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Predictors of longer-term outcome in the Vienna omega-3 high-risk study.
Schizophr Res. 2018 03; 193:168-172.SR

Abstract

Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results. This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo. Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12weeks and follow-up assessment after a median of 6.7years. Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor. Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: nilufar.mossaheb@meduniwien.ac.at.Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: miriam.schaefer@orygen.org.au.Department of Child and Adolescent Psychiatry, Medical University Vienna, Waehringer Guertel 18-10, 1090 Vienna, Austria. Electronic address: monika.schloegelhofer@meduniwien.ac.at.Department of Child and Adolescent Medicine, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: claudia.klier@meduniwien.ac.at.Department of Psychiatry, University Hospital Jena, Philosophenweg 3, D-07743 Jena, Germany. Electronic address: Stefan.Smesny@med.uni-jena.de.Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: pat.mcgorry@orygen.org.au.Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, 1 James Cook Drive, Townsville, QLD 4810, Australia. Electronic address: maximus.berger@jcu.edu.au.Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: amminger@unimelb.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28823721

Citation

Mossaheb, Nilufar, et al. "Predictors of Longer-term Outcome in the Vienna Omega-3 High-risk Study." Schizophrenia Research, vol. 193, 2018, pp. 168-172.
Mossaheb N, Schäfer MR, Schlögelhofer M, et al. Predictors of longer-term outcome in the Vienna omega-3 high-risk study. Schizophr Res. 2018;193:168-172.
Mossaheb, N., Schäfer, M. R., Schlögelhofer, M., Klier, C. M., Smesny, S., McGorry, P. D., Berger, M., & Amminger, G. P. (2018). Predictors of longer-term outcome in the Vienna omega-3 high-risk study. Schizophrenia Research, 193, 168-172. https://doi.org/10.1016/j.schres.2017.08.010
Mossaheb N, et al. Predictors of Longer-term Outcome in the Vienna Omega-3 High-risk Study. Schizophr Res. 2018;193:168-172. PubMed PMID: 28823721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of longer-term outcome in the Vienna omega-3 high-risk study. AU - Mossaheb,Nilufar, AU - Schäfer,Miriam R, AU - Schlögelhofer,Monika, AU - Klier,Claudia M, AU - Smesny,Stefan, AU - McGorry,Patrick D, AU - Berger,Maximus, AU - Amminger,G Paul, Y1 - 2017/08/18/ PY - 2016/12/11/received PY - 2017/07/24/revised PY - 2017/08/08/accepted PY - 2017/8/22/pubmed PY - 2018/11/14/medline PY - 2017/8/22/entrez KW - Fish oil KW - Outcome KW - Polyunsaturated fatty acids KW - Prodrome KW - Psychosis KW - Ultra-high risk SP - 168 EP - 172 JF - Schizophrenia research JO - Schizophr Res VL - 193 N2 - Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results. This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo. Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12weeks and follow-up assessment after a median of 6.7years. Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor. Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/28823721/Predictors_of_longer_term_outcome_in_the_Vienna_omega_3_high_risk_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(17)30484-X DB - PRIME DP - Unbound Medicine ER -