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[Pharmacokinetic research strategies of compatibilities and synergistic effects of classical Danshen herb pairs based on pharmacokinetics of "Danshen-Bingpian" and "Danshen-Honghua"].
Zhongguo Zhong Yao Za Zhi 2017; 42(12):2413-2419ZZ

Abstract

Herb pairs are usual clinical compatibility forms and one of compound prescription sources in Chinese medicine. Pharmacokinetic research in vivo is one of the important items in elucidating the mechanism for synergistic and attenuated mechanisms of herb pairs. The paper comprehensively summarized and systemized the pharmacokinetic researches of marker-ingredients about Danshen-Honghua and Danshen-Bingpian in order to elucidate the rationality and scientificity of herb pairs and provide some feasible suggestions on the pharmacokinetics of drugs in the future. In view of complicated system of Traditional Chinese medicines and a chemical system that is not separated from its natural state, comparative pharmacokinetic researches on marker-ingredients from the herb pairs are reasonable to elucidate the synergistic and attenuated mechanisms of monarch-subjects compatible herbs and monarch-guide compatible herbs. Such pharmacokinetic research can better explain the mechanism of drug compatibility, while the pharmacokinetic researches based on the monomer chemical compositions and marker-ingredients that have been separated from complex chemical environment of traditional Chinese Medicine are still unreasonable and should be discussed deeply.

Authors+Show Affiliations

Guang'anmen Hospital, China Academy of Chinese Medicinal Sciences, Beijing 100053, China.Guang'anmen Hospital, China Academy of Chinese Medicinal Sciences, Beijing 100053, China.

Pub Type(s)

Journal Article
Review

Language

chi

PubMed ID

28822201

Citation

Zhang, Cui-Ying, and Wei-Guang Ren. "[Pharmacokinetic Research Strategies of Compatibilities and Synergistic Effects of Classical Danshen Herb Pairs Based On Pharmacokinetics of "Danshen-Bingpian" and "Danshen-Honghua"]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 42, no. 12, 2017, pp. 2413-2419.
Zhang CY, Ren WG. [Pharmacokinetic research strategies of compatibilities and synergistic effects of classical Danshen herb pairs based on pharmacokinetics of "Danshen-Bingpian" and "Danshen-Honghua"]. Zhongguo Zhong Yao Za Zhi. 2017;42(12):2413-2419.
Zhang, C. Y., & Ren, W. G. (2017). [Pharmacokinetic research strategies of compatibilities and synergistic effects of classical Danshen herb pairs based on pharmacokinetics of "Danshen-Bingpian" and "Danshen-Honghua"]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(12), pp. 2413-2419. doi:10.19540/j.cnki.cjcmm.20170307.005.
Zhang CY, Ren WG. [Pharmacokinetic Research Strategies of Compatibilities and Synergistic Effects of Classical Danshen Herb Pairs Based On Pharmacokinetics of "Danshen-Bingpian" and "Danshen-Honghua"]. Zhongguo Zhong Yao Za Zhi. 2017;42(12):2413-2419. PubMed PMID: 28822201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pharmacokinetic research strategies of compatibilities and synergistic effects of classical Danshen herb pairs based on pharmacokinetics of "Danshen-Bingpian" and "Danshen-Honghua"]. AU - Zhang,Cui-Ying, AU - Ren,Wei-Guang, PY - 2017/02/17/received PY - 2017/8/20/entrez PY - 2017/8/20/pubmed PY - 2018/6/30/medline KW - Danshen-Bingpian herb pair KW - Danshen-Honghua herb pair KW - compatibilities of herb pairs KW - pharmacokinetics SP - 2413 EP - 2419 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 42 IS - 12 N2 - Herb pairs are usual clinical compatibility forms and one of compound prescription sources in Chinese medicine. Pharmacokinetic research in vivo is one of the important items in elucidating the mechanism for synergistic and attenuated mechanisms of herb pairs. The paper comprehensively summarized and systemized the pharmacokinetic researches of marker-ingredients about Danshen-Honghua and Danshen-Bingpian in order to elucidate the rationality and scientificity of herb pairs and provide some feasible suggestions on the pharmacokinetics of drugs in the future. In view of complicated system of Traditional Chinese medicines and a chemical system that is not separated from its natural state, comparative pharmacokinetic researches on marker-ingredients from the herb pairs are reasonable to elucidate the synergistic and attenuated mechanisms of monarch-subjects compatible herbs and monarch-guide compatible herbs. Such pharmacokinetic research can better explain the mechanism of drug compatibility, while the pharmacokinetic researches based on the monomer chemical compositions and marker-ingredients that have been separated from complex chemical environment of traditional Chinese Medicine are still unreasonable and should be discussed deeply. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/28822201/[Pharmacokinetic_research_strategies_of_compatibilities_and_synergistic_effects_of_classical_Danshen_herb_pairs_based_on_pharmacokinetics_of_"Danshen_Bingpian"_and_"Danshen_Honghua"]_ DB - PRIME DP - Unbound Medicine ER -