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A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis.
Acta Med Okayama. 2017 Aug; 71(4):357-362.AM

Abstract

Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography(ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitrate might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitrate for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet. The primary endpoint is the occurrence of PEP. This study will clarify whether NSAIDs plus nitrate can prevent PEP.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Corrected and Republished Article

Language

eng

PubMed ID

28824193

Citation

Tomoda, Takeshi, et al. "A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis." Acta Medica Okayama, vol. 71, no. 4, 2017, pp. 357-362.
Tomoda T, Kato H, Mizukawa S, et al. A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis. Acta Med Okayama. 2017;71(4):357-362.
Tomoda, T., Kato, H., Mizukawa, S., Muro, S., Akimoto, Y., Uchida, D., Matsumoto, K., Yamamoto, N., Horiguchi, S., Tsutsumi, K., & Okada, H. (2017). A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis. Acta Medica Okayama, 71(4), 357-362. https://doi.org/10.18926/AMO/55314
Tomoda T, et al. A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis. Acta Med Okayama. 2017;71(4):357-362. PubMed PMID: 28824193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis. AU - Tomoda,Takeshi, AU - Kato,Hironari, AU - Mizukawa,Sho, AU - Muro,Shinichiro, AU - Akimoto,Yutaka, AU - Uchida,Daisuke, AU - Matsumoto,Kazuyuki, AU - Yamamoto,Naoki, AU - Horiguchi,Shigeru, AU - Tsutsumi,Koichiro, AU - Okada,Hiroyuki, PY - 2017/8/22/entrez PY - 2017/8/22/pubmed PY - 2017/8/22/medline KW - NSAIDs KW - nitrate KW - post-ERCP pancreatitis SP - 357 EP - 362 JF - Acta medica Okayama JO - Acta Med. Okayama VL - 71 IS - 4 N2 - Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography(ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitrate might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitrate for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet. The primary endpoint is the occurrence of PEP. This study will clarify whether NSAIDs plus nitrate can prevent PEP. SN - 0386-300X UR - https://www.unboundmedicine.com/medline/citation/28824193/A_Multicenter_Prospective_Randomized_Controlled_Trial_Evaluating_the_Efficacy_of_Rectal_Diclofenac_and_Sublingual_Nitrate_as_a_Combined_Prophylactic_Treatment_for_Post_ERCP_Pancreatitis_ L2 - https://doi.org/10.18926/AMO/55314 DB - PRIME DP - Unbound Medicine ER -
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