, (P < 0.001) and, in the Fe+GOS group, were 18.8% (IQR: 8.3-37.5%) and 25.5% (IQR: 15.1-37.8%), respectively (P = 0.124). Between groups, iron absorption was greater from the FeFum+NaFeEDTA (P = 0.047) in the Fe+GOS group but not from the FeSO4 (P = 0.653). The relative iron bioavailability from FeFum+NaFeEDTA compared with FeSO4 was higher in the Fe+GOS group than in the Fe group (88% compared with 63%; P = 0.006). There was a significant time-by-group interaction on Bifidobacterium spp. (P = 0.008) and Lactobacillus/Pediococcus/Leuconostoc spp. (P = 0.018); Lactobacillus/Pediococcus/Leuconostoc spp. decreased in the Fe group (P = 0.013), and there was a nonsignificant trend toward higher Bifidobacterium spp. in the Fe+GOS group (P = 0.099). At 3 wk, iron absorption was negatively correlated with fecal pH (P < 0.001) and positively correlated with Lactobacillus/Pediococcus/Leuconostoc spp. (P = 0.001).Conclusion: GOS consumption by infants increased iron absorption by 62% from an MNP containing FeFum+NaFeEDTA, thereby possibly reflecting greater colonic iron absorption. This trial was registered at clinicaltrials.gov as NCT02666417. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28814396/Consumption_of_galacto_oligosaccharides_increases_iron_absorption_from_a_micronutrient_powder_containing_ferrous_fumarate_and_sodium_iron_EDTA:_a_stable_isotope_study_in_Kenyan_infants_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.116.145060 DB - PRIME DP - Unbound Medicine ER -