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Contribution of inherited thrombophilia to recurrent miscarriage in the Polish population.
Ginekol Pol. 2017; 88(7):385-392.GP

Abstract

INTRODUCTION

The aim of the study was to evaluate the contribution of genetic variants determining inherited thrombophilia to recurrent miscarriage (RM) in the Polish population. The following polymorphisms were analyzed: 1691G>A, 1328T>C of coagulation factor V, 20210G>A of coagulation factor II, R353Q (11496G>A) of coagulation factor VII, 667C>T, 1298A>C, 1793G>A of MTHFR.

MATERIAL AND METHODS

A total of 359 women with ≥ 2 subsequent recurrent miscarriages (303 < 13 weeks of gestation (w.g.) and 56 between 13-22 w.g.) and 400 healthy controls were included in the study. Frequency of the genetic polymor-phisms was determined with the PCR/RFLP method.

RESULTS

Higher frequency of the 20210GA genotype was found in the RM < 13 w.g. (2.97 vs. 1.50% in controls, OR = 2.01, ns) and the RM 13-22 w.g. (5.36 vs. 1.50% in controls, OR = 3.72, p = 0.09) subgroups. Statistically significantly higher frequency of the 11496GA genotype was noted in controls as compared to the RM 13-22 w.g. subgroup (10.71 vs. 23.00% in controls, OR = 0.40, p = 0.02). Statistically significantly higher frequency of the 1793GA genotype was observed in the RM < 13 w.g. subgroup as compared to controls (12.21 vs. 7.75% in controls, OR = 1.66, p = 0.03). No significant correlations were found as far as the rest of the analyzed polymorphisms are concerned.

CONCLUSIONS

The obtained results suggest that the 1793G>A MTHFR, R353Q (11496G>A) factor VII gene and the 20210G>A factor II gene polymorphisms play a role in the etiology of RM in the Polish population.

Authors+Show Affiliations

No affiliation info availableDivision of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland; Laboratory of Molecular Biology, Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland. magda.barlik@op.pl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28819944

Citation

Wolski, Hubert, et al. "Contribution of Inherited Thrombophilia to Recurrent Miscarriage in the Polish Population." Ginekologia Polska, vol. 88, no. 7, 2017, pp. 385-392.
Wolski H, Barlik M, Drews K, et al. Contribution of inherited thrombophilia to recurrent miscarriage in the Polish population. Ginekol Pol. 2017;88(7):385-392.
Wolski, H., Barlik, M., Drews, K., Klejewski, A., Kurzawińska, G., Ożarowski, M., Łowicki, Z., & Seremak-Mrozikiewicz, A. (2017). Contribution of inherited thrombophilia to recurrent miscarriage in the Polish population. Ginekologia Polska, 88(7), 385-392. https://doi.org/10.5603/GP.a2017.0072
Wolski H, et al. Contribution of Inherited Thrombophilia to Recurrent Miscarriage in the Polish Population. Ginekol Pol. 2017;88(7):385-392. PubMed PMID: 28819944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of inherited thrombophilia to recurrent miscarriage in the Polish population. AU - Wolski,Hubert, AU - Barlik,Magdalena, AU - Drews,Krzysztof, AU - Klejewski,Andrzej, AU - Kurzawińska,Grażyna, AU - Ożarowski,Marcin, AU - Łowicki,Zdzisław, AU - Seremak-Mrozikiewicz,Agnieszka, PY - 2017/06/02/received PY - 2017/07/06/accepted PY - 2017/8/19/entrez PY - 2017/8/19/pubmed PY - 2018/7/18/medline KW - genetic polymorphism KW - inherited thrombophilia KW - recurrent miscarriage SP - 385 EP - 392 JF - Ginekologia polska JO - Ginekol Pol VL - 88 IS - 7 N2 - INTRODUCTION: The aim of the study was to evaluate the contribution of genetic variants determining inherited thrombophilia to recurrent miscarriage (RM) in the Polish population. The following polymorphisms were analyzed: 1691G>A, 1328T>C of coagulation factor V, 20210G>A of coagulation factor II, R353Q (11496G>A) of coagulation factor VII, 667C>T, 1298A>C, 1793G>A of MTHFR. MATERIAL AND METHODS: A total of 359 women with ≥ 2 subsequent recurrent miscarriages (303 < 13 weeks of gestation (w.g.) and 56 between 13-22 w.g.) and 400 healthy controls were included in the study. Frequency of the genetic polymor-phisms was determined with the PCR/RFLP method. RESULTS: Higher frequency of the 20210GA genotype was found in the RM < 13 w.g. (2.97 vs. 1.50% in controls, OR = 2.01, ns) and the RM 13-22 w.g. (5.36 vs. 1.50% in controls, OR = 3.72, p = 0.09) subgroups. Statistically significantly higher frequency of the 11496GA genotype was noted in controls as compared to the RM 13-22 w.g. subgroup (10.71 vs. 23.00% in controls, OR = 0.40, p = 0.02). Statistically significantly higher frequency of the 1793GA genotype was observed in the RM < 13 w.g. subgroup as compared to controls (12.21 vs. 7.75% in controls, OR = 1.66, p = 0.03). No significant correlations were found as far as the rest of the analyzed polymorphisms are concerned. CONCLUSIONS: The obtained results suggest that the 1793G>A MTHFR, R353Q (11496G>A) factor VII gene and the 20210G>A factor II gene polymorphisms play a role in the etiology of RM in the Polish population. SN - 0017-0011 UR - https://www.unboundmedicine.com/medline/citation/28819944/Contribution_of_inherited_thrombophilia_to_recurrent_miscarriage_in_the_Polish_population_ L2 - https://journals.viamedica.pl/ginekologia_polska/article/view/53972 DB - PRIME DP - Unbound Medicine ER -