Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment.
Addict Health. 2016 Fall; 8(4):211-217.AH

Abstract

BACKGROUND

Iran is one of the major consumers of opium and opiate substances in the world. Addiction has become a very important issue in the 21st century and an urgent one in Iran. The consumption of this substance leaves a variety of impacts on the human body. The goal of this study is to investigate the changes of the biochemical parameters derived from opiate substances in addicts during their treatment.

METHODS

This is a cross-sectional research that focused on 40 individuals dependent on the consumption of opium. Their blood samples were taken before and during treatment, and their fasting blood sugar (FBS), sodium, calcium, phosphorus, creatinine, urea, uric acid, total protein, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol were measured. Data were analyzed by SPSS using paired t-test.

FINDINGS

The results showed that serum uric acid, LDL, cholesterol, and the total protein levels significantly decreased during the treatment in comparison with the time before the treatment (P < 0.050). Yet, the serum fasting glucose, urea, creatinine, HDL, triglycerides, calcium, phosphorous, sodium, and potassium showed no significant change the time prior and during the treatment.

CONCLUSION

Given the findings of the analysis, opium addiction has a number of destructive impacts on the lipid profile and uric acid. In addition, the level of total protein decreased during the treatment.

Links

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Authors+Show Affiliations

Barzehkar S

Resident, Neurosciences Research Center AND Department of Internal Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Gozashti MH

Associate Professor, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Divsalar K

Researcher, Neurosciences Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Mashrouteh M

General Practitioner, Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Darvishi-Lardi AH

Student of Medicine, Infectious Disease and Tropical Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28819551

Citation

Barzehkar, Sedigheh, et al. "Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment." Addiction & Health, vol. 8, no. 4, 2016, pp. 211-217.

Barzehkar S, Gozashti MH, Divsalar K, et al. Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment. Addict Health. 2016;8(4):211-217.

Barzehkar, S., Gozashti, M. H., Divsalar, K., Mashrouteh, M., & Darvishi-Lardi, A. H. (2016). Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment. Addiction & Health, 8(4), 211-217.

Barzehkar S, et al. Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment. Addict Health. 2016;8(4):211-217. PubMed PMID: 28819551.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment. AU - Barzehkar,Sedigheh, AU - Gozashti,Mohammad Hossein, AU - Divsalar,Kouros, AU - Mashrouteh,Mahdieh, AU - Darvishi-Lardi,Amir Hossein, PY - 2017/8/19/entrez PY - 2017/8/19/pubmed PY - 2017/8/19/medline KW - Addiction treatment KW - Blood biochemical parameters KW - Dependence on opium KW - Opium SP - 211 EP - 217 JF - Addiction & health JO - Addict Health VL - 8 IS - 4 N2 - BACKGROUND: Iran is one of the major consumers of opium and opiate substances in the world. Addiction has become a very important issue in the 21st century and an urgent one in Iran. The consumption of this substance leaves a variety of impacts on the human body. The goal of this study is to investigate the changes of the biochemical parameters derived from opiate substances in addicts during their treatment. METHODS: This is a cross-sectional research that focused on 40 individuals dependent on the consumption of opium. Their blood samples were taken before and during treatment, and their fasting blood sugar (FBS), sodium, calcium, phosphorus, creatinine, urea, uric acid, total protein, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol were measured. Data were analyzed by SPSS using paired t-test. FINDINGS: The results showed that serum uric acid, LDL, cholesterol, and the total protein levels significantly decreased during the treatment in comparison with the time before the treatment (P < 0.050). Yet, the serum fasting glucose, urea, creatinine, HDL, triglycerides, calcium, phosphorous, sodium, and potassium showed no significant change the time prior and during the treatment. CONCLUSION: Given the findings of the analysis, opium addiction has a number of destructive impacts on the lipid profile and uric acid. In addition, the level of total protein decreased during the treatment. SN - 2008-4633 UR - https://www.unboundmedicine.com/medline/citation/28819551/Investigating_Changes_in_Serum_Biochemical_Parameters_in_Opium_Addicts_Before_and_During_Addiction_Treatment_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28819551/ DB - PRIME DP - Unbound Medicine ER -

Tags

Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment.Addict Health. 2016 Fall; 8(4):211-217.AH