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Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016.
Am J Trop Med Hyg. 2017 Nov; 97(5):1313-1315.AJ

Abstract

Seasonal outbreaks of acute encephalitis syndrome (AES) with high mortality occur every year in Gorakhpur region of Uttar Pradesh, India. Earlier studies indicated the role of scrub typhus as the important etiology of AES in the region. AES cases were hospitalized late in the course of their illness. We established surveillance for acute febrile illness (AFI) (fever ≥ 4 days duration) in peripheral health facilities in Gorakhpur district to understand the relative contribution of scrub typhus. Of the 224 patients enrolled during the 3-month period corresponding to the peak of AES cases in the region, about one-fifth had immunoglobulin M (IgM) antibodies against Orientia tsutsugamushi. Dengue and leptospira accounted for 8% and 3% of febrile illness cases. Treating patients with AFI attending the peripheral health facilities with doxycycline could prevent development of AES and thereby reduce deaths due to AES in Gorakhpur region.

Authors+Show Affiliations

National Institute of Epidemiology, Chennai, India.Department of Pediatrics, BRD Medical College, Gorakhpur, India.Pediatric Infectious Diseases, Christian Medical College, Vellore, India.National Institute of Epidemiology, Chennai, India.Pediatric Infectious Diseases, Christian Medical College, Vellore, India.National Institute of Epidemiology, Chennai, India.National Institute of Virology, Gorakhpur Unit, Gorakhpur, India.Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, Delhi, India.National Institute of Epidemiology, Chennai, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28820712

Citation

Vivian Thangaraj, Jeromie Wesley, et al. "Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016." The American Journal of Tropical Medicine and Hygiene, vol. 97, no. 5, 2017, pp. 1313-1315.
Vivian Thangaraj JW, Mittal M, Verghese VP, et al. Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016. Am J Trop Med Hyg. 2017;97(5):1313-1315.
Vivian Thangaraj, J. W., Mittal, M., Verghese, V. P., Kumar, C. P. G., Rose, W., Sabarinathan, R., Pandey, A. K., Gupta, N., & Murhekar, M. (2017). Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016. The American Journal of Tropical Medicine and Hygiene, 97(5), 1313-1315. https://doi.org/10.4269/ajtmh.17-0135
Vivian Thangaraj JW, et al. Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016. Am J Trop Med Hyg. 2017;97(5):1313-1315. PubMed PMID: 28820712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016. AU - Vivian Thangaraj,Jeromie Wesley, AU - Mittal,Mahima, AU - Verghese,Valsan Philip, AU - Kumar,C P Girish, AU - Rose,Winsley, AU - Sabarinathan,R, AU - Pandey,Ashok Kumar, AU - Gupta,Nivedita, AU - Murhekar,Manoj, Y1 - 2017/08/18/ PY - 2017/8/19/pubmed PY - 2017/12/1/medline PY - 2017/8/19/entrez SP - 1313 EP - 1315 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 97 IS - 5 N2 - Seasonal outbreaks of acute encephalitis syndrome (AES) with high mortality occur every year in Gorakhpur region of Uttar Pradesh, India. Earlier studies indicated the role of scrub typhus as the important etiology of AES in the region. AES cases were hospitalized late in the course of their illness. We established surveillance for acute febrile illness (AFI) (fever ≥ 4 days duration) in peripheral health facilities in Gorakhpur district to understand the relative contribution of scrub typhus. Of the 224 patients enrolled during the 3-month period corresponding to the peak of AES cases in the region, about one-fifth had immunoglobulin M (IgM) antibodies against Orientia tsutsugamushi. Dengue and leptospira accounted for 8% and 3% of febrile illness cases. Treating patients with AFI attending the peripheral health facilities with doxycycline could prevent development of AES and thereby reduce deaths due to AES in Gorakhpur region. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/28820712/Scrub_Typhus_as_an_Etiology_of_Acute_Febrile_Illness_in_Gorakhpur_Uttar_Pradesh_India_2016_ L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0135?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -