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Postinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis.
J Child Neurol. 2017 Oct; 32(12):996-999.JC

Abstract

We report the case of a 9-year-old girl admitted with fever, headache, and a cerebrospinal fluid lymphocytic pleocytosis. Polymerase chain reaction was positive for human herpes virus 6. She subsequently developed ataxia and bilateral loss of vision. Magnetic resonance imaging (MRI) showed bilateral optic nerve lesions with extension to optic chiasm and a short-segment myelitis. Serologic studies were positive for Borrelia burgdorferi IgM. Anti-aquaporin 4 antibody was negative and anti-myelin oligodendrocyte glycoprotein antibody (MOG) positive. After intravenous methylprednisolone, ceftriaxone, and intravenous immunoglobulin, her vision slowly recovered. The patient was discharged with only mild visual acuity loss, 1 month after admission. Brain MRI was repeated later and was normal and MOG assay became negative. In our view, this patient suffered from a postinfectious, anti-MOG-mediated, spinal cord and optic nerve demyelination.

Authors+Show Affiliations

1 Neurology Department, Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.2 Neurology Department, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.3 Infectious Diseases Unit, Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28820014

Citation

Vieira, J P., et al. "Postinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis." Journal of Child Neurology, vol. 32, no. 12, 2017, pp. 996-999.
Vieira JP, Sequeira J, Brito MJ. Postinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis. J Child Neurol. 2017;32(12):996-999.
Vieira, J. P., Sequeira, J., & Brito, M. J. (2017). Postinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis. Journal of Child Neurology, 32(12), 996-999. https://doi.org/10.1177/0883073817724927
Vieira JP, Sequeira J, Brito MJ. Postinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis. J Child Neurol. 2017;32(12):996-999. PubMed PMID: 28820014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis. AU - Vieira,J P, AU - Sequeira,J, AU - Brito,M J, Y1 - 2017/08/18/ PY - 2017/8/19/pubmed PY - 2018/5/15/medline PY - 2017/8/19/entrez KW - Lyme borreliosis KW - bilateral optic neuritis KW - myelin-oligodendrocyte glycoprotein antibodies KW - neuromyelitis optica spectrum disorders SP - 996 EP - 999 JF - Journal of child neurology JO - J Child Neurol VL - 32 IS - 12 N2 - We report the case of a 9-year-old girl admitted with fever, headache, and a cerebrospinal fluid lymphocytic pleocytosis. Polymerase chain reaction was positive for human herpes virus 6. She subsequently developed ataxia and bilateral loss of vision. Magnetic resonance imaging (MRI) showed bilateral optic nerve lesions with extension to optic chiasm and a short-segment myelitis. Serologic studies were positive for Borrelia burgdorferi IgM. Anti-aquaporin 4 antibody was negative and anti-myelin oligodendrocyte glycoprotein antibody (MOG) positive. After intravenous methylprednisolone, ceftriaxone, and intravenous immunoglobulin, her vision slowly recovered. The patient was discharged with only mild visual acuity loss, 1 month after admission. Brain MRI was repeated later and was normal and MOG assay became negative. In our view, this patient suffered from a postinfectious, anti-MOG-mediated, spinal cord and optic nerve demyelination. SN - 1708-8283 UR - https://www.unboundmedicine.com/medline/citation/28820014/Postinfectious_Anti_Myelin_Oligodendrocyte_Glycoprotein_Antibody_Positive_Optic_Neuritis_and_Myelitis_ L2 - https://journals.sagepub.com/doi/10.1177/0883073817724927?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -