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Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome.
Plast Reconstr Surg. 2017 Dec; 140(6):1240-1249.PR

Abstract

BACKGROUND

The aim of this study was to identify cephalometric measurements associated with clinical severity in patients with Treacher Collins syndrome.

METHODS

A retrospective single-institution review of patients with Treacher Collins syndrome was conducted. Preoperative cephalograms and computed tomographic scans (n = 30) were evaluated. Fifty cephalometric measurements were compared to age-specific normative data using analysis of variance. These cephalometric measurements and the patient's Pruzansky classification were correlated to clinical severity using Spearman analysis. Clinical severity was defined as severe (required tracheostomy), moderate (obstructive sleep apnea, oral cleft, or gastrostomy-tube), or mild (absence of listed comorbidities). Cephalometric measurements with a strong correlation (r > 0.60) were identified as predictors of clinical severity.

RESULTS

Cephalograms of the study population contained 30 measurements that were found to be significantly different from normative data (p < 0.01). These measurements were related largely to maxillary/mandibular projection, maxillary/mandibular plane angle, mandibular morphology, facial height, facial convexity, and mandible/throat position. Ten of these 30 statistically significant measurements in addition to Pruzansky classification were found to be strongly correlated (r > 0.60) to clinical severity. These measurements include the following: mandibular projection/position (sella-nasion-pogonion, r = -0.64; hyoid-menton, r = -0.62); posterior facial height (posterior facial height/anterior facial height, r = 0.60; condyle-gonion, r = -0.66); maxillary/mandibular plane angle (sella-nasion-mandibular plane, r = 0.62; Frankfort horizontal-mandibular plane, r = 0.61; sella-nasion-palatal plane, r = 0.69; sella-nasion-symphysis, r = -0.69); and Pruzansky classification (r = 0.82).

CONCLUSION

Specific cephalometric measurements of increased mandibular retrognathia, decreased posterior facial height, more obtuse maxillary/mandibular plane angle and more obtuse symphysis notch angle are strongly correlated to increased clinical severity in patients with Treacher Collins syndrome.

Authors+Show Affiliations

New York, N.Y.; Isparta and Antalya, Turkey. From the Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center; the Department of Orthodontics, Süeyman Demirel University Faculty of Dentistry; and Department of Orthodontics, Akdeniz University Faculty of Dentistry.New York, N.Y.; Isparta and Antalya, Turkey. From the Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center; the Department of Orthodontics, Süeyman Demirel University Faculty of Dentistry; and Department of Orthodontics, Akdeniz University Faculty of Dentistry.New York, N.Y.; Isparta and Antalya, Turkey. From the Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center; the Department of Orthodontics, Süeyman Demirel University Faculty of Dentistry; and Department of Orthodontics, Akdeniz University Faculty of Dentistry.New York, N.Y.; Isparta and Antalya, Turkey. From the Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center; the Department of Orthodontics, Süeyman Demirel University Faculty of Dentistry; and Department of Orthodontics, Akdeniz University Faculty of Dentistry.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28820843

Citation

Esenlik, Elçin, et al. "Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome." Plastic and Reconstructive Surgery, vol. 140, no. 6, 2017, pp. 1240-1249.
Esenlik E, Plana NM, Grayson BH, et al. Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome. Plast Reconstr Surg. 2017;140(6):1240-1249.
Esenlik, E., Plana, N. M., Grayson, B. H., & Flores, R. L. (2017). Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome. Plastic and Reconstructive Surgery, 140(6), 1240-1249. https://doi.org/10.1097/PRS.0000000000003853
Esenlik E, et al. Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome. Plast Reconstr Surg. 2017;140(6):1240-1249. PubMed PMID: 28820843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome. AU - Esenlik,Elçin, AU - Plana,Natalie M, AU - Grayson,Barry H, AU - Flores,Roberto L, PY - 2017/8/19/pubmed PY - 2017/12/5/medline PY - 2017/8/19/entrez SP - 1240 EP - 1249 JF - Plastic and reconstructive surgery JO - Plast Reconstr Surg VL - 140 IS - 6 N2 - BACKGROUND: The aim of this study was to identify cephalometric measurements associated with clinical severity in patients with Treacher Collins syndrome. METHODS: A retrospective single-institution review of patients with Treacher Collins syndrome was conducted. Preoperative cephalograms and computed tomographic scans (n = 30) were evaluated. Fifty cephalometric measurements were compared to age-specific normative data using analysis of variance. These cephalometric measurements and the patient's Pruzansky classification were correlated to clinical severity using Spearman analysis. Clinical severity was defined as severe (required tracheostomy), moderate (obstructive sleep apnea, oral cleft, or gastrostomy-tube), or mild (absence of listed comorbidities). Cephalometric measurements with a strong correlation (r > 0.60) were identified as predictors of clinical severity. RESULTS: Cephalograms of the study population contained 30 measurements that were found to be significantly different from normative data (p < 0.01). These measurements were related largely to maxillary/mandibular projection, maxillary/mandibular plane angle, mandibular morphology, facial height, facial convexity, and mandible/throat position. Ten of these 30 statistically significant measurements in addition to Pruzansky classification were found to be strongly correlated (r > 0.60) to clinical severity. These measurements include the following: mandibular projection/position (sella-nasion-pogonion, r = -0.64; hyoid-menton, r = -0.62); posterior facial height (posterior facial height/anterior facial height, r = 0.60; condyle-gonion, r = -0.66); maxillary/mandibular plane angle (sella-nasion-mandibular plane, r = 0.62; Frankfort horizontal-mandibular plane, r = 0.61; sella-nasion-palatal plane, r = 0.69; sella-nasion-symphysis, r = -0.69); and Pruzansky classification (r = 0.82). CONCLUSION: Specific cephalometric measurements of increased mandibular retrognathia, decreased posterior facial height, more obtuse maxillary/mandibular plane angle and more obtuse symphysis notch angle are strongly correlated to increased clinical severity in patients with Treacher Collins syndrome. SN - 1529-4242 UR - https://www.unboundmedicine.com/medline/citation/28820843/Cephalometric_Predictors_of_Clinical_Severity_in_Treacher_Collins_Syndrome_ L2 - https://Insights.ovid.com/pubmed?pmid=28820843 DB - PRIME DP - Unbound Medicine ER -